An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution

An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution

Type 3 innate lymphoid cells (ILC3) are involved in maintaining gut immune homeostasis. Here the authors identify a circular RNA, circKcnt2, to be induced in ILC3s from inflamed gut, yet circKcnt2 deletion aggravates mouse experimental colitis, thereby implicating circKcnt2 as a potential feedback r...

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Autores principales: Benyu Liu, Buqing Ye, Xiaoxiao Zhu, Liuliu Yang, Huimu Li, Nian Liu, Pingping Zhu, Tiankun Lu, Luyun He, Yong Tian, Zusen Fan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/8425200ce38d4d1dafc5142daa12241b
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spelling oai:doaj.org-article:8425200ce38d4d1dafc5142daa12241b2021-12-02T15:08:41ZAn inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution10.1038/s41467-020-17944-52041-1723https://doaj.org/article/8425200ce38d4d1dafc5142daa12241b2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17944-5https://doaj.org/toc/2041-1723Type 3 innate lymphoid cells (ILC3) are involved in maintaining gut immune homeostasis. Here the authors identify a circular RNA, circKcnt2, to be induced in ILC3s from inflamed gut, yet circKcnt2 deletion aggravates mouse experimental colitis, thereby implicating circKcnt2 as a potential feedback regulator of ILC3 activation and gut immunity.Benyu LiuBuqing YeXiaoxiao ZhuLiuliu YangHuimu LiNian LiuPingping ZhuTiankun LuLuyun HeYong TianZusen FanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Benyu Liu
Buqing Ye
Xiaoxiao Zhu
Liuliu Yang
Huimu Li
Nian Liu
Pingping Zhu
Tiankun Lu
Luyun He
Yong Tian
Zusen Fan
An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution
description Type 3 innate lymphoid cells (ILC3) are involved in maintaining gut immune homeostasis. Here the authors identify a circular RNA, circKcnt2, to be induced in ILC3s from inflamed gut, yet circKcnt2 deletion aggravates mouse experimental colitis, thereby implicating circKcnt2 as a potential feedback regulator of ILC3 activation and gut immunity.
format article
author Benyu Liu
Buqing Ye
Xiaoxiao Zhu
Liuliu Yang
Huimu Li
Nian Liu
Pingping Zhu
Tiankun Lu
Luyun He
Yong Tian
Zusen Fan
author_facet Benyu Liu
Buqing Ye
Xiaoxiao Zhu
Liuliu Yang
Huimu Li
Nian Liu
Pingping Zhu
Tiankun Lu
Luyun He
Yong Tian
Zusen Fan
author_sort Benyu Liu
title An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution
title_short An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution
title_full An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution
title_fullStr An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution
title_full_unstemmed An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution
title_sort inducible circular rna circkcnt2 inhibits ilc3 activation to facilitate colitis resolution
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/8425200ce38d4d1dafc5142daa12241b
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