DETECTION OF MODIFIED LIPOPROTEINS IN ATHEROSCLEROTIC LESIONS OF HUMAN AORTA

Abstract. Specific autoantibodies against acetylated, maleylated and malonic dialdehyde-(MDA)-modified lipoproteins are detectable in human plasma. Immunization of rabbits with autologous, correspondingly modified low-density lipoproteins (LDLs) did induce autoantibodies against acetylated, maleylat...

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Autores principales:	P. V. Pigarevsky, O. Yu. Archipova, A. D. Denisenko
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	autoantibodies modified lipoproteins vascular wall immunohistochemistry Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/8457e47fce0645afa5106cdf27aa3bef
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spelling	oai:doaj.org-article:8457e47fce0645afa5106cdf27aa3bef2021-11-18T08:03:42ZDETECTION OF MODIFIED LIPOPROTEINS IN ATHEROSCLEROTIC LESIONS OF HUMAN AORTA1563-06252313-741X10.15789/1563-0625-2006-5-6-637-644https://doaj.org/article/8457e47fce0645afa5106cdf27aa3bef2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/537https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Specific autoantibodies against acetylated, maleylated and malonic dialdehyde-(MDA)-modified lipoproteins are detectable in human plasma. Immunization of rabbits with autologous, correspondingly modified low-density lipoproteins (LDLs) did induce autoantibodies against acetylated, maleylated and MDA-modified lipoproteins. In atherosclerotic lesions from hyman aorta, the epitopes have been detected that were recognized by the antibodies to acetylated, maleylated, and MDA-modified LDLs. Such antigens were detected at all atherogenesis stages, beginning with the earliest lesions (lipid spots), and their deposition pattern was quite variable.Rabbit and human autoantibodies against acetylated, maleylated and MDA-modified lipoproteins recognized antigens in human atherosclerotic aorta. Modified proteins were localized both intra- and extracellular in tectum, superficial and deep layers of the atherosclerotic lesions. The most typical mode of depositions for all modified proteins si represented by extracellular deposits in the cap of lipid streaks and fibrous plaques, especially in transitional “shoulder” area.The intimal deposits of modified proteins shared similar features with distribution of apo-B-containing lipoproteins, like as of lipids detectable by Oil Red staining. The areas where modified proteins and apo-B-containing lipoproteins were revealed did often coincide with foci of IgG deposits. Modified proteins were not detectable in the non-affected segments of aortic intima.P. V. PigarevskyO. Yu. ArchipovaA. D. DenisenkoSPb RAACIarticleautoantibodiesmodified lipoproteinsvascular wallimmunohistochemistryImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 8, Iss 5-6, Pp 637-644 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	autoantibodies modified lipoproteins vascular wall immunohistochemistry Immunologic diseases. Allergy RC581-607
spellingShingle	autoantibodies modified lipoproteins vascular wall immunohistochemistry Immunologic diseases. Allergy RC581-607 P. V. Pigarevsky O. Yu. Archipova A. D. Denisenko DETECTION OF MODIFIED LIPOPROTEINS IN ATHEROSCLEROTIC LESIONS OF HUMAN AORTA
description	Abstract. Specific autoantibodies against acetylated, maleylated and malonic dialdehyde-(MDA)-modified lipoproteins are detectable in human plasma. Immunization of rabbits with autologous, correspondingly modified low-density lipoproteins (LDLs) did induce autoantibodies against acetylated, maleylated and MDA-modified lipoproteins. In atherosclerotic lesions from hyman aorta, the epitopes have been detected that were recognized by the antibodies to acetylated, maleylated, and MDA-modified LDLs. Such antigens were detected at all atherogenesis stages, beginning with the earliest lesions (lipid spots), and their deposition pattern was quite variable.Rabbit and human autoantibodies against acetylated, maleylated and MDA-modified lipoproteins recognized antigens in human atherosclerotic aorta. Modified proteins were localized both intra- and extracellular in tectum, superficial and deep layers of the atherosclerotic lesions. The most typical mode of depositions for all modified proteins si represented by extracellular deposits in the cap of lipid streaks and fibrous plaques, especially in transitional “shoulder” area.The intimal deposits of modified proteins shared similar features with distribution of apo-B-containing lipoproteins, like as of lipids detectable by Oil Red staining. The areas where modified proteins and apo-B-containing lipoproteins were revealed did often coincide with foci of IgG deposits. Modified proteins were not detectable in the non-affected segments of aortic intima.
format	article
author	P. V. Pigarevsky O. Yu. Archipova A. D. Denisenko
author_facet	P. V. Pigarevsky O. Yu. Archipova A. D. Denisenko
author_sort	P. V. Pigarevsky
title	DETECTION OF MODIFIED LIPOPROTEINS IN ATHEROSCLEROTIC LESIONS OF HUMAN AORTA
title_short	DETECTION OF MODIFIED LIPOPROTEINS IN ATHEROSCLEROTIC LESIONS OF HUMAN AORTA
title_full	DETECTION OF MODIFIED LIPOPROTEINS IN ATHEROSCLEROTIC LESIONS OF HUMAN AORTA
title_fullStr	DETECTION OF MODIFIED LIPOPROTEINS IN ATHEROSCLEROTIC LESIONS OF HUMAN AORTA
title_full_unstemmed	DETECTION OF MODIFIED LIPOPROTEINS IN ATHEROSCLEROTIC LESIONS OF HUMAN AORTA
title_sort	detection of modified lipoproteins in atherosclerotic lesions of human aorta
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/8457e47fce0645afa5106cdf27aa3bef
work_keys_str_mv	AT pvpigarevsky detectionofmodifiedlipoproteinsinatheroscleroticlesionsofhumanaorta AT oyuarchipova detectionofmodifiedlipoproteinsinatheroscleroticlesionsofhumanaorta AT addenisenko detectionofmodifiedlipoproteinsinatheroscleroticlesionsofhumanaorta
_version_	1718422489109889024

DETECTION OF MODIFIED LIPOPROTEINS IN ATHEROSCLEROTIC LESIONS OF HUMAN AORTA

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