Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair

In normal skin, Notch directs keratinocytes to terminally differentiate. Here the authors show that Notch1 has a wider role in skin repair; Notch1 is activated in keratinocytes after damage and drives transcription of TNFα and inflammatory chemokines, which in turn recruit ILC3s and macrophages that...

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Autores principales:	Zhi Li, Tom Hodgkinson, Elizabeth J. Gothard, Soulmaz Boroumand, Rebecca Lamb, Ian Cummins, Priyanka Narang, Amy Sawtell, Jenny Coles, German Leonov, Andrea Reboldi, Christopher D. Buckley, Tom Cupedo, Christian Siebel, Ardeshir Bayat, Mark C. Coles, Carrie A. Ambler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/843bd1d443c040959d4e14ce28f79819
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spelling	oai:doaj.org-article:843bd1d443c040959d4e14ce28f798192021-12-02T16:50:15ZEpidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair10.1038/ncomms113942041-1723https://doaj.org/article/843bd1d443c040959d4e14ce28f798192016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11394https://doaj.org/toc/2041-1723In normal skin, Notch directs keratinocytes to terminally differentiate. Here the authors show that Notch1 has a wider role in skin repair; Notch1 is activated in keratinocytes after damage and drives transcription of TNFα and inflammatory chemokines, which in turn recruit ILC3s and macrophages that promote repair.Zhi LiTom HodgkinsonElizabeth J. GothardSoulmaz BoroumandRebecca LambIan CumminsPriyanka NarangAmy SawtellJenny ColesGerman LeonovAndrea ReboldiChristopher D. BuckleyTom CupedoChristian SiebelArdeshir BayatMark C. ColesCarrie A. AmblerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhi Li Tom Hodgkinson Elizabeth J. Gothard Soulmaz Boroumand Rebecca Lamb Ian Cummins Priyanka Narang Amy Sawtell Jenny Coles German Leonov Andrea Reboldi Christopher D. Buckley Tom Cupedo Christian Siebel Ardeshir Bayat Mark C. Coles Carrie A. Ambler Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair
description	In normal skin, Notch directs keratinocytes to terminally differentiate. Here the authors show that Notch1 has a wider role in skin repair; Notch1 is activated in keratinocytes after damage and drives transcription of TNFα and inflammatory chemokines, which in turn recruit ILC3s and macrophages that promote repair.
format	article
author	Zhi Li Tom Hodgkinson Elizabeth J. Gothard Soulmaz Boroumand Rebecca Lamb Ian Cummins Priyanka Narang Amy Sawtell Jenny Coles German Leonov Andrea Reboldi Christopher D. Buckley Tom Cupedo Christian Siebel Ardeshir Bayat Mark C. Coles Carrie A. Ambler
author_facet	Zhi Li Tom Hodgkinson Elizabeth J. Gothard Soulmaz Boroumand Rebecca Lamb Ian Cummins Priyanka Narang Amy Sawtell Jenny Coles German Leonov Andrea Reboldi Christopher D. Buckley Tom Cupedo Christian Siebel Ardeshir Bayat Mark C. Coles Carrie A. Ambler
author_sort	Zhi Li
title	Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair
title_short	Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair
title_full	Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair
title_fullStr	Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair
title_full_unstemmed	Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair
title_sort	epidermal notch1 recruits rorγ+ group 3 innate lymphoid cells to orchestrate normal skin repair
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/843bd1d443c040959d4e14ce28f79819
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Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair

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