Effect of Diltiazem on the growth of long bones in rats

Objective: Diltiazem is a calcium channel-blocking agent. In this study effect of Diltiazem on the ossification and the linear growth of rat’s long bones of one, two and three months age was examined. Methods: Rats were weighed and marked and Diltiazem was administered as follows: A) One month old,...

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Autores principales:	A Arzi, H Rashidi, S Farjad Nia
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2000
Materias:	calcium channel blocker ossification diltiazem long bones Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/84332d3e69094e42a1de2cdb332ec543
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id	oai:doaj.org-article:84332d3e69094e42a1de2cdb332ec543
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spelling	oai:doaj.org-article:84332d3e69094e42a1de2cdb332ec5432021-11-10T09:21:59ZEffect of Diltiazem on the growth of long bones in rats1561-41072251-7170https://doaj.org/article/84332d3e69094e42a1de2cdb332ec5432000-01-01T00:00:00Zhttp://jbums.org/article-1-2926-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Objective: Diltiazem is a calcium channel-blocking agent. In this study effect of Diltiazem on the ossification and the linear growth of rat’s long bones of one, two and three months age was examined. Methods: Rats were weighed and marked and Diltiazem was administered as follows: A) One month old, 2 mg/kg/day, for one week. B) Two months old, 3 mg/kg/day, for one week. C) Three months old, 4 mg/kg/day, for one week. D) Three months old, 4 mg/kg/day, for two weeks. E) Three months old, 8 mg/kg/day, for two weeks. The same number of rats were used as control group (A, B, C, D, E) for each group, they received distilled water. At the end of drug administration, after studying the condition of animals, those, which showed noticeable differences in body skeleton, were chosen for radiographic investigation. Then the rats were sacrificed and the length of their long bones was measured and finally we conducted microscopic study of femur bone of test and control groups. Findings: The results of this study showed that: 1) There was an increase in the number of chondrocytes in growth plate which was accompanied with a decrease in calcification and ossification. 2) The length, curvature, diameter and weight of long bones increased, 3) The bone damage and osteoporosis in all treatment groups were seen. Conclusion: Due to basic role of calcium in osteoporosis during growth period, exposure with calcium channel blockers such as Diltiazem could be dangerous.A ArziH RashidiS Farjad NiaBabol University of Medical Sciencesarticlecalcium channel blockerossificationdiltiazemlong bonesMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 2, Iss 1, Pp 8-14 (2000)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	calcium channel blocker ossification diltiazem long bones Medicine R Medicine (General) R5-920
spellingShingle	calcium channel blocker ossification diltiazem long bones Medicine R Medicine (General) R5-920 A Arzi H Rashidi S Farjad Nia Effect of Diltiazem on the growth of long bones in rats
description	Objective: Diltiazem is a calcium channel-blocking agent. In this study effect of Diltiazem on the ossification and the linear growth of rat’s long bones of one, two and three months age was examined. Methods: Rats were weighed and marked and Diltiazem was administered as follows: A) One month old, 2 mg/kg/day, for one week. B) Two months old, 3 mg/kg/day, for one week. C) Three months old, 4 mg/kg/day, for one week. D) Three months old, 4 mg/kg/day, for two weeks. E) Three months old, 8 mg/kg/day, for two weeks. The same number of rats were used as control group (A, B, C, D, E) for each group, they received distilled water. At the end of drug administration, after studying the condition of animals, those, which showed noticeable differences in body skeleton, were chosen for radiographic investigation. Then the rats were sacrificed and the length of their long bones was measured and finally we conducted microscopic study of femur bone of test and control groups. Findings: The results of this study showed that: 1) There was an increase in the number of chondrocytes in growth plate which was accompanied with a decrease in calcification and ossification. 2) The length, curvature, diameter and weight of long bones increased, 3) The bone damage and osteoporosis in all treatment groups were seen. Conclusion: Due to basic role of calcium in osteoporosis during growth period, exposure with calcium channel blockers such as Diltiazem could be dangerous.
format	article
author	A Arzi H Rashidi S Farjad Nia
author_facet	A Arzi H Rashidi S Farjad Nia
author_sort	A Arzi
title	Effect of Diltiazem on the growth of long bones in rats
title_short	Effect of Diltiazem on the growth of long bones in rats
title_full	Effect of Diltiazem on the growth of long bones in rats
title_fullStr	Effect of Diltiazem on the growth of long bones in rats
title_full_unstemmed	Effect of Diltiazem on the growth of long bones in rats
title_sort	effect of diltiazem on the growth of long bones in rats
publisher	Babol University of Medical Sciences
publishDate	2000
url	https://doaj.org/article/84332d3e69094e42a1de2cdb332ec543
work_keys_str_mv	AT aarzi effectofdiltiazemonthegrowthoflongbonesinrats AT hrashidi effectofdiltiazemonthegrowthoflongbonesinrats AT sfarjadnia effectofdiltiazemonthegrowthoflongbonesinrats
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Effect of Diltiazem on the growth of long bones in rats

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