Streamlined copper defenses make Bordetella pertussis reliant on custom-made operon

Alex Rivera-Millot et al. investigate copper homeostasis in the whooping cough agent Bordetella pertussis, which has a single copper defense mechanism via a metallochaperone diverted for copper passivation and two peroxide detoxification enzymes. This study demonstrates that copper up-regulates the...

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Autores principales:	Alex Rivera-Millot, Stéphanie Slupek, Jonathan Chatagnon, Gauthier Roy, Jean-Michel Saliou, Gabriel Billon, Véronique Alaimo, David Hot, Sophie Salomé-Desnoulez, Camille Locht, Rudy Antoine, Françoise Jacob-Dubuisson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8437a2a6d9fa42868f9b6a88b4736a8a
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spelling	oai:doaj.org-article:8437a2a6d9fa42868f9b6a88b4736a8a2021-12-02T15:07:31ZStreamlined copper defenses make Bordetella pertussis reliant on custom-made operon10.1038/s42003-020-01580-22399-3642https://doaj.org/article/8437a2a6d9fa42868f9b6a88b4736a8a2021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01580-2https://doaj.org/toc/2399-3642Alex Rivera-Millot et al. investigate copper homeostasis in the whooping cough agent Bordetella pertussis, which has a single copper defense mechanism via a metallochaperone diverted for copper passivation and two peroxide detoxification enzymes. This study demonstrates that copper up-regulates the copZ-prxgrx-gorB operon in macrophages, and this system appears to contribute to persistent infection in the nasal cavity of B. pertussis-infected mice. This study brings insight into strategies aimed to optimize survival of a host-restricted pathogen.Alex Rivera-MillotStéphanie SlupekJonathan ChatagnonGauthier RoyJean-Michel SaliouGabriel BillonVéronique AlaimoDavid HotSophie Salomé-DesnoulezCamille LochtRudy AntoineFrançoise Jacob-DubuissonNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Alex Rivera-Millot Stéphanie Slupek Jonathan Chatagnon Gauthier Roy Jean-Michel Saliou Gabriel Billon Véronique Alaimo David Hot Sophie Salomé-Desnoulez Camille Locht Rudy Antoine Françoise Jacob-Dubuisson Streamlined copper defenses make Bordetella pertussis reliant on custom-made operon
description	Alex Rivera-Millot et al. investigate copper homeostasis in the whooping cough agent Bordetella pertussis, which has a single copper defense mechanism via a metallochaperone diverted for copper passivation and two peroxide detoxification enzymes. This study demonstrates that copper up-regulates the copZ-prxgrx-gorB operon in macrophages, and this system appears to contribute to persistent infection in the nasal cavity of B. pertussis-infected mice. This study brings insight into strategies aimed to optimize survival of a host-restricted pathogen.
format	article
author	Alex Rivera-Millot Stéphanie Slupek Jonathan Chatagnon Gauthier Roy Jean-Michel Saliou Gabriel Billon Véronique Alaimo David Hot Sophie Salomé-Desnoulez Camille Locht Rudy Antoine Françoise Jacob-Dubuisson
author_facet	Alex Rivera-Millot Stéphanie Slupek Jonathan Chatagnon Gauthier Roy Jean-Michel Saliou Gabriel Billon Véronique Alaimo David Hot Sophie Salomé-Desnoulez Camille Locht Rudy Antoine Françoise Jacob-Dubuisson
author_sort	Alex Rivera-Millot
title	Streamlined copper defenses make Bordetella pertussis reliant on custom-made operon
title_short	Streamlined copper defenses make Bordetella pertussis reliant on custom-made operon
title_full	Streamlined copper defenses make Bordetella pertussis reliant on custom-made operon
title_fullStr	Streamlined copper defenses make Bordetella pertussis reliant on custom-made operon
title_full_unstemmed	Streamlined copper defenses make Bordetella pertussis reliant on custom-made operon
title_sort	streamlined copper defenses make bordetella pertussis reliant on custom-made operon
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8437a2a6d9fa42868f9b6a88b4736a8a
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Streamlined copper defenses make Bordetella pertussis reliant on custom-made operon

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