Long-Term Visual, Refractive and Topographic Outcomes of “Epi-off” Corneal Collagen Cross-Linking in Pediatric Keratoconus: Standard versus Accelerated Protocol

Long-Term Visual, Refractive and Topographic Outcomes of “Epi-off” Corneal Collagen Cross-Linking in Pediatric Keratoconus: Standard versus Accelerated Protocol

Ibrahim Amer,1 Abdelhakeem Elaskary,1 Ali Mostafa,2 Hazem A Hazem,2 Ahmed Omar,2,3 Ahmed Abdou2 1Ophthalmology Department, Faculty of Medicine, AL-Azhar University, Assiut, Egypt; 2Ophthalmology Department, Faculty of Medicine, Assiut University, Assiut, Egypt; 3University Hospitals Eye Institute an...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Amer I, Elaskary A, Mostafa A, Hazem HA, Omar A, Abdou A
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2020
Materias:
standard cxl
accelerated cxl
corneal collagen cross-linking
pediatric keratoconus.
Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/842e22776a3849ef96cf9ac5935b1321
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:842e22776a3849ef96cf9ac5935b1321
record_format dspace
spelling oai:doaj.org-article:842e22776a3849ef96cf9ac5935b13212021-12-02T10:45:08ZLong-Term Visual, Refractive and Topographic Outcomes of “Epi-off” Corneal Collagen Cross-Linking in Pediatric Keratoconus: Standard versus Accelerated Protocol1177-5483https://doaj.org/article/842e22776a3849ef96cf9ac5935b13212020-11-01T00:00:00Zhttps://www.dovepress.com/long-term-visual-refractive-and-topographic-outcomes-of-ldquoepi-offrd-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Ibrahim Amer,1 Abdelhakeem Elaskary,1 Ali Mostafa,2 Hazem A Hazem,2 Ahmed Omar,2,3 Ahmed Abdou2 1Ophthalmology Department, Faculty of Medicine, AL-Azhar University, Assiut, Egypt; 2Ophthalmology Department, Faculty of Medicine, Assiut University, Assiut, Egypt; 3University Hospitals Eye Institute and the Department of Ophthalmology and Visual Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USACorrespondence: Ahmed AbdouOphthalmology Department, Faculty of Medicine, Assiut University, Assiut 71515, EgyptTel +201004343388Email Abdou.ahmed@aun.edu.egPurpose: To compare the visual, refractive and topographic outcomes of standard and accelerated corneal collagen cross-linking (CXL) in pediatric keratoconus patients.Methods: Prospective, comparative observational study on 68 eyes of 35 pediatric keratoconus patients (< 18 years). Patients were classified into two groups, group (I) included 34 eyes and received standard “Epi-Off” CXL (3 mW/cm2, 30 min.) and group (II) included 34 eyes and received accelerated “Epi-Off” CXL (9 mW/cm2, 10 min.). Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), spherical equivalent (SE), simulated keratometry (Sim K-1, Sim K-2, K-max, K-mean), cylindrical (CYL), pachymetry and Q-value were evaluated preoperatively and for 3 years postoperatively.Results: Postoperative UDVA and CDVA did not significantly change in both groups after 3 years. Postoperative SE was increased significantly in accelerated CXL (p=0.012) with no significant change in the postoperative cylinder in both procedures. Standard CXL had greater “significant” effect in decreasing Sim K-1, K-max and K-mean. The mean reduction in postoperative corneal pachymetry (at thinnest location) was significant in standard CXL (18.4 μm) (p=0.001). No significant change was noticed in postoperative Q-value.Conclusion: Standard and accelerated CXL protocols are efficient in pediatric keratoconus management with better outcomes in the standard procedure.Keywords: standard CXL, accelerated CXL, corneal collagen cross-linking, pediatric keratoconusAmer IElaskary AMostafa AHazem HAOmar AAbdou ADove Medical Pressarticlestandard cxlaccelerated cxlcorneal collagen cross-linkingpediatric keratoconus.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 3747-3754 (2020)
institution DOAJ
collection DOAJ
language EN
topic standard cxl
accelerated cxl
corneal collagen cross-linking
pediatric keratoconus.
Ophthalmology
RE1-994
spellingShingle standard cxl
accelerated cxl
corneal collagen cross-linking
pediatric keratoconus.
Ophthalmology
RE1-994
Amer I
Elaskary A
Mostafa A
Hazem HA
Omar A
Abdou A
Long-Term Visual, Refractive and Topographic Outcomes of “Epi-off” Corneal Collagen Cross-Linking in Pediatric Keratoconus: Standard versus Accelerated Protocol
description Ibrahim Amer,1 Abdelhakeem Elaskary,1 Ali Mostafa,2 Hazem A Hazem,2 Ahmed Omar,2,3 Ahmed Abdou2 1Ophthalmology Department, Faculty of Medicine, AL-Azhar University, Assiut, Egypt; 2Ophthalmology Department, Faculty of Medicine, Assiut University, Assiut, Egypt; 3University Hospitals Eye Institute and the Department of Ophthalmology and Visual Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USACorrespondence: Ahmed AbdouOphthalmology Department, Faculty of Medicine, Assiut University, Assiut 71515, EgyptTel +201004343388Email Abdou.ahmed@aun.edu.egPurpose: To compare the visual, refractive and topographic outcomes of standard and accelerated corneal collagen cross-linking (CXL) in pediatric keratoconus patients.Methods: Prospective, comparative observational study on 68 eyes of 35 pediatric keratoconus patients (< 18 years). Patients were classified into two groups, group (I) included 34 eyes and received standard “Epi-Off” CXL (3 mW/cm2, 30 min.) and group (II) included 34 eyes and received accelerated “Epi-Off” CXL (9 mW/cm2, 10 min.). Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), spherical equivalent (SE), simulated keratometry (Sim K-1, Sim K-2, K-max, K-mean), cylindrical (CYL), pachymetry and Q-value were evaluated preoperatively and for 3 years postoperatively.Results: Postoperative UDVA and CDVA did not significantly change in both groups after 3 years. Postoperative SE was increased significantly in accelerated CXL (p=0.012) with no significant change in the postoperative cylinder in both procedures. Standard CXL had greater “significant” effect in decreasing Sim K-1, K-max and K-mean. The mean reduction in postoperative corneal pachymetry (at thinnest location) was significant in standard CXL (18.4 μm) (p=0.001). No significant change was noticed in postoperative Q-value.Conclusion: Standard and accelerated CXL protocols are efficient in pediatric keratoconus management with better outcomes in the standard procedure.Keywords: standard CXL, accelerated CXL, corneal collagen cross-linking, pediatric keratoconus
format article
author Amer I
Elaskary A
Mostafa A
Hazem HA
Omar A
Abdou A
author_facet Amer I
Elaskary A
Mostafa A
Hazem HA
Omar A
Abdou A
author_sort Amer I
title Long-Term Visual, Refractive and Topographic Outcomes of “Epi-off” Corneal Collagen Cross-Linking in Pediatric Keratoconus: Standard versus Accelerated Protocol
title_short Long-Term Visual, Refractive and Topographic Outcomes of “Epi-off” Corneal Collagen Cross-Linking in Pediatric Keratoconus: Standard versus Accelerated Protocol
title_full Long-Term Visual, Refractive and Topographic Outcomes of “Epi-off” Corneal Collagen Cross-Linking in Pediatric Keratoconus: Standard versus Accelerated Protocol
title_fullStr Long-Term Visual, Refractive and Topographic Outcomes of “Epi-off” Corneal Collagen Cross-Linking in Pediatric Keratoconus: Standard versus Accelerated Protocol
title_full_unstemmed Long-Term Visual, Refractive and Topographic Outcomes of “Epi-off” Corneal Collagen Cross-Linking in Pediatric Keratoconus: Standard versus Accelerated Protocol
title_sort long-term visual, refractive and topographic outcomes of “epi-off” corneal collagen cross-linking in pediatric keratoconus: standard versus accelerated protocol
publisher Dove Medical Press
publishDate 2020
url https://doaj.org/article/842e22776a3849ef96cf9ac5935b1321
work_keys_str_mv AT ameri longtermvisualrefractiveandtopographicoutcomesofldquoepioffrdquocornealcollagencrosslinkinginpediatrickeratoconusstandardversusacceleratedprotocol
AT elaskarya longtermvisualrefractiveandtopographicoutcomesofldquoepioffrdquocornealcollagencrosslinkinginpediatrickeratoconusstandardversusacceleratedprotocol
AT mostafaa longtermvisualrefractiveandtopographicoutcomesofldquoepioffrdquocornealcollagencrosslinkinginpediatrickeratoconusstandardversusacceleratedprotocol
AT hazemha longtermvisualrefractiveandtopographicoutcomesofldquoepioffrdquocornealcollagencrosslinkinginpediatrickeratoconusstandardversusacceleratedprotocol
AT omara longtermvisualrefractiveandtopographicoutcomesofldquoepioffrdquocornealcollagencrosslinkinginpediatrickeratoconusstandardversusacceleratedprotocol
AT abdoua longtermvisualrefractiveandtopographicoutcomesofldquoepioffrdquocornealcollagencrosslinkinginpediatrickeratoconusstandardversusacceleratedprotocol
_version_ 1718396772567482368

Ejemplares similares