Therapeutic Effects and Safe Uses of Plant-Derived Polyphenolic Compounds in Cardiovascular Diseases: A Review

Badriyah Shadid Alotaibi,1 Munazza Ijaz,2 Manal Buabeid,3,4 Zelal Jaber Kharaba,5 Hafiza Sidra Yaseen,6 Ghulam Murtaza6 1Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia; 2Institute of Molecular Biology and Biotechnology, T...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Alotaibi BS, Ijaz M, Buabeid M, Kharaba ZJ, Yaseen HS, Murtaza G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	cardiovascular diseases polyphenols clinical trials cardioprotective antioxidant Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/844674c3a6b44f0dadbabe38ca42cd1b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:844674c3a6b44f0dadbabe38ca42cd1b
record_format	dspace
spelling	oai:doaj.org-article:844674c3a6b44f0dadbabe38ca42cd1b2021-11-21T19:08:51ZTherapeutic Effects and Safe Uses of Plant-Derived Polyphenolic Compounds in Cardiovascular Diseases: A Review1177-8881https://doaj.org/article/844674c3a6b44f0dadbabe38ca42cd1b2021-11-01T00:00:00Zhttps://www.dovepress.com/therapeutic-effects-and-safe-uses-of-plant-derived-polyphenolic-compou-peer-reviewed-fulltext-article-DDDThttps://doaj.org/toc/1177-8881Badriyah Shadid Alotaibi,1 Munazza Ijaz,2 Manal Buabeid,3,4 Zelal Jaber Kharaba,5 Hafiza Sidra Yaseen,6 Ghulam Murtaza6 1Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia; 2Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan; 3Medical and Bio-Allied Health Sciences Research Centre, Ajman University, Ajman, United Arab Emirates; 4Department of Clinical Sciences, Ajman University, Ajman, 346, United Arab Emirates; 5Department of Clinical Sciences, College of Pharmacy, Al-Ain University of Science and Technology, Abu Dhabi, United Arab Emirates; 6Department of Pharmacy, COMSATS University Islamabad, Lahore Campus, Lahore, 54000, PakistanCorrespondence: Manal Buabeid; Ghulam Murtaza Tel +92 3215129950Fax +92 992-383441Email m.buabeid@ajman.ac.ae; gmdogar356@gmail.comAbstract: Polyphenols have long been recognized as health-promoting entities, including beneficial effects on cardiovascular disease, but their reputation has been boosted recently following a number of encouraging clinical studies in multiple chronic pathologies, that seem to validate efficacy. Health benefits of polyphenols have been linked to their well-established powerful antioxidant activity. This review aims to provide comprehensive and up-to-date knowledge on the current therapeutic status of polyphenols having sufficient heed towards the treatment of cardiovascular diseases. Furthermore, data about the safety profile of highly efficacious polyphenols has also been investigated to further enhance their role in cardiac abnormalities. Evidence is presented to support the action of phenolic derivatives against cardiovascular pathologies by following receptors and signaling pathways which ultimately cause changes in endogenous antioxidant, antiplatelet, vasodilatory, and anti-inflammatory activities. In addition, in vitro antioxidant and pre-clinical and clinical experiments on anti-inflammatory as well as immunomodulatory attributes of polyphenols have revealed their role as cardioprotective agents. However, an obvious shortage of in vivo studies related to dose selection and toxicity of polyphenols makes these compounds a suitable target for clinical investigations. Further studies are needed for the development of safe and potent herbal products against cardiovascular diseases. The novelty of this review is to provide comprehensive knowledge on polyphenols safety and their health claims. It will help researchers to identify those moieties which likely exert protective and therapeutic effects towards cardiovascular diseases.Keywords: cardiovascular diseases, polyphenols, clinical trials, cardioprotective, antioxidantAlotaibi BSIjaz MBuabeid MKharaba ZJYaseen HSMurtaza GDove Medical Pressarticlecardiovascular diseasespolyphenolsclinical trialscardioprotectiveantioxidantTherapeutics. PharmacologyRM1-950ENDrug Design, Development and Therapy, Vol Volume 15, Pp 4713-4732 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cardiovascular diseases polyphenols clinical trials cardioprotective antioxidant Therapeutics. Pharmacology RM1-950
spellingShingle	cardiovascular diseases polyphenols clinical trials cardioprotective antioxidant Therapeutics. Pharmacology RM1-950 Alotaibi BS Ijaz M Buabeid M Kharaba ZJ Yaseen HS Murtaza G Therapeutic Effects and Safe Uses of Plant-Derived Polyphenolic Compounds in Cardiovascular Diseases: A Review
description	Badriyah Shadid Alotaibi,1 Munazza Ijaz,2 Manal Buabeid,3,4 Zelal Jaber Kharaba,5 Hafiza Sidra Yaseen,6 Ghulam Murtaza6 1Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia; 2Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan; 3Medical and Bio-Allied Health Sciences Research Centre, Ajman University, Ajman, United Arab Emirates; 4Department of Clinical Sciences, Ajman University, Ajman, 346, United Arab Emirates; 5Department of Clinical Sciences, College of Pharmacy, Al-Ain University of Science and Technology, Abu Dhabi, United Arab Emirates; 6Department of Pharmacy, COMSATS University Islamabad, Lahore Campus, Lahore, 54000, PakistanCorrespondence: Manal Buabeid; Ghulam Murtaza Tel +92 3215129950Fax +92 992-383441Email m.buabeid@ajman.ac.ae; gmdogar356@gmail.comAbstract: Polyphenols have long been recognized as health-promoting entities, including beneficial effects on cardiovascular disease, but their reputation has been boosted recently following a number of encouraging clinical studies in multiple chronic pathologies, that seem to validate efficacy. Health benefits of polyphenols have been linked to their well-established powerful antioxidant activity. This review aims to provide comprehensive and up-to-date knowledge on the current therapeutic status of polyphenols having sufficient heed towards the treatment of cardiovascular diseases. Furthermore, data about the safety profile of highly efficacious polyphenols has also been investigated to further enhance their role in cardiac abnormalities. Evidence is presented to support the action of phenolic derivatives against cardiovascular pathologies by following receptors and signaling pathways which ultimately cause changes in endogenous antioxidant, antiplatelet, vasodilatory, and anti-inflammatory activities. In addition, in vitro antioxidant and pre-clinical and clinical experiments on anti-inflammatory as well as immunomodulatory attributes of polyphenols have revealed their role as cardioprotective agents. However, an obvious shortage of in vivo studies related to dose selection and toxicity of polyphenols makes these compounds a suitable target for clinical investigations. Further studies are needed for the development of safe and potent herbal products against cardiovascular diseases. The novelty of this review is to provide comprehensive knowledge on polyphenols safety and their health claims. It will help researchers to identify those moieties which likely exert protective and therapeutic effects towards cardiovascular diseases.Keywords: cardiovascular diseases, polyphenols, clinical trials, cardioprotective, antioxidant
format	article
author	Alotaibi BS Ijaz M Buabeid M Kharaba ZJ Yaseen HS Murtaza G
author_facet	Alotaibi BS Ijaz M Buabeid M Kharaba ZJ Yaseen HS Murtaza G
author_sort	Alotaibi BS
title	Therapeutic Effects and Safe Uses of Plant-Derived Polyphenolic Compounds in Cardiovascular Diseases: A Review
title_short	Therapeutic Effects and Safe Uses of Plant-Derived Polyphenolic Compounds in Cardiovascular Diseases: A Review
title_full	Therapeutic Effects and Safe Uses of Plant-Derived Polyphenolic Compounds in Cardiovascular Diseases: A Review
title_fullStr	Therapeutic Effects and Safe Uses of Plant-Derived Polyphenolic Compounds in Cardiovascular Diseases: A Review
title_full_unstemmed	Therapeutic Effects and Safe Uses of Plant-Derived Polyphenolic Compounds in Cardiovascular Diseases: A Review
title_sort	therapeutic effects and safe uses of plant-derived polyphenolic compounds in cardiovascular diseases: a review
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/844674c3a6b44f0dadbabe38ca42cd1b
work_keys_str_mv	AT alotaibibs therapeuticeffectsandsafeusesofplantderivedpolyphenoliccompoundsincardiovasculardiseasesareview AT ijazm therapeuticeffectsandsafeusesofplantderivedpolyphenoliccompoundsincardiovasculardiseasesareview AT buabeidm therapeuticeffectsandsafeusesofplantderivedpolyphenoliccompoundsincardiovasculardiseasesareview AT kharabazj therapeuticeffectsandsafeusesofplantderivedpolyphenoliccompoundsincardiovasculardiseasesareview AT yaseenhs therapeuticeffectsandsafeusesofplantderivedpolyphenoliccompoundsincardiovasculardiseasesareview AT murtazag therapeuticeffectsandsafeusesofplantderivedpolyphenoliccompoundsincardiovasculardiseasesareview
_version_	1718418711270916096

Therapeutic Effects and Safe Uses of Plant-Derived Polyphenolic Compounds in Cardiovascular Diseases: A Review

Ejemplares similares