Silencing of the lncRNA Zeb2-NAT facilitates reprogramming of aged fibroblasts and safeguards stem cell pluripotency

The efficiency of somatic cell reprogramming is lowered by ageing. Here the authors show that the transcription factor Zeb2 and its long non-coding RNA Zeb2-NAT are expressed at high levels in older fibroblasts and their inhibition increases reprogramming efficiency.

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Autores principales:	Bruno Bernardes de Jesus, Sérgio Pires Marinho, Sara Barros, António Sousa-Franco, Catarina Alves-Vale, Tânia Carvalho, Maria Carmo-Fonseca
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/845a0aaa64034064ba933f5241de3688
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spelling	oai:doaj.org-article:845a0aaa64034064ba933f5241de36882021-12-02T15:34:23ZSilencing of the lncRNA Zeb2-NAT facilitates reprogramming of aged fibroblasts and safeguards stem cell pluripotency10.1038/s41467-017-01921-62041-1723https://doaj.org/article/845a0aaa64034064ba933f5241de36882018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01921-6https://doaj.org/toc/2041-1723The efficiency of somatic cell reprogramming is lowered by ageing. Here the authors show that the transcription factor Zeb2 and its long non-coding RNA Zeb2-NAT are expressed at high levels in older fibroblasts and their inhibition increases reprogramming efficiency.Bruno Bernardes de JesusSérgio Pires MarinhoSara BarrosAntónio Sousa-FrancoCatarina Alves-ValeTânia CarvalhoMaria Carmo-FonsecaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bruno Bernardes de Jesus Sérgio Pires Marinho Sara Barros António Sousa-Franco Catarina Alves-Vale Tânia Carvalho Maria Carmo-Fonseca Silencing of the lncRNA Zeb2-NAT facilitates reprogramming of aged fibroblasts and safeguards stem cell pluripotency
description	The efficiency of somatic cell reprogramming is lowered by ageing. Here the authors show that the transcription factor Zeb2 and its long non-coding RNA Zeb2-NAT are expressed at high levels in older fibroblasts and their inhibition increases reprogramming efficiency.
format	article
author	Bruno Bernardes de Jesus Sérgio Pires Marinho Sara Barros António Sousa-Franco Catarina Alves-Vale Tânia Carvalho Maria Carmo-Fonseca
author_facet	Bruno Bernardes de Jesus Sérgio Pires Marinho Sara Barros António Sousa-Franco Catarina Alves-Vale Tânia Carvalho Maria Carmo-Fonseca
author_sort	Bruno Bernardes de Jesus
title	Silencing of the lncRNA Zeb2-NAT facilitates reprogramming of aged fibroblasts and safeguards stem cell pluripotency
title_short	Silencing of the lncRNA Zeb2-NAT facilitates reprogramming of aged fibroblasts and safeguards stem cell pluripotency
title_full	Silencing of the lncRNA Zeb2-NAT facilitates reprogramming of aged fibroblasts and safeguards stem cell pluripotency
title_fullStr	Silencing of the lncRNA Zeb2-NAT facilitates reprogramming of aged fibroblasts and safeguards stem cell pluripotency
title_full_unstemmed	Silencing of the lncRNA Zeb2-NAT facilitates reprogramming of aged fibroblasts and safeguards stem cell pluripotency
title_sort	silencing of the lncrna zeb2-nat facilitates reprogramming of aged fibroblasts and safeguards stem cell pluripotency
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/845a0aaa64034064ba933f5241de3688
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Silencing of the lncRNA Zeb2-NAT facilitates reprogramming of aged fibroblasts and safeguards stem cell pluripotency

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