Cingulin and actin mediate midbody-dependent apical lumen formation during polarization of epithelial cells

Polarisation of epithelial cells causes lumen formation, which is mediated by apical membrane initiation site (AMIS) and FIP5, but how this is regulated is unclear. Here, the authors identify cingulin as a FIP-5 interacting protein, recruiting the Rac1-WAVE/Scar complex to the AMIS and branched acti...

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Autores principales:	Anthony J. Mangan, Daniel V. Sietsema, Dongying Li, Jeffrey K. Moore, Sandra Citi, Rytis Prekeris
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/845014529cdd4857ab83d3e6c1694918
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spelling	oai:doaj.org-article:845014529cdd4857ab83d3e6c16949182021-12-02T17:31:50ZCingulin and actin mediate midbody-dependent apical lumen formation during polarization of epithelial cells10.1038/ncomms124262041-1723https://doaj.org/article/845014529cdd4857ab83d3e6c16949182016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12426https://doaj.org/toc/2041-1723Polarisation of epithelial cells causes lumen formation, which is mediated by apical membrane initiation site (AMIS) and FIP5, but how this is regulated is unclear. Here, the authors identify cingulin as a FIP-5 interacting protein, recruiting the Rac1-WAVE/Scar complex to the AMIS and branched actin formation.Anthony J. ManganDaniel V. SietsemaDongying LiJeffrey K. MooreSandra CitiRytis PrekerisNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anthony J. Mangan Daniel V. Sietsema Dongying Li Jeffrey K. Moore Sandra Citi Rytis Prekeris Cingulin and actin mediate midbody-dependent apical lumen formation during polarization of epithelial cells
description	Polarisation of epithelial cells causes lumen formation, which is mediated by apical membrane initiation site (AMIS) and FIP5, but how this is regulated is unclear. Here, the authors identify cingulin as a FIP-5 interacting protein, recruiting the Rac1-WAVE/Scar complex to the AMIS and branched actin formation.
format	article
author	Anthony J. Mangan Daniel V. Sietsema Dongying Li Jeffrey K. Moore Sandra Citi Rytis Prekeris
author_facet	Anthony J. Mangan Daniel V. Sietsema Dongying Li Jeffrey K. Moore Sandra Citi Rytis Prekeris
author_sort	Anthony J. Mangan
title	Cingulin and actin mediate midbody-dependent apical lumen formation during polarization of epithelial cells
title_short	Cingulin and actin mediate midbody-dependent apical lumen formation during polarization of epithelial cells
title_full	Cingulin and actin mediate midbody-dependent apical lumen formation during polarization of epithelial cells
title_fullStr	Cingulin and actin mediate midbody-dependent apical lumen formation during polarization of epithelial cells
title_full_unstemmed	Cingulin and actin mediate midbody-dependent apical lumen formation during polarization of epithelial cells
title_sort	cingulin and actin mediate midbody-dependent apical lumen formation during polarization of epithelial cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/845014529cdd4857ab83d3e6c1694918
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Cingulin and actin mediate midbody-dependent apical lumen formation during polarization of epithelial cells

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