Design principles of the paradoxical feedback between pancreatic alpha and beta cells

Abstract Mammalian glucose homeostasis is controlled by the antagonistic hormones insulin and glucagon, secreted by pancreatic beta and alpha cells respectively. These two cell types are adjacently located in the islets of Langerhans and affect each others’ secretions in a paradoxical manner: while...

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Autores principales: Immacolata Garzilli, Shalev Itzkovitz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/842b91bfe3374bf2a79a625849f3eb22
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