Homocysteine is associated with plasma high-sensitivity cardiac troponin T levels in a community-dwelling population

Ruihua Cao,* Yongyi Bai,* Ruyi Xu, Ping YeDepartment of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People's Republic of China*These authors contributed equally to this workObjectives: Homocysteine (HCY) is associated with an increased risk for cardiovascular disease, possib...

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Autores principales:	Cao R, Bai Y, Xu R, Ye P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Homocysteine High-sensitivity cardiac troponin T Epidemiology Myocardial damage Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/845cc964c0fd430a91ea20762020b630
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spelling	oai:doaj.org-article:845cc964c0fd430a91ea20762020b6302021-12-02T02:05:20ZHomocysteine is associated with plasma high-sensitivity cardiac troponin T levels in a community-dwelling population1178-1998https://doaj.org/article/845cc964c0fd430a91ea20762020b6302013-12-01T00:00:00Zhttps://www.dovepress.com/homocysteine-is-associated-with-plasma-high-sensitivity-cardiac-tropon-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Ruihua Cao,* Yongyi Bai,* Ruyi Xu, Ping YeDepartment of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People's Republic of China*These authors contributed equally to this workObjectives: Homocysteine (HCY) is associated with an increased risk for cardiovascular disease, possibly leading to myocardial damage. Cardiac troponin T (TnT), a marker of cardiomyocyte injury, can be detected by high-sensitivity TnT (hsTnT) assay. The current study investigated the relationship between plasma HCY and hsTnT levels in a community-based population.Methods: We related plasma levels of hsTnT to HCY levels in 1,497 participants (mean age, 62.4 years; 629 men, 868 women) from a community-based population in Beijing, People's Republic of China.Results: In multiple logistic regression models, serum HCY was associated with a higher likelihood of detectable hsTnT (odds ratio 1.5; 95% confidence interval 1.07–2.10; P=0.018). A subsequent subgroup analysis found that in subjects aged 65 years and older, the association between hsTnT levels and HCY levels was strengthened. The association between hsTnT and HCY was not present in the younger subgroup (<65 years old).Conclusion: Levels of serum HCY are associated with hsTnT levels in the elderly, indicating a relationship between HCY and subclinical myocardial damage.Keywords: epidemiology, myocardial damage, markers, relationship, subclinicalCao RBai YXu RYe PDove Medical PressarticleHomocysteineHigh-sensitivity cardiac troponin TEpidemiologyMyocardial damageGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 9, Pp 79-84 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Homocysteine High-sensitivity cardiac troponin T Epidemiology Myocardial damage Geriatrics RC952-954.6
spellingShingle	Homocysteine High-sensitivity cardiac troponin T Epidemiology Myocardial damage Geriatrics RC952-954.6 Cao R Bai Y Xu R Ye P Homocysteine is associated with plasma high-sensitivity cardiac troponin T levels in a community-dwelling population
description	Ruihua Cao,* Yongyi Bai,* Ruyi Xu, Ping YeDepartment of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People's Republic of China*These authors contributed equally to this workObjectives: Homocysteine (HCY) is associated with an increased risk for cardiovascular disease, possibly leading to myocardial damage. Cardiac troponin T (TnT), a marker of cardiomyocyte injury, can be detected by high-sensitivity TnT (hsTnT) assay. The current study investigated the relationship between plasma HCY and hsTnT levels in a community-based population.Methods: We related plasma levels of hsTnT to HCY levels in 1,497 participants (mean age, 62.4 years; 629 men, 868 women) from a community-based population in Beijing, People's Republic of China.Results: In multiple logistic regression models, serum HCY was associated with a higher likelihood of detectable hsTnT (odds ratio 1.5; 95% confidence interval 1.07–2.10; P=0.018). A subsequent subgroup analysis found that in subjects aged 65 years and older, the association between hsTnT levels and HCY levels was strengthened. The association between hsTnT and HCY was not present in the younger subgroup (<65 years old).Conclusion: Levels of serum HCY are associated with hsTnT levels in the elderly, indicating a relationship between HCY and subclinical myocardial damage.Keywords: epidemiology, myocardial damage, markers, relationship, subclinical
format	article
author	Cao R Bai Y Xu R Ye P
author_facet	Cao R Bai Y Xu R Ye P
author_sort	Cao R
title	Homocysteine is associated with plasma high-sensitivity cardiac troponin T levels in a community-dwelling population
title_short	Homocysteine is associated with plasma high-sensitivity cardiac troponin T levels in a community-dwelling population
title_full	Homocysteine is associated with plasma high-sensitivity cardiac troponin T levels in a community-dwelling population
title_fullStr	Homocysteine is associated with plasma high-sensitivity cardiac troponin T levels in a community-dwelling population
title_full_unstemmed	Homocysteine is associated with plasma high-sensitivity cardiac troponin T levels in a community-dwelling population
title_sort	homocysteine is associated with plasma high-sensitivity cardiac troponin t levels in a community-dwelling population
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/845cc964c0fd430a91ea20762020b630
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Homocysteine is associated with plasma high-sensitivity cardiac troponin T levels in a community-dwelling population

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