ADC histograms from routine DWI for longitudinal studies in cerebral small vessel disease: a field study in CADASIL.

Diffusion tensor imaging (DTI) histogram metrics are correlated with clinical parameters in cerebral small vessel diseases (cSVD). Whether ADC histogram parameters derived from simple diffusion weighted imaging (DWI) can provide relevant markers for long term studies of cSVD remains unknown. CADASIL...

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Autores principales:	Bence Gunda, Raphael Porcher, Marco Duering, Jean-Pierre Guichard, Jerome Mawet, Eric Jouvent, Martin Dichgans, Hugues Chabriat
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/842cabf1d09142019e1b55195ea4eea2
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spelling	oai:doaj.org-article:842cabf1d09142019e1b55195ea4eea22021-11-18T08:19:46ZADC histograms from routine DWI for longitudinal studies in cerebral small vessel disease: a field study in CADASIL.1932-620310.1371/journal.pone.0097173https://doaj.org/article/842cabf1d09142019e1b55195ea4eea22014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24819368/?tool=EBIhttps://doaj.org/toc/1932-6203Diffusion tensor imaging (DTI) histogram metrics are correlated with clinical parameters in cerebral small vessel diseases (cSVD). Whether ADC histogram parameters derived from simple diffusion weighted imaging (DWI) can provide relevant markers for long term studies of cSVD remains unknown. CADASIL patients were evaluated by DWI and DTI in a large cohort study over a 6-year period. ADC histogram parameters were compared to those derived from mean diffusivity (MD) histograms in 280 patients using intra-class correlation and Bland-Altman plots. Impact of image corrections applied to ADC maps was assessed and a mixed effect model was used for analyzing the effects of scanner upgrades. The results showed that ADC histogram parameters are strongly correlated to MD histogram parameters and that image corrections have only limited influence on these results. Unexpectedly, scanner upgrades were found to have major effects on diffusion measures with DWI or DTI that can be even larger than those related to patients' characteristics. These data support that ADC histograms from daily used DWI can provide relevant parameters for assessing cSVD, but the variability related to scanner upgrades as regularly performed in clinical centers should be determined precisely for longitudinal and multicentric studies using diffusion MRI in cSVD.Bence GundaRaphael PorcherMarco DueringJean-Pierre GuichardJerome MawetEric JouventMartin DichgansHugues ChabriatPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e97173 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bence Gunda Raphael Porcher Marco Duering Jean-Pierre Guichard Jerome Mawet Eric Jouvent Martin Dichgans Hugues Chabriat ADC histograms from routine DWI for longitudinal studies in cerebral small vessel disease: a field study in CADASIL.
description	Diffusion tensor imaging (DTI) histogram metrics are correlated with clinical parameters in cerebral small vessel diseases (cSVD). Whether ADC histogram parameters derived from simple diffusion weighted imaging (DWI) can provide relevant markers for long term studies of cSVD remains unknown. CADASIL patients were evaluated by DWI and DTI in a large cohort study over a 6-year period. ADC histogram parameters were compared to those derived from mean diffusivity (MD) histograms in 280 patients using intra-class correlation and Bland-Altman plots. Impact of image corrections applied to ADC maps was assessed and a mixed effect model was used for analyzing the effects of scanner upgrades. The results showed that ADC histogram parameters are strongly correlated to MD histogram parameters and that image corrections have only limited influence on these results. Unexpectedly, scanner upgrades were found to have major effects on diffusion measures with DWI or DTI that can be even larger than those related to patients' characteristics. These data support that ADC histograms from daily used DWI can provide relevant parameters for assessing cSVD, but the variability related to scanner upgrades as regularly performed in clinical centers should be determined precisely for longitudinal and multicentric studies using diffusion MRI in cSVD.
format	article
author	Bence Gunda Raphael Porcher Marco Duering Jean-Pierre Guichard Jerome Mawet Eric Jouvent Martin Dichgans Hugues Chabriat
author_facet	Bence Gunda Raphael Porcher Marco Duering Jean-Pierre Guichard Jerome Mawet Eric Jouvent Martin Dichgans Hugues Chabriat
author_sort	Bence Gunda
title	ADC histograms from routine DWI for longitudinal studies in cerebral small vessel disease: a field study in CADASIL.
title_short	ADC histograms from routine DWI for longitudinal studies in cerebral small vessel disease: a field study in CADASIL.
title_full	ADC histograms from routine DWI for longitudinal studies in cerebral small vessel disease: a field study in CADASIL.
title_fullStr	ADC histograms from routine DWI for longitudinal studies in cerebral small vessel disease: a field study in CADASIL.
title_full_unstemmed	ADC histograms from routine DWI for longitudinal studies in cerebral small vessel disease: a field study in CADASIL.
title_sort	adc histograms from routine dwi for longitudinal studies in cerebral small vessel disease: a field study in cadasil.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/842cabf1d09142019e1b55195ea4eea2
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ADC histograms from routine DWI for longitudinal studies in cerebral small vessel disease: a field study in CADASIL.

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