Schistosoma mansoni infection risk for school-aged children clusters within households and is modified by distance to freshwater bodies.

<h4>Background</h4>The interaction of socio-demographic and ecological factors with Schistosoma mansoni (S. mansoni) infection risk by age and the household clustering of infections between individuals are poorly understood.<h4>Methods</h4>This study examined 1,832 individual...

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Autores principales:	Olimpia Lamberti, Narcis B Kabatereine, Edridah M Tukahebwa, Goylette F Chami
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8456fb923a664dd498e395fea06cca20
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spelling	oai:doaj.org-article:8456fb923a664dd498e395fea06cca202021-12-02T20:04:22ZSchistosoma mansoni infection risk for school-aged children clusters within households and is modified by distance to freshwater bodies.1932-620310.1371/journal.pone.0258915https://doaj.org/article/8456fb923a664dd498e395fea06cca202021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258915https://doaj.org/toc/1932-6203<h4>Background</h4>The interaction of socio-demographic and ecological factors with Schistosoma mansoni (S. mansoni) infection risk by age and the household clustering of infections between individuals are poorly understood.<h4>Methods</h4>This study examined 1,832 individuals aged 5-90 years across 916 households in Mayuge District, Uganda. S. mansoni infection status and intensity were measured using Kato-Katz microscopy. Socio-demographic and ecological factors were examined as predictors of infection status and intensity using logistic and negative binomial regression models, respectively, with standard errors clustered by household. A subgroup analysis of children was conducted to examine the correlation of infection status between children and their caretakers.<h4>Findings</h4>Infection varied within age groups based on the distance to Lake Victoria. Children aged 9-17 years and young adults aged 18-29 years who lived ≤0.50km from Lake Victoria were more likely to be infected compared to individuals of the same age who lived further away from the lake. Infections clustered within households. Children whose caretakers were heavily infected were 2.67 times more likely to be infected.<h4>Conclusion</h4>These findings demonstrate the focality of schistosome transmission and its dependence on socio-demographic, ecological and household factors. Future research should investigate the sampling of households within communities as a means of progressing towards precision mapping of S. mansoni infections.Olimpia LambertiNarcis B KabatereineEdridah M TukahebwaGoylette F ChamiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0258915 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Olimpia Lamberti Narcis B Kabatereine Edridah M Tukahebwa Goylette F Chami Schistosoma mansoni infection risk for school-aged children clusters within households and is modified by distance to freshwater bodies.
description	<h4>Background</h4>The interaction of socio-demographic and ecological factors with Schistosoma mansoni (S. mansoni) infection risk by age and the household clustering of infections between individuals are poorly understood.<h4>Methods</h4>This study examined 1,832 individuals aged 5-90 years across 916 households in Mayuge District, Uganda. S. mansoni infection status and intensity were measured using Kato-Katz microscopy. Socio-demographic and ecological factors were examined as predictors of infection status and intensity using logistic and negative binomial regression models, respectively, with standard errors clustered by household. A subgroup analysis of children was conducted to examine the correlation of infection status between children and their caretakers.<h4>Findings</h4>Infection varied within age groups based on the distance to Lake Victoria. Children aged 9-17 years and young adults aged 18-29 years who lived ≤0.50km from Lake Victoria were more likely to be infected compared to individuals of the same age who lived further away from the lake. Infections clustered within households. Children whose caretakers were heavily infected were 2.67 times more likely to be infected.<h4>Conclusion</h4>These findings demonstrate the focality of schistosome transmission and its dependence on socio-demographic, ecological and household factors. Future research should investigate the sampling of households within communities as a means of progressing towards precision mapping of S. mansoni infections.
format	article
author	Olimpia Lamberti Narcis B Kabatereine Edridah M Tukahebwa Goylette F Chami
author_facet	Olimpia Lamberti Narcis B Kabatereine Edridah M Tukahebwa Goylette F Chami
author_sort	Olimpia Lamberti
title	Schistosoma mansoni infection risk for school-aged children clusters within households and is modified by distance to freshwater bodies.
title_short	Schistosoma mansoni infection risk for school-aged children clusters within households and is modified by distance to freshwater bodies.
title_full	Schistosoma mansoni infection risk for school-aged children clusters within households and is modified by distance to freshwater bodies.
title_fullStr	Schistosoma mansoni infection risk for school-aged children clusters within households and is modified by distance to freshwater bodies.
title_full_unstemmed	Schistosoma mansoni infection risk for school-aged children clusters within households and is modified by distance to freshwater bodies.
title_sort	schistosoma mansoni infection risk for school-aged children clusters within households and is modified by distance to freshwater bodies.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/8456fb923a664dd498e395fea06cca20
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Schistosoma mansoni infection risk for school-aged children clusters within households and is modified by distance to freshwater bodies.

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