A Gly98Val mutation in the N-Myc downstream regulated gene 1 (NDRG1) in Alaskan Malamutes with polyneuropathy.

A Gly98Val mutation in the N-Myc downstream regulated gene 1 (NDRG1) in Alaskan Malamutes with polyneuropathy.

The first cases of early-onset progressive polyneuropathy appeared in the Alaskan Malamute population in Norway in the late 1970s. Affected dogs were of both sexes and were ambulatory paraparetic, progressing to non-ambulatory tetraparesis. On neurologic examination, affected dogs displayed predomin...

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Autores principales: Camilla S Bruun, Karin H Jäderlund, Mette Berendt, Kristine B Jensen, Eva H Spodsberg, Hanne Gredal, G Diane Shelton, James R Mickelson, Katie M Minor, Hannes Lohi, Inge Bjerkås, Oyvind Stigen, Arild Espenes, Cecilia Rohdin, Rebecca Edlund, Jennie Ohlsson, Sigitas Cizinauskas, Páll S Leifsson, Cord Drögemüller, Lars Moe, Susanna Cirera, Merete Fredholm
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/8455050285dc4931a8f4584a8dc8e995
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