Coagulation factors II,V and methylene tetrahydrofolate reductase gene polymorphism in patients with diabetic nephropathy: prevalence, clinical and prognostic implications

Aim. To study prevalence, clinical and prognostic significance of prothrombotic genotypes pre-dominant in inborn thrombophilia in patients with diabeticnephropathy (DN). Materials and methods. A total of 90 patients with DN were examined; 54 and 36 cases suffered DM1 and DM2 respectively. Control...

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Autores principales:	Olga Filippovna Sibireva, Ekaterina Yur'evna Khitrinskaya, Vadim Vital'evich Kalyuzhin, Aleksey Eduardovich Sazonov, Igor Ivanovich Ivanchuk, Viktoriya Yur'evna Grankina
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2010
Materias:	diabetes mellitus diabetic nephropathy gene polymorphism methylenetetrahydrofolate reductase Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/8427ed650fb04f0f88539d0be18eb4dd
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spelling	oai:doaj.org-article:8427ed650fb04f0f88539d0be18eb4dd2021-11-14T09:00:14ZCoagulation factors II,V and methylene tetrahydrofolate reductase gene polymorphism in patients with diabetic nephropathy: prevalence, clinical and prognostic implications2072-03512072-037810.14341/2072-0351-6009https://doaj.org/article/8427ed650fb04f0f88539d0be18eb4dd2010-03-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6009https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To study prevalence, clinical and prognostic significance of prothrombotic genotypes pre-dominant in inborn thrombophilia in patients with diabeticnephropathy (DN). Materials and methods. A total of 90 patients with DN were examined; 54 and 36 cases suffered DM1 and DM2 respectively. Control group comprised100 healthy subjects. PCR was used to iden-tify single nucleotide substitution (C677T) in the methylene tetrahydrofolate reductase gene (MTHFR),point mutation in coagulation factor V gene (FV), and G202210A mutation in factor II gene (FII). Results. The probability of DN in patients with DM1 increases in the presence of Leiden mutation and in DM2 patients in the presence of single nucleotidesubstitu-tion (C677T) in MTHFR gene and G202210A mutation in the 3-untranslated region of FII. Conclusion. The prevalence of the above mutations associated with blood coagulation potential in DN patients is higher than in healthy subjects.Key words: diabetes mellitus, diabetic nephropathy, gene polymorphism, methylenetetrahydrofolate reductaseOlga Filippovna SibirevaEkaterina Yur'evna KhitrinskayaVadim Vital'evich KalyuzhinAleksey Eduardovich SazonovIgor Ivanovich IvanchukViktoriya Yur'evna GrankinaEndocrinology Research Centrearticlediabetes mellitusdiabetic nephropathygene polymorphismmethylenetetrahydrofolate reductaseNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 13, Iss 1, Pp 6-9 (2010)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus diabetic nephropathy gene polymorphism methylenetetrahydrofolate reductase Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus diabetic nephropathy gene polymorphism methylenetetrahydrofolate reductase Nutritional diseases. Deficiency diseases RC620-627 Olga Filippovna Sibireva Ekaterina Yur'evna Khitrinskaya Vadim Vital'evich Kalyuzhin Aleksey Eduardovich Sazonov Igor Ivanovich Ivanchuk Viktoriya Yur'evna Grankina Coagulation factors II,V and methylene tetrahydrofolate reductase gene polymorphism in patients with diabetic nephropathy: prevalence, clinical and prognostic implications
description	Aim. To study prevalence, clinical and prognostic significance of prothrombotic genotypes pre-dominant in inborn thrombophilia in patients with diabeticnephropathy (DN). Materials and methods. A total of 90 patients with DN were examined; 54 and 36 cases suffered DM1 and DM2 respectively. Control group comprised100 healthy subjects. PCR was used to iden-tify single nucleotide substitution (C677T) in the methylene tetrahydrofolate reductase gene (MTHFR),point mutation in coagulation factor V gene (FV), and G202210A mutation in factor II gene (FII). Results. The probability of DN in patients with DM1 increases in the presence of Leiden mutation and in DM2 patients in the presence of single nucleotidesubstitu-tion (C677T) in MTHFR gene and G202210A mutation in the 3-untranslated region of FII. Conclusion. The prevalence of the above mutations associated with blood coagulation potential in DN patients is higher than in healthy subjects.Key words: diabetes mellitus, diabetic nephropathy, gene polymorphism, methylenetetrahydrofolate reductase
format	article
author	Olga Filippovna Sibireva Ekaterina Yur'evna Khitrinskaya Vadim Vital'evich Kalyuzhin Aleksey Eduardovich Sazonov Igor Ivanovich Ivanchuk Viktoriya Yur'evna Grankina
author_facet	Olga Filippovna Sibireva Ekaterina Yur'evna Khitrinskaya Vadim Vital'evich Kalyuzhin Aleksey Eduardovich Sazonov Igor Ivanovich Ivanchuk Viktoriya Yur'evna Grankina
author_sort	Olga Filippovna Sibireva
title	Coagulation factors II,V and methylene tetrahydrofolate reductase gene polymorphism in patients with diabetic nephropathy: prevalence, clinical and prognostic implications
title_short	Coagulation factors II,V and methylene tetrahydrofolate reductase gene polymorphism in patients with diabetic nephropathy: prevalence, clinical and prognostic implications
title_full	Coagulation factors II,V and methylene tetrahydrofolate reductase gene polymorphism in patients with diabetic nephropathy: prevalence, clinical and prognostic implications
title_fullStr	Coagulation factors II,V and methylene tetrahydrofolate reductase gene polymorphism in patients with diabetic nephropathy: prevalence, clinical and prognostic implications
title_full_unstemmed	Coagulation factors II,V and methylene tetrahydrofolate reductase gene polymorphism in patients with diabetic nephropathy: prevalence, clinical and prognostic implications
title_sort	coagulation factors ii,v and methylene tetrahydrofolate reductase gene polymorphism in patients with diabetic nephropathy: prevalence, clinical and prognostic implications
publisher	Endocrinology Research Centre
publishDate	2010
url	https://doaj.org/article/8427ed650fb04f0f88539d0be18eb4dd
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Coagulation factors II,V and methylene tetrahydrofolate reductase gene polymorphism in patients with diabetic nephropathy: prevalence, clinical and prognostic implications

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