Cingulin and actin mediate midbody-dependent apical lumen formation during polarization of epithelial cells

Cingulin and actin mediate midbody-dependent apical lumen formation during polarization of epithelial cells

Polarisation of epithelial cells causes lumen formation, which is mediated by apical membrane initiation site (AMIS) and FIP5, but how this is regulated is unclear. Here, the authors identify cingulin as a FIP-5 interacting protein, recruiting the Rac1-WAVE/Scar complex to the AMIS and branched acti...

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Autores principales: Anthony J. Mangan, Daniel V. Sietsema, Dongying Li, Jeffrey K. Moore, Sandra Citi, Rytis Prekeris
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/845014529cdd4857ab83d3e6c1694918
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