Effect of kiwifruit on metabolic health in patients with cardiovascular risk factors: a systematic review and meta-analysis

Naeti Suksomboon,1 Nalinee Poolsup,2 Wei Lin1 1Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand; 2Department of Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand Background: Kiwifruit seems to have beneficial effect on metabolic health bec...

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Autores principales:	Suksomboon N, Poolsup N, Lin W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Actinidia Metabolic diseases Lipid Cholesterol Blood glucose Blood pressure Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/8435de0cec38406494cef226302d5a74
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spelling	oai:doaj.org-article:8435de0cec38406494cef226302d5a742021-12-02T02:38:15ZEffect of kiwifruit on metabolic health in patients with cardiovascular risk factors: a systematic review and meta-analysis1178-7007https://doaj.org/article/8435de0cec38406494cef226302d5a742019-01-01T00:00:00Zhttps://www.dovepress.com/effect-of-kiwifruit-on-metabolic-health-in-patients-with-cardiovascula-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Naeti Suksomboon,1 Nalinee Poolsup,2 Wei Lin1 1Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand; 2Department of Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand Background: Kiwifruit seems to have beneficial effect on metabolic health because it contains abundant phytochemicals and antioxidants. This study aimed to assess the effect of kiwifruit on metabolic health in participants with cardiovascular risk factors.Methods: Literature was searched from PubMed, CENTRAL, Cumulative Index to Nursing and Allied Health Literature, Web of Science, Scopus, Proquest, Latin American and Caribbean Health Sciences Literature, International Clinical Trials Registry Platform, Australia New Zealand Clinical Trials Registry, https://clinicaltrials.gov/, China National Knowledge Infrastructure, Wanfang Standards Database, European Association for the Study of Diabetes, and American Diabetes Association conferences up to August 2018. Citing references were manually searched. Randomized controlled trials were selected if they evaluated the effect of kiwifruit in patients with cardiovascular risk factors and reported SBP, DBP, total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), glycated hemoglobin (A1C), fasting plasma glucose (FPG), homeostasis model assessment of insulin resistance (HOMA-IR), 2-hour postprandial glucose, or body weight (BW). Data extraction and study quality assessment were performed independently by two investigators. Any inconsistencies were resolved by a third investigator. Treatment effect was estimated with mean difference (MD). Effect estimates were pooled using inverse-variance weighted method. Heterogeneity was assessed by the I2 and Q statistic.Results: Five randomized controlled trials involving 489 participants met the inclusion criteria. These included hypercholesterolemia, hypertension, type 2 diabetes mellitus, and male smokers. There was no effect of kiwifruit on SBP (MD, –1.72 mmHg; 95% CI: –4.27 to 0.84); DBP (MD, –2.35 mmHg; 95% CI: –5.10 to 0.41); TC (MD, –0.14 mmol/L; 95% CI: –0.71 to 0.43); TG (MD, –0.23 mmol/L; 95% CI: –0.66 to 0.20); LDL-C (MD, –0.41 mmol/L; 95% CI: –0.99 to 0.18); HDL-C (MD, 0.15 mmol/L; 95% CI: –0.18 to 0.48); FPG (MD, –0.08 mmol/L; 95% CI: –0.37 to 0.21); HOMA-IR (MD, –0.29; 95% CI: –0.61 to 0.02), and BW (MD, –1.08 kg; 95% CI: –4.22 to 2.05).Conclusion: This meta-analysis suggested no effect of kiwifruit on metabolic health in patients with cardiovascular risk factors, although there seemed to be a trend of improvement after kiwifruit intervention. Keywords:  Actinidia, metabolic diseases, lipid, cholesterol, blood glucose, blood pressureSuksomboon NPoolsup NLin WDove Medical PressarticleActinidiaMetabolic diseasesLipidCholesterolBlood glucoseBlood pressureSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 171-180 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Actinidia Metabolic diseases Lipid Cholesterol Blood glucose Blood pressure Specialties of internal medicine RC581-951
spellingShingle	Actinidia Metabolic diseases Lipid Cholesterol Blood glucose Blood pressure Specialties of internal medicine RC581-951 Suksomboon N Poolsup N Lin W Effect of kiwifruit on metabolic health in patients with cardiovascular risk factors: a systematic review and meta-analysis
description	Naeti Suksomboon,1 Nalinee Poolsup,2 Wei Lin1 1Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand; 2Department of Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand Background: Kiwifruit seems to have beneficial effect on metabolic health because it contains abundant phytochemicals and antioxidants. This study aimed to assess the effect of kiwifruit on metabolic health in participants with cardiovascular risk factors.Methods: Literature was searched from PubMed, CENTRAL, Cumulative Index to Nursing and Allied Health Literature, Web of Science, Scopus, Proquest, Latin American and Caribbean Health Sciences Literature, International Clinical Trials Registry Platform, Australia New Zealand Clinical Trials Registry, https://clinicaltrials.gov/, China National Knowledge Infrastructure, Wanfang Standards Database, European Association for the Study of Diabetes, and American Diabetes Association conferences up to August 2018. Citing references were manually searched. Randomized controlled trials were selected if they evaluated the effect of kiwifruit in patients with cardiovascular risk factors and reported SBP, DBP, total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), glycated hemoglobin (A1C), fasting plasma glucose (FPG), homeostasis model assessment of insulin resistance (HOMA-IR), 2-hour postprandial glucose, or body weight (BW). Data extraction and study quality assessment were performed independently by two investigators. Any inconsistencies were resolved by a third investigator. Treatment effect was estimated with mean difference (MD). Effect estimates were pooled using inverse-variance weighted method. Heterogeneity was assessed by the I2 and Q statistic.Results: Five randomized controlled trials involving 489 participants met the inclusion criteria. These included hypercholesterolemia, hypertension, type 2 diabetes mellitus, and male smokers. There was no effect of kiwifruit on SBP (MD, –1.72 mmHg; 95% CI: –4.27 to 0.84); DBP (MD, –2.35 mmHg; 95% CI: –5.10 to 0.41); TC (MD, –0.14 mmol/L; 95% CI: –0.71 to 0.43); TG (MD, –0.23 mmol/L; 95% CI: –0.66 to 0.20); LDL-C (MD, –0.41 mmol/L; 95% CI: –0.99 to 0.18); HDL-C (MD, 0.15 mmol/L; 95% CI: –0.18 to 0.48); FPG (MD, –0.08 mmol/L; 95% CI: –0.37 to 0.21); HOMA-IR (MD, –0.29; 95% CI: –0.61 to 0.02), and BW (MD, –1.08 kg; 95% CI: –4.22 to 2.05).Conclusion: This meta-analysis suggested no effect of kiwifruit on metabolic health in patients with cardiovascular risk factors, although there seemed to be a trend of improvement after kiwifruit intervention. Keywords:  Actinidia, metabolic diseases, lipid, cholesterol, blood glucose, blood pressure
format	article
author	Suksomboon N Poolsup N Lin W
author_facet	Suksomboon N Poolsup N Lin W
author_sort	Suksomboon N
title	Effect of kiwifruit on metabolic health in patients with cardiovascular risk factors: a systematic review and meta-analysis
title_short	Effect of kiwifruit on metabolic health in patients with cardiovascular risk factors: a systematic review and meta-analysis
title_full	Effect of kiwifruit on metabolic health in patients with cardiovascular risk factors: a systematic review and meta-analysis
title_fullStr	Effect of kiwifruit on metabolic health in patients with cardiovascular risk factors: a systematic review and meta-analysis
title_full_unstemmed	Effect of kiwifruit on metabolic health in patients with cardiovascular risk factors: a systematic review and meta-analysis
title_sort	effect of kiwifruit on metabolic health in patients with cardiovascular risk factors: a systematic review and meta-analysis
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/8435de0cec38406494cef226302d5a74
work_keys_str_mv	AT suksomboonn effectofkiwifruitonmetabolichealthinpatientswithcardiovascularriskfactorsasystematicreviewandmetaanalysis AT poolsupn effectofkiwifruitonmetabolichealthinpatientswithcardiovascularriskfactorsasystematicreviewandmetaanalysis AT linw effectofkiwifruitonmetabolichealthinpatientswithcardiovascularriskfactorsasystematicreviewandmetaanalysis
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Effect of kiwifruit on metabolic health in patients with cardiovascular risk factors: a systematic review and meta-analysis

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