Combined cell and nanoparticle models for TOPAS to study radiation dose enhancement in cell organelles

Abstract Dose enhancement by gold nanoparticles (AuNP) increases the biological effectiveness of radiation damage in biomolecules and tissue. To apply them effectively during cancer therapy their influence on the locally delivered dose has to be determined. Hereby, the AuNP locations strongly influe...

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Autores principales:	Marc Benjamin Hahn, Julián Mateo Zutta Villate
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/845087c4ff2344a4bae44ff5a1c6ffd0
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spelling	oai:doaj.org-article:845087c4ff2344a4bae44ff5a1c6ffd02021-12-02T13:24:26ZCombined cell and nanoparticle models for TOPAS to study radiation dose enhancement in cell organelles10.1038/s41598-021-85964-22045-2322https://doaj.org/article/845087c4ff2344a4bae44ff5a1c6ffd02021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85964-2https://doaj.org/toc/2045-2322Abstract Dose enhancement by gold nanoparticles (AuNP) increases the biological effectiveness of radiation damage in biomolecules and tissue. To apply them effectively during cancer therapy their influence on the locally delivered dose has to be determined. Hereby, the AuNP locations strongly influence the energy deposit in the nucleus, mitochondria, membrane and the cytosol of the targeted cells. To estimate these effects, particle scattering simulations are applied. In general, different approaches for modeling the AuNP and their distribution within the cell are possible. In this work, two newly developed continuous and discrete-geometric models for simulations of AuNP in cells are presented. These models are applicable to simulations of internal emitters and external radiation sources. Most of the current studies on AuNP focus on external beam therapy. In contrast, we apply the presented models in Monte-Carlo particle scattering simulations to characterize the energy deposit in cell organelles by radioactive 198AuNP. They emit beta and gamma rays and are therefore considered for applications with solid tumors. Differences in local dose enhancement between randomly distributed and nucleus targeted nanoparticles are compared. Hereby nucleus targeted nanoparticels showed a strong local dose enhancement in the radio sensitive nucleus. These results are the foundation for future experimental work which aims to obtain a mechanistic understanding of cell death induced by radioactive 198Au.Marc Benjamin HahnJulián Mateo Zutta VillateNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marc Benjamin Hahn Julián Mateo Zutta Villate Combined cell and nanoparticle models for TOPAS to study radiation dose enhancement in cell organelles
description	Abstract Dose enhancement by gold nanoparticles (AuNP) increases the biological effectiveness of radiation damage in biomolecules and tissue. To apply them effectively during cancer therapy their influence on the locally delivered dose has to be determined. Hereby, the AuNP locations strongly influence the energy deposit in the nucleus, mitochondria, membrane and the cytosol of the targeted cells. To estimate these effects, particle scattering simulations are applied. In general, different approaches for modeling the AuNP and their distribution within the cell are possible. In this work, two newly developed continuous and discrete-geometric models for simulations of AuNP in cells are presented. These models are applicable to simulations of internal emitters and external radiation sources. Most of the current studies on AuNP focus on external beam therapy. In contrast, we apply the presented models in Monte-Carlo particle scattering simulations to characterize the energy deposit in cell organelles by radioactive 198AuNP. They emit beta and gamma rays and are therefore considered for applications with solid tumors. Differences in local dose enhancement between randomly distributed and nucleus targeted nanoparticles are compared. Hereby nucleus targeted nanoparticels showed a strong local dose enhancement in the radio sensitive nucleus. These results are the foundation for future experimental work which aims to obtain a mechanistic understanding of cell death induced by radioactive 198Au.
format	article
author	Marc Benjamin Hahn Julián Mateo Zutta Villate
author_facet	Marc Benjamin Hahn Julián Mateo Zutta Villate
author_sort	Marc Benjamin Hahn
title	Combined cell and nanoparticle models for TOPAS to study radiation dose enhancement in cell organelles
title_short	Combined cell and nanoparticle models for TOPAS to study radiation dose enhancement in cell organelles
title_full	Combined cell and nanoparticle models for TOPAS to study radiation dose enhancement in cell organelles
title_fullStr	Combined cell and nanoparticle models for TOPAS to study radiation dose enhancement in cell organelles
title_full_unstemmed	Combined cell and nanoparticle models for TOPAS to study radiation dose enhancement in cell organelles
title_sort	combined cell and nanoparticle models for topas to study radiation dose enhancement in cell organelles
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/845087c4ff2344a4bae44ff5a1c6ffd0
work_keys_str_mv	AT marcbenjaminhahn combinedcellandnanoparticlemodelsfortopastostudyradiationdoseenhancementincellorganelles AT julianmateozuttavillate combinedcellandnanoparticlemodelsfortopastostudyradiationdoseenhancementincellorganelles
_version_	1718393105507418112

Combined cell and nanoparticle models for TOPAS to study radiation dose enhancement in cell organelles

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