A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors

BAFF is an important cytokine for B cell survival, and is a therapeutic target for autoimmune disorders. Here the authors show that a 'flap' region of BAFF converts BAFFR binding events into survival signals and, with structural data, that this ‘flap’ differentially modulates binding of dr...

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Autores principales:	Michele Vigolo, Melissa G. Chambers, Laure Willen, Dehlia Chevalley, Klaus Maskos, Alfred Lammens, Aubry Tardivel, Dolon Das, Christine Kowalczyk-Quintas, Sonia Schuepbach-Mallepell, Cristian R. Smulski, Mahya Eslami, Antonius Rolink, Edith Hummler, Eileen Samy, Yves Fomekong Nanfack, Fabienne Mackay, Maofu Liao, Henry Hess, Xuliang Jiang, Pascal Schneider
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/843bbc0b96a640bc806daedcfd909b7b
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spelling	oai:doaj.org-article:843bbc0b96a640bc806daedcfd909b7b2021-12-02T14:40:03ZA loop region of BAFF controls B cell survival and regulates recognition by different inhibitors10.1038/s41467-018-03323-82041-1723https://doaj.org/article/843bbc0b96a640bc806daedcfd909b7b2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03323-8https://doaj.org/toc/2041-1723BAFF is an important cytokine for B cell survival, and is a therapeutic target for autoimmune disorders. Here the authors show that a 'flap' region of BAFF converts BAFFR binding events into survival signals and, with structural data, that this ‘flap’ differentially modulates binding of drugs such as belimumab or atacicept.Michele VigoloMelissa G. ChambersLaure WillenDehlia ChevalleyKlaus MaskosAlfred LammensAubry TardivelDolon DasChristine Kowalczyk-QuintasSonia Schuepbach-MallepellCristian R. SmulskiMahya EslamiAntonius RolinkEdith HummlerEileen SamyYves Fomekong NanfackFabienne MackayMaofu LiaoHenry HessXuliang JiangPascal SchneiderNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michele Vigolo Melissa G. Chambers Laure Willen Dehlia Chevalley Klaus Maskos Alfred Lammens Aubry Tardivel Dolon Das Christine Kowalczyk-Quintas Sonia Schuepbach-Mallepell Cristian R. Smulski Mahya Eslami Antonius Rolink Edith Hummler Eileen Samy Yves Fomekong Nanfack Fabienne Mackay Maofu Liao Henry Hess Xuliang Jiang Pascal Schneider A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors
description	BAFF is an important cytokine for B cell survival, and is a therapeutic target for autoimmune disorders. Here the authors show that a 'flap' region of BAFF converts BAFFR binding events into survival signals and, with structural data, that this ‘flap’ differentially modulates binding of drugs such as belimumab or atacicept.
format	article
author	Michele Vigolo Melissa G. Chambers Laure Willen Dehlia Chevalley Klaus Maskos Alfred Lammens Aubry Tardivel Dolon Das Christine Kowalczyk-Quintas Sonia Schuepbach-Mallepell Cristian R. Smulski Mahya Eslami Antonius Rolink Edith Hummler Eileen Samy Yves Fomekong Nanfack Fabienne Mackay Maofu Liao Henry Hess Xuliang Jiang Pascal Schneider
author_facet	Michele Vigolo Melissa G. Chambers Laure Willen Dehlia Chevalley Klaus Maskos Alfred Lammens Aubry Tardivel Dolon Das Christine Kowalczyk-Quintas Sonia Schuepbach-Mallepell Cristian R. Smulski Mahya Eslami Antonius Rolink Edith Hummler Eileen Samy Yves Fomekong Nanfack Fabienne Mackay Maofu Liao Henry Hess Xuliang Jiang Pascal Schneider
author_sort	Michele Vigolo
title	A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors
title_short	A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors
title_full	A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors
title_fullStr	A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors
title_full_unstemmed	A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors
title_sort	loop region of baff controls b cell survival and regulates recognition by different inhibitors
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/843bbc0b96a640bc806daedcfd909b7b
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A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors

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