The chemical defensome of five model teleost fish

Abstract How an organism copes with chemicals is largely determined by the genes and proteins that collectively function to defend against, detoxify and eliminate chemical stressors. This integrative network includes receptors and transcription factors, biotransformation enzymes, transporters, antio...

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Autores principales:	Marta Eide, Xiaokang Zhang, Odd André Karlsen, Jared V. Goldstone, John Stegeman, Inge Jonassen, Anders Goksøyr
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8427bd82a1dc4576a2ec6d9270890131
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spelling	oai:doaj.org-article:8427bd82a1dc4576a2ec6d92708901312021-12-02T15:45:15ZThe chemical defensome of five model teleost fish10.1038/s41598-021-89948-02045-2322https://doaj.org/article/8427bd82a1dc4576a2ec6d92708901312021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89948-0https://doaj.org/toc/2045-2322Abstract How an organism copes with chemicals is largely determined by the genes and proteins that collectively function to defend against, detoxify and eliminate chemical stressors. This integrative network includes receptors and transcription factors, biotransformation enzymes, transporters, antioxidants, and metal- and heat-responsive genes, and is collectively known as the chemical defensome. Teleost fish is the largest group of vertebrate species and can provide valuable insights into the evolution and functional diversity of defensome genes. We have previously shown that the xenosensing pregnane x receptor (pxr, nr1i2) is lost in many teleost species, including Atlantic cod (Gadus morhua) and three-spined stickleback (Gasterosteus aculeatus), but it is not known if compensatory mechanisms or signaling pathways have evolved in its absence. In this study, we compared the genes comprising the chemical defensome of five fish species that span the teleosteii evolutionary branch often used as model species in toxicological studies and environmental monitoring programs: zebrafish (Danio rerio), medaka (Oryzias latipes), Atlantic killifish (Fundulus heteroclitus), Atlantic cod, and three-spined stickleback. Genome mining revealed evolved differences in the number and composition of defensome genes that can have implication for how these species sense and respond to environmental pollutants, but we did not observe any candidates of compensatory mechanisms or pathways in cod and stickleback in the absence of pxr. The results indicate that knowledge regarding the diversity and function of the defensome will be important for toxicological testing and risk assessment studies.Marta EideXiaokang ZhangOdd André KarlsenJared V. GoldstoneJohn StegemanInge JonassenAnders GoksøyrNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marta Eide Xiaokang Zhang Odd André Karlsen Jared V. Goldstone John Stegeman Inge Jonassen Anders Goksøyr The chemical defensome of five model teleost fish
description	Abstract How an organism copes with chemicals is largely determined by the genes and proteins that collectively function to defend against, detoxify and eliminate chemical stressors. This integrative network includes receptors and transcription factors, biotransformation enzymes, transporters, antioxidants, and metal- and heat-responsive genes, and is collectively known as the chemical defensome. Teleost fish is the largest group of vertebrate species and can provide valuable insights into the evolution and functional diversity of defensome genes. We have previously shown that the xenosensing pregnane x receptor (pxr, nr1i2) is lost in many teleost species, including Atlantic cod (Gadus morhua) and three-spined stickleback (Gasterosteus aculeatus), but it is not known if compensatory mechanisms or signaling pathways have evolved in its absence. In this study, we compared the genes comprising the chemical defensome of five fish species that span the teleosteii evolutionary branch often used as model species in toxicological studies and environmental monitoring programs: zebrafish (Danio rerio), medaka (Oryzias latipes), Atlantic killifish (Fundulus heteroclitus), Atlantic cod, and three-spined stickleback. Genome mining revealed evolved differences in the number and composition of defensome genes that can have implication for how these species sense and respond to environmental pollutants, but we did not observe any candidates of compensatory mechanisms or pathways in cod and stickleback in the absence of pxr. The results indicate that knowledge regarding the diversity and function of the defensome will be important for toxicological testing and risk assessment studies.
format	article
author	Marta Eide Xiaokang Zhang Odd André Karlsen Jared V. Goldstone John Stegeman Inge Jonassen Anders Goksøyr
author_facet	Marta Eide Xiaokang Zhang Odd André Karlsen Jared V. Goldstone John Stegeman Inge Jonassen Anders Goksøyr
author_sort	Marta Eide
title	The chemical defensome of five model teleost fish
title_short	The chemical defensome of five model teleost fish
title_full	The chemical defensome of five model teleost fish
title_fullStr	The chemical defensome of five model teleost fish
title_full_unstemmed	The chemical defensome of five model teleost fish
title_sort	chemical defensome of five model teleost fish
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8427bd82a1dc4576a2ec6d9270890131
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The chemical defensome of five model teleost fish

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