Diagnostic Value of Serum and Saliva Matrix Metalloproteinase13 (MMP13) in Oral Squamous Cell Carcinoma

BACKGROUND AND OBJECTIVE: Matrix metalloproteinases (MMPs) are a group of enzymes responsible for extracellular matrix breakdown. Increased activity of type 13 is involved in invasion of oral squamous cell carcinoma. This study was performed to compare the level of matrix metalloproteinase13 (MMP13)...

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Autores principales:	T Ghanbarnia, M Seyedmajidi, M Mehryari, A Bijani, M Pooramir, R Foroughi
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2020
Materias:	oral squamous cell carcinoma matrix metalloproteinase 13 saliva serum. Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/842db9117def497990da79f49cfb2e47
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spelling	oai:doaj.org-article:842db9117def497990da79f49cfb2e472021-11-09T10:15:54ZDiagnostic Value of Serum and Saliva Matrix Metalloproteinase13 (MMP13) in Oral Squamous Cell Carcinoma1561-41072251-7170https://doaj.org/article/842db9117def497990da79f49cfb2e472020-03-01T00:00:00Zhttp://jbums.org/article-1-8810-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Matrix metalloproteinases (MMPs) are a group of enzymes responsible for extracellular matrix breakdown. Increased activity of type 13 is involved in invasion of oral squamous cell carcinoma. This study was performed to compare the level of matrix metalloproteinase13 (MMP13) in saliva and serum of patients with oral squamous cell carcinoma and healthy controls. METHODS: In this experimental in vitro study, 24 saliva and 24 serum samples were collected from patients with primary oral squamous cell carcinoma after histopathologic confirmation, whereas 21 saliva samples and 21 serum samples were collected from healthy subjects with mucosal health confirmation. Clinical examination was done for MMP-13 levels in saliva and serum, and the results were compared by ELISA. FINDINGS: MMP-13 levels in serum (7.47±2.36) and saliva (8.42±2.69) of patients with oral squamous cell carcinoma compared to healthy subjects increased respectively by 5.39±1.90 and 6.72±2.11 (P= 0.002 and P= 0.025, respectively). The levels of MMP13 in saliva and serum to determine the existence of oral squamous cell carcinoma has a "good" diagnostic value, with sensitivity and specificity of 88% and 86% respectively for serum, and 88% and 71% respectively for saliva. CONCLUSION: According to the results of this study, the levels of MMP13 in saliva and serum of patients with oral squamous cell carcinoma was higher than in healthy individuals and this biomarker had good diagnostic value in the diagnosis of oral squamous cell carcinoma.T GhanbarniaM SeyedmajidiM MehryariA BijaniM PooramirR ForoughiBabol University of Medical Sciencesarticleoral squamous cell carcinomamatrix metalloproteinase 13salivaserum.MedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 22, Iss 1, Pp 39-44 (2020)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	oral squamous cell carcinoma matrix metalloproteinase 13 saliva serum. Medicine R Medicine (General) R5-920
spellingShingle	oral squamous cell carcinoma matrix metalloproteinase 13 saliva serum. Medicine R Medicine (General) R5-920 T Ghanbarnia M Seyedmajidi M Mehryari A Bijani M Pooramir R Foroughi Diagnostic Value of Serum and Saliva Matrix Metalloproteinase13 (MMP13) in Oral Squamous Cell Carcinoma
description	BACKGROUND AND OBJECTIVE: Matrix metalloproteinases (MMPs) are a group of enzymes responsible for extracellular matrix breakdown. Increased activity of type 13 is involved in invasion of oral squamous cell carcinoma. This study was performed to compare the level of matrix metalloproteinase13 (MMP13) in saliva and serum of patients with oral squamous cell carcinoma and healthy controls. METHODS: In this experimental in vitro study, 24 saliva and 24 serum samples were collected from patients with primary oral squamous cell carcinoma after histopathologic confirmation, whereas 21 saliva samples and 21 serum samples were collected from healthy subjects with mucosal health confirmation. Clinical examination was done for MMP-13 levels in saliva and serum, and the results were compared by ELISA. FINDINGS: MMP-13 levels in serum (7.47±2.36) and saliva (8.42±2.69) of patients with oral squamous cell carcinoma compared to healthy subjects increased respectively by 5.39±1.90 and 6.72±2.11 (P= 0.002 and P= 0.025, respectively). The levels of MMP13 in saliva and serum to determine the existence of oral squamous cell carcinoma has a "good" diagnostic value, with sensitivity and specificity of 88% and 86% respectively for serum, and 88% and 71% respectively for saliva. CONCLUSION: According to the results of this study, the levels of MMP13 in saliva and serum of patients with oral squamous cell carcinoma was higher than in healthy individuals and this biomarker had good diagnostic value in the diagnosis of oral squamous cell carcinoma.
format	article
author	T Ghanbarnia M Seyedmajidi M Mehryari A Bijani M Pooramir R Foroughi
author_facet	T Ghanbarnia M Seyedmajidi M Mehryari A Bijani M Pooramir R Foroughi
author_sort	T Ghanbarnia
title	Diagnostic Value of Serum and Saliva Matrix Metalloproteinase13 (MMP13) in Oral Squamous Cell Carcinoma
title_short	Diagnostic Value of Serum and Saliva Matrix Metalloproteinase13 (MMP13) in Oral Squamous Cell Carcinoma
title_full	Diagnostic Value of Serum and Saliva Matrix Metalloproteinase13 (MMP13) in Oral Squamous Cell Carcinoma
title_fullStr	Diagnostic Value of Serum and Saliva Matrix Metalloproteinase13 (MMP13) in Oral Squamous Cell Carcinoma
title_full_unstemmed	Diagnostic Value of Serum and Saliva Matrix Metalloproteinase13 (MMP13) in Oral Squamous Cell Carcinoma
title_sort	diagnostic value of serum and saliva matrix metalloproteinase13 (mmp13) in oral squamous cell carcinoma
publisher	Babol University of Medical Sciences
publishDate	2020
url	https://doaj.org/article/842db9117def497990da79f49cfb2e47
work_keys_str_mv	AT tghanbarnia diagnosticvalueofserumandsalivamatrixmetalloproteinase13mmp13inoralsquamouscellcarcinoma AT mseyedmajidi diagnosticvalueofserumandsalivamatrixmetalloproteinase13mmp13inoralsquamouscellcarcinoma AT mmehryari diagnosticvalueofserumandsalivamatrixmetalloproteinase13mmp13inoralsquamouscellcarcinoma AT abijani diagnosticvalueofserumandsalivamatrixmetalloproteinase13mmp13inoralsquamouscellcarcinoma AT mpooramir diagnosticvalueofserumandsalivamatrixmetalloproteinase13mmp13inoralsquamouscellcarcinoma AT rforoughi diagnosticvalueofserumandsalivamatrixmetalloproteinase13mmp13inoralsquamouscellcarcinoma
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Diagnostic Value of Serum and Saliva Matrix Metalloproteinase13 (MMP13) in Oral Squamous Cell Carcinoma

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