GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1

GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1

The transcription factor GFI1 mediates the DNA damage response (DDR) of T cells through a yet unknown mechanism. Here the authors show that GFI1 can adopt non-transcriptional roles during DDR, enabling PRMT1 to bind and methylate the DNA repair proteins MRE11 and 53BP1.

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Auteurs principaux: Charles Vadnais, Riyan Chen, Jennifer Fraszczak, Zhenbao Yu, Jonathan Boulais, Jordan Pinder, Daria Frank, Cyrus Khandanpour, Josée Hébert, Graham Dellaire, Jean-François Côté, Stéphane Richard, Alexandre Orthwein, Elliot Drobetsky, Tarik Möröy
Format: article
Langue:EN
Publié: Nature Portfolio 2018
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Q
Accès en ligne:https://doaj.org/article/84219a0ff4704d3586e8769eac7e762a
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spelling oai:doaj.org-article:84219a0ff4704d3586e8769eac7e762a2021-12-02T17:33:00ZGFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP110.1038/s41467-018-03817-52041-1723https://doaj.org/article/84219a0ff4704d3586e8769eac7e762a2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03817-5https://doaj.org/toc/2041-1723The transcription factor GFI1 mediates the DNA damage response (DDR) of T cells through a yet unknown mechanism. Here the authors show that GFI1 can adopt non-transcriptional roles during DDR, enabling PRMT1 to bind and methylate the DNA repair proteins MRE11 and 53BP1.Charles VadnaisRiyan ChenJennifer FraszczakZhenbao YuJonathan BoulaisJordan PinderDaria FrankCyrus KhandanpourJosée HébertGraham DellaireJean-François CôtéStéphane RichardAlexandre OrthweinElliot DrobetskyTarik MöröyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Charles Vadnais
Riyan Chen
Jennifer Fraszczak
Zhenbao Yu
Jonathan Boulais
Jordan Pinder
Daria Frank
Cyrus Khandanpour
Josée Hébert
Graham Dellaire
Jean-François Côté
Stéphane Richard
Alexandre Orthwein
Elliot Drobetsky
Tarik Möröy
GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1
description The transcription factor GFI1 mediates the DNA damage response (DDR) of T cells through a yet unknown mechanism. Here the authors show that GFI1 can adopt non-transcriptional roles during DDR, enabling PRMT1 to bind and methylate the DNA repair proteins MRE11 and 53BP1.
format article
author Charles Vadnais
Riyan Chen
Jennifer Fraszczak
Zhenbao Yu
Jonathan Boulais
Jordan Pinder
Daria Frank
Cyrus Khandanpour
Josée Hébert
Graham Dellaire
Jean-François Côté
Stéphane Richard
Alexandre Orthwein
Elliot Drobetsky
Tarik Möröy
author_facet Charles Vadnais
Riyan Chen
Jennifer Fraszczak
Zhenbao Yu
Jonathan Boulais
Jordan Pinder
Daria Frank
Cyrus Khandanpour
Josée Hébert
Graham Dellaire
Jean-François Côté
Stéphane Richard
Alexandre Orthwein
Elliot Drobetsky
Tarik Möröy
author_sort Charles Vadnais
title GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1
title_short GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1
title_full GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1
title_fullStr GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1
title_full_unstemmed GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1
title_sort gfi1 facilitates efficient dna repair by regulating prmt1 dependent methylation of mre11 and 53bp1
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/84219a0ff4704d3586e8769eac7e762a
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