Bladder Recurrence Following the Treatment of Upper Tract Urothelial Carcinoma

Objective: Although, upper tract urothelial carcinoma (UTUC) is rare it is associated with a high mortality rate and frequently, followed by bladder recurrence after radical surgery. Hence, this study aimed to identify the rate of bladder recurrence and its predictive factors. Material and Methods:...

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Autores principales:	Takarn Itsaranujareankul, Kanrapee Nuwatkrisin, Kamol Panumatrassamee, Dutsadee Sowanthip, Julin Opanuraks, Supoj Ratchanon, Apirak Santingamkun, Manint Usawachintachit
Formato:	article
Lenguaje:	EN
Publicado:	Prince of Songkla University 2021
Materias:	bladder recurrence nephroureterectomy upper tract urothelial carcinoma Medicine R
Acceso en línea:	https://doaj.org/article/8431370ab37643cf964583a055583376
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spelling	oai:doaj.org-article:8431370ab37643cf964583a0555833762021-11-25T08:25:12ZBladder Recurrence Following the Treatment of Upper Tract Urothelial Carcinoma2586-99812630-055910.31584/jhsmr.2021807https://doaj.org/article/8431370ab37643cf964583a0555833762021-11-01T00:00:00Zhttps://www.jhsmr.org/index.php/jhsmr/article/view/807https://doaj.org/toc/2586-9981https://doaj.org/toc/2630-0559Objective: Although, upper tract urothelial carcinoma (UTUC) is rare it is associated with a high mortality rate and frequently, followed by bladder recurrence after radical surgery. Hence, this study aimed to identify the rate of bladder recurrence and its predictive factors. Material and Methods: We reviewed the medical records of 104 patients, who were diagnosed with UTUC and had radical nephroureterectomy (RNU), at the King Chulalongkorn Memorial Hospital. We excluded patients who have concurrent bladder cancer, or had a history of bladder cancer. Various clinicopathological factors were analyzed using the log-rank test and Cox proportional hazard model. Results: The mean age at diagnosis of UTUC was 68 years, and one-third of the patients were diagnosed with pathological T3 (33.7%). The mean follow-up duration was 56 months. Bladder recurrence occurred in 39 out of 104 patients (37.5%), and the median time to recurrence was 5.8 months (interquartile range 3.6 to 11.0 months). Tumor location in the distal ureter (p-value=0.038) and history of diagnostic ureteroscopy (p-value=0.004) were significantly associated with bladder recurrence in the univariate model. However, only the history of diagnostic ureteroscopy remained significant in the multivariate analysis (p-value=0.023). Conclusion: Bladder recurrence, following RNU, occurs in one-third of patients. Potential predictive factors may include history of diagnostic ureteroscopy, and the tumor location being in the distal ureter.Takarn ItsaranujareankulKanrapee NuwatkrisinKamol PanumatrassameeDutsadee SowanthipJulin OpanuraksSupoj RatchanonApirak SantingamkunManint UsawachintachitPrince of Songkla Universityarticlebladder recurrencenephroureterectomyupper tract urothelial carcinomaMedicineRENJournal of Health Science and Medical Research (JHSMR), Vol 40, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bladder recurrence nephroureterectomy upper tract urothelial carcinoma Medicine R
spellingShingle	bladder recurrence nephroureterectomy upper tract urothelial carcinoma Medicine R Takarn Itsaranujareankul Kanrapee Nuwatkrisin Kamol Panumatrassamee Dutsadee Sowanthip Julin Opanuraks Supoj Ratchanon Apirak Santingamkun Manint Usawachintachit Bladder Recurrence Following the Treatment of Upper Tract Urothelial Carcinoma
description	Objective: Although, upper tract urothelial carcinoma (UTUC) is rare it is associated with a high mortality rate and frequently, followed by bladder recurrence after radical surgery. Hence, this study aimed to identify the rate of bladder recurrence and its predictive factors. Material and Methods: We reviewed the medical records of 104 patients, who were diagnosed with UTUC and had radical nephroureterectomy (RNU), at the King Chulalongkorn Memorial Hospital. We excluded patients who have concurrent bladder cancer, or had a history of bladder cancer. Various clinicopathological factors were analyzed using the log-rank test and Cox proportional hazard model. Results: The mean age at diagnosis of UTUC was 68 years, and one-third of the patients were diagnosed with pathological T3 (33.7%). The mean follow-up duration was 56 months. Bladder recurrence occurred in 39 out of 104 patients (37.5%), and the median time to recurrence was 5.8 months (interquartile range 3.6 to 11.0 months). Tumor location in the distal ureter (p-value=0.038) and history of diagnostic ureteroscopy (p-value=0.004) were significantly associated with bladder recurrence in the univariate model. However, only the history of diagnostic ureteroscopy remained significant in the multivariate analysis (p-value=0.023). Conclusion: Bladder recurrence, following RNU, occurs in one-third of patients. Potential predictive factors may include history of diagnostic ureteroscopy, and the tumor location being in the distal ureter.
format	article
author	Takarn Itsaranujareankul Kanrapee Nuwatkrisin Kamol Panumatrassamee Dutsadee Sowanthip Julin Opanuraks Supoj Ratchanon Apirak Santingamkun Manint Usawachintachit
author_facet	Takarn Itsaranujareankul Kanrapee Nuwatkrisin Kamol Panumatrassamee Dutsadee Sowanthip Julin Opanuraks Supoj Ratchanon Apirak Santingamkun Manint Usawachintachit
author_sort	Takarn Itsaranujareankul
title	Bladder Recurrence Following the Treatment of Upper Tract Urothelial Carcinoma
title_short	Bladder Recurrence Following the Treatment of Upper Tract Urothelial Carcinoma
title_full	Bladder Recurrence Following the Treatment of Upper Tract Urothelial Carcinoma
title_fullStr	Bladder Recurrence Following the Treatment of Upper Tract Urothelial Carcinoma
title_full_unstemmed	Bladder Recurrence Following the Treatment of Upper Tract Urothelial Carcinoma
title_sort	bladder recurrence following the treatment of upper tract urothelial carcinoma
publisher	Prince of Songkla University
publishDate	2021
url	https://doaj.org/article/8431370ab37643cf964583a055583376
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_version_	1718413568719716352

Bladder Recurrence Following the Treatment of Upper Tract Urothelial Carcinoma

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