Kisameet Clay Exhibits Potent Antibacterial Activity against the ESKAPE Pathogens

ABSTRACT The ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) pathogens cause an increasing number of nosocomial infections worldwide since they escape the inhibitory effect of the available antibio...

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Autores principales:	Shekooh Behroozian, Sarah L. Svensson, Julian Davies
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2016
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/8426b1102db341eca1207e4c38cd346d
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spelling	oai:doaj.org-article:8426b1102db341eca1207e4c38cd346d2021-11-15T15:49:40ZKisameet Clay Exhibits Potent Antibacterial Activity against the ESKAPE Pathogens10.1128/mBio.01842-152150-7511https://doaj.org/article/8426b1102db341eca1207e4c38cd346d2016-03-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01842-15https://doaj.org/toc/2150-7511ABSTRACT The ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) pathogens cause an increasing number of nosocomial infections worldwide since they escape the inhibitory effect of the available antibiotics and the immune response. Here, we report the broad-spectrum and potent antibacterial activity of Kisameet clay, a natural clay mineral from British Columbia, Canada, against a group of multidrug-resistant ESKAPE strains. The results suggest that this natural clay might be developed as a therapeutic option for the treatment of serious infections caused by these important pathogens. IMPORTANCE More than 50 years of misuse and overuse of antibiotics has led to a plague of antibiotic resistance that threatens to reduce the efficacy of antimicrobial agents available for the treatment of infections due to resistant organisms. The main threat is nosocomial infections in which certain pathogens, notably the ESKAPE organisms, are essentially untreatable and contribute to increasing mortality and morbidity in surgical wards. The pipeline of novel antimicrobials in the pharmaceutical industry is essentially empty. Thus, there is a great need to seek for new sources for the treatment of recalcitrant infectious diseases. We describe experiments that demonstrate the efficacy of a “natural” medicine, Kisameet clay, against all of the ESKAPE strains. We suggest that this material is worthy of clinical investigation for the treatment of infections due to multidrug-resistant organisms.Shekooh BehroozianSarah L. SvenssonJulian DaviesAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 1 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Shekooh Behroozian Sarah L. Svensson Julian Davies Kisameet Clay Exhibits Potent Antibacterial Activity against the ESKAPE Pathogens
description	ABSTRACT The ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) pathogens cause an increasing number of nosocomial infections worldwide since they escape the inhibitory effect of the available antibiotics and the immune response. Here, we report the broad-spectrum and potent antibacterial activity of Kisameet clay, a natural clay mineral from British Columbia, Canada, against a group of multidrug-resistant ESKAPE strains. The results suggest that this natural clay might be developed as a therapeutic option for the treatment of serious infections caused by these important pathogens. IMPORTANCE More than 50 years of misuse and overuse of antibiotics has led to a plague of antibiotic resistance that threatens to reduce the efficacy of antimicrobial agents available for the treatment of infections due to resistant organisms. The main threat is nosocomial infections in which certain pathogens, notably the ESKAPE organisms, are essentially untreatable and contribute to increasing mortality and morbidity in surgical wards. The pipeline of novel antimicrobials in the pharmaceutical industry is essentially empty. Thus, there is a great need to seek for new sources for the treatment of recalcitrant infectious diseases. We describe experiments that demonstrate the efficacy of a “natural” medicine, Kisameet clay, against all of the ESKAPE strains. We suggest that this material is worthy of clinical investigation for the treatment of infections due to multidrug-resistant organisms.
format	article
author	Shekooh Behroozian Sarah L. Svensson Julian Davies
author_facet	Shekooh Behroozian Sarah L. Svensson Julian Davies
author_sort	Shekooh Behroozian
title	Kisameet Clay Exhibits Potent Antibacterial Activity against the ESKAPE Pathogens
title_short	Kisameet Clay Exhibits Potent Antibacterial Activity against the ESKAPE Pathogens
title_full	Kisameet Clay Exhibits Potent Antibacterial Activity against the ESKAPE Pathogens
title_fullStr	Kisameet Clay Exhibits Potent Antibacterial Activity against the ESKAPE Pathogens
title_full_unstemmed	Kisameet Clay Exhibits Potent Antibacterial Activity against the ESKAPE Pathogens
title_sort	kisameet clay exhibits potent antibacterial activity against the eskape pathogens
publisher	American Society for Microbiology
publishDate	2016
url	https://doaj.org/article/8426b1102db341eca1207e4c38cd346d
work_keys_str_mv	AT shekoohbehroozian kisameetclayexhibitspotentantibacterialactivityagainsttheeskapepathogens AT sarahlsvensson kisameetclayexhibitspotentantibacterialactivityagainsttheeskapepathogens AT juliandavies kisameetclayexhibitspotentantibacterialactivityagainsttheeskapepathogens
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Kisameet Clay Exhibits Potent Antibacterial Activity against the ESKAPE Pathogens

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