The cognitive effects of a promised bonus do not depend on dopamine synthesis capacity

Abstract Reward motivation is known to enhance cognitive control. However, detrimental effects have also been observed, which have been attributed to overdosing of already high baseline dopamine levels by further dopamine increases elicited by reward cues. Aarts et al. (2014) indeed demonstrated, in...

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Autores principales:	Lieke Hofmans, Ruben van den Bosch, Jessica I. Määttä, Robbert-Jan Verkes, Esther Aarts, Roshan Cools
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/84478ea534cb4ceda7743298b93dae7e
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spelling	oai:doaj.org-article:84478ea534cb4ceda7743298b93dae7e2021-12-02T18:37:07ZThe cognitive effects of a promised bonus do not depend on dopamine synthesis capacity10.1038/s41598-020-72329-42045-2322https://doaj.org/article/84478ea534cb4ceda7743298b93dae7e2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-72329-4https://doaj.org/toc/2045-2322Abstract Reward motivation is known to enhance cognitive control. However, detrimental effects have also been observed, which have been attributed to overdosing of already high baseline dopamine levels by further dopamine increases elicited by reward cues. Aarts et al. (2014) indeed demonstrated, in 14 individuals, that reward effects depended on striatal dopamine synthesis capacity, measured with [18F]FMT-PET: promised reward improved Stroop control in low-dopamine individuals, while impairing it in high-dopamine individuals. Here, we aimed to assess this same effect in 44 new participants, who had previously undergone an [18F]DOPA-PET scan to quantify dopamine synthesis capacity. This sample performed the exact same rewarded Stroop paradigm as in the prior study. However, we did not find any correlation between reward effects on cognitive control and striatal dopamine synthesis capacity. Critical differences between the radiotracers [18F]DOPA and [18F]FMT are discussed, as the discrepancy between the current and our previous findings might reflect the use of the potentially less sensitive [18F]DOPA radiotracer in the current study.Lieke HofmansRuben van den BoschJessica I. MäättäRobbert-Jan VerkesEsther AartsRoshan CoolsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lieke Hofmans Ruben van den Bosch Jessica I. Määttä Robbert-Jan Verkes Esther Aarts Roshan Cools The cognitive effects of a promised bonus do not depend on dopamine synthesis capacity
description	Abstract Reward motivation is known to enhance cognitive control. However, detrimental effects have also been observed, which have been attributed to overdosing of already high baseline dopamine levels by further dopamine increases elicited by reward cues. Aarts et al. (2014) indeed demonstrated, in 14 individuals, that reward effects depended on striatal dopamine synthesis capacity, measured with [18F]FMT-PET: promised reward improved Stroop control in low-dopamine individuals, while impairing it in high-dopamine individuals. Here, we aimed to assess this same effect in 44 new participants, who had previously undergone an [18F]DOPA-PET scan to quantify dopamine synthesis capacity. This sample performed the exact same rewarded Stroop paradigm as in the prior study. However, we did not find any correlation between reward effects on cognitive control and striatal dopamine synthesis capacity. Critical differences between the radiotracers [18F]DOPA and [18F]FMT are discussed, as the discrepancy between the current and our previous findings might reflect the use of the potentially less sensitive [18F]DOPA radiotracer in the current study.
format	article
author	Lieke Hofmans Ruben van den Bosch Jessica I. Määttä Robbert-Jan Verkes Esther Aarts Roshan Cools
author_facet	Lieke Hofmans Ruben van den Bosch Jessica I. Määttä Robbert-Jan Verkes Esther Aarts Roshan Cools
author_sort	Lieke Hofmans
title	The cognitive effects of a promised bonus do not depend on dopamine synthesis capacity
title_short	The cognitive effects of a promised bonus do not depend on dopamine synthesis capacity
title_full	The cognitive effects of a promised bonus do not depend on dopamine synthesis capacity
title_fullStr	The cognitive effects of a promised bonus do not depend on dopamine synthesis capacity
title_full_unstemmed	The cognitive effects of a promised bonus do not depend on dopamine synthesis capacity
title_sort	cognitive effects of a promised bonus do not depend on dopamine synthesis capacity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/84478ea534cb4ceda7743298b93dae7e
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The cognitive effects of a promised bonus do not depend on dopamine synthesis capacity

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