Chloroplastic metabolic engineering coupled with isoprenoid pool enhancement for committed taxanes biosynthesis in Nicotiana benthamiana

Engineering Taxol pathway in microbes needs to overcome the difficulty of expressing plant P450 enzymes. Here, the authors use a compartmentalized metabolic engineering strategy to construct the taxanes production pathway in chloroplasts of Nicotiana benthamiana and realize the production of taxadie...

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Autores principales:	Jianhua Li, Ishmael Mutanda, Kaibo Wang, Lei Yang, Jiawei Wang, Yong Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8428c9211e514f2db08b62a0cc8920f5
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spelling	oai:doaj.org-article:8428c9211e514f2db08b62a0cc8920f52021-12-02T17:01:25ZChloroplastic metabolic engineering coupled with isoprenoid pool enhancement for committed taxanes biosynthesis in Nicotiana benthamiana10.1038/s41467-019-12879-y2041-1723https://doaj.org/article/8428c9211e514f2db08b62a0cc8920f52019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12879-yhttps://doaj.org/toc/2041-1723Engineering Taxol pathway in microbes needs to overcome the difficulty of expressing plant P450 enzymes. Here, the authors use a compartmentalized metabolic engineering strategy to construct the taxanes production pathway in chloroplasts of Nicotiana benthamiana and realize the production of taxadience-5α-ol.Jianhua LiIshmael MutandaKaibo WangLei YangJiawei WangYong WangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jianhua Li Ishmael Mutanda Kaibo Wang Lei Yang Jiawei Wang Yong Wang Chloroplastic metabolic engineering coupled with isoprenoid pool enhancement for committed taxanes biosynthesis in Nicotiana benthamiana
description	Engineering Taxol pathway in microbes needs to overcome the difficulty of expressing plant P450 enzymes. Here, the authors use a compartmentalized metabolic engineering strategy to construct the taxanes production pathway in chloroplasts of Nicotiana benthamiana and realize the production of taxadience-5α-ol.
format	article
author	Jianhua Li Ishmael Mutanda Kaibo Wang Lei Yang Jiawei Wang Yong Wang
author_facet	Jianhua Li Ishmael Mutanda Kaibo Wang Lei Yang Jiawei Wang Yong Wang
author_sort	Jianhua Li
title	Chloroplastic metabolic engineering coupled with isoprenoid pool enhancement for committed taxanes biosynthesis in Nicotiana benthamiana
title_short	Chloroplastic metabolic engineering coupled with isoprenoid pool enhancement for committed taxanes biosynthesis in Nicotiana benthamiana
title_full	Chloroplastic metabolic engineering coupled with isoprenoid pool enhancement for committed taxanes biosynthesis in Nicotiana benthamiana
title_fullStr	Chloroplastic metabolic engineering coupled with isoprenoid pool enhancement for committed taxanes biosynthesis in Nicotiana benthamiana
title_full_unstemmed	Chloroplastic metabolic engineering coupled with isoprenoid pool enhancement for committed taxanes biosynthesis in Nicotiana benthamiana
title_sort	chloroplastic metabolic engineering coupled with isoprenoid pool enhancement for committed taxanes biosynthesis in nicotiana benthamiana
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8428c9211e514f2db08b62a0cc8920f5
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Chloroplastic metabolic engineering coupled with isoprenoid pool enhancement for committed taxanes biosynthesis in Nicotiana benthamiana

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