Mesomelic dysplasias associated with the HOXD locus are caused by regulatory reallocations

Mesomelic dysplasia, a severe shortening and bending of the limb, has been linked to rearrangements in the HoxD cluster in humans and mice. Here the authors engineer a 1 Mb inversion including the HoxD gene cluster and use this model to provide a mechanistic framework to understand and unify the mol...

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Autores principales:	Christopher Chase Bolt, Lucille Lopez-Delisle, Bénédicte Mascrez, Denis Duboule
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/845162fb54f74e788eb7f21c33002bfc
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spelling	oai:doaj.org-article:845162fb54f74e788eb7f21c33002bfc2021-12-02T15:10:55ZMesomelic dysplasias associated with the HOXD locus are caused by regulatory reallocations10.1038/s41467-021-25330-y2041-1723https://doaj.org/article/845162fb54f74e788eb7f21c33002bfc2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25330-yhttps://doaj.org/toc/2041-1723Mesomelic dysplasia, a severe shortening and bending of the limb, has been linked to rearrangements in the HoxD cluster in humans and mice. Here the authors engineer a 1 Mb inversion including the HoxD gene cluster and use this model to provide a mechanistic framework to understand and unify the molecular origins of human mesomelic dysplasia associated with 2q31.Christopher Chase BoltLucille Lopez-DelisleBénédicte MascrezDenis DubouleNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christopher Chase Bolt Lucille Lopez-Delisle Bénédicte Mascrez Denis Duboule Mesomelic dysplasias associated with the HOXD locus are caused by regulatory reallocations
description	Mesomelic dysplasia, a severe shortening and bending of the limb, has been linked to rearrangements in the HoxD cluster in humans and mice. Here the authors engineer a 1 Mb inversion including the HoxD gene cluster and use this model to provide a mechanistic framework to understand and unify the molecular origins of human mesomelic dysplasia associated with 2q31.
format	article
author	Christopher Chase Bolt Lucille Lopez-Delisle Bénédicte Mascrez Denis Duboule
author_facet	Christopher Chase Bolt Lucille Lopez-Delisle Bénédicte Mascrez Denis Duboule
author_sort	Christopher Chase Bolt
title	Mesomelic dysplasias associated with the HOXD locus are caused by regulatory reallocations
title_short	Mesomelic dysplasias associated with the HOXD locus are caused by regulatory reallocations
title_full	Mesomelic dysplasias associated with the HOXD locus are caused by regulatory reallocations
title_fullStr	Mesomelic dysplasias associated with the HOXD locus are caused by regulatory reallocations
title_full_unstemmed	Mesomelic dysplasias associated with the HOXD locus are caused by regulatory reallocations
title_sort	mesomelic dysplasias associated with the hoxd locus are caused by regulatory reallocations
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/845162fb54f74e788eb7f21c33002bfc
work_keys_str_mv	AT christopherchasebolt mesomelicdysplasiasassociatedwiththehoxdlocusarecausedbyregulatoryreallocations AT lucillelopezdelisle mesomelicdysplasiasassociatedwiththehoxdlocusarecausedbyregulatoryreallocations AT benedictemascrez mesomelicdysplasiasassociatedwiththehoxdlocusarecausedbyregulatoryreallocations AT denisduboule mesomelicdysplasiasassociatedwiththehoxdlocusarecausedbyregulatoryreallocations
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Mesomelic dysplasias associated with the HOXD locus are caused by regulatory reallocations

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