First assessment of POPs and cytochrome P450 expression in Cuvier’s beaked whales (Ziphius cavirostris) skin biopsies from the Mediterranean Sea

Abstract The Cuvier's beaked whale (Ziphius cavirostris) is one of the least known cetacean species worldwide. The decreasing population trend and associated threats has led to the IUCN categorising the Mediterranean subpopulation as Vulnerable on the Red List of Threatened Species. This study...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Matteo Baini, Cristina Panti, Maria Cristina Fossi, Paola Tepsich, Begoña Jiménez, Frazer Coomber, Alice Bartalini, Juan Muñoz-Arnanz, Aurelie Moulins, Massimiliano Rosso
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/845d2691644541489fca3120c2dc99cd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:845d2691644541489fca3120c2dc99cd
record_format	dspace
spelling	oai:doaj.org-article:845d2691644541489fca3120c2dc99cd2021-12-02T11:57:56ZFirst assessment of POPs and cytochrome P450 expression in Cuvier’s beaked whales (Ziphius cavirostris) skin biopsies from the Mediterranean Sea10.1038/s41598-020-78962-32045-2322https://doaj.org/article/845d2691644541489fca3120c2dc99cd2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78962-3https://doaj.org/toc/2045-2322Abstract The Cuvier's beaked whale (Ziphius cavirostris) is one of the least known cetacean species worldwide. The decreasing population trend and associated threats has led to the IUCN categorising the Mediterranean subpopulation as Vulnerable on the Red List of Threatened Species. This study aimed to investigate for the first time the ecotoxicological status of Cuvier's beaked whale in the NW Mediterranean Sea. The study sampled around the 20% of the individuals belonging to the Ligurian subpopulation, collecting skin biopsies from free-ranging specimens. The levels of polychlorinated biphenyl (PCBs), polybrominated diphenyl ethers (PBDEs) and induction of cytochrome's P450 (CYP1A1 and CYP2B isoforms) were evaluated. Results highlighted that the pattern of concentration for the target contaminants was PCBs > PBDEs and the accumulation values were linked to age and sex, with adult males showing significantly higher levels than juvenile. Concerns raised by the fact that 80% of the individuals had PCB levels above the toxicity threshold for negative physiological effects in marine mammals. Therefore, these findings shed light on this silent and serious threat never assessed in the Mediterranean Cuvier’s beaked whale population, indicating that anthropogenic pressures, including chemical pollution, may represent menaces for the conservation of this species in the Mediterranean Sea.Matteo BainiCristina PantiMaria Cristina FossiPaola TepsichBegoña JiménezFrazer CoomberAlice BartaliniJuan Muñoz-ArnanzAurelie MoulinsMassimiliano RossoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Matteo Baini Cristina Panti Maria Cristina Fossi Paola Tepsich Begoña Jiménez Frazer Coomber Alice Bartalini Juan Muñoz-Arnanz Aurelie Moulins Massimiliano Rosso First assessment of POPs and cytochrome P450 expression in Cuvier’s beaked whales (Ziphius cavirostris) skin biopsies from the Mediterranean Sea
description	Abstract The Cuvier's beaked whale (Ziphius cavirostris) is one of the least known cetacean species worldwide. The decreasing population trend and associated threats has led to the IUCN categorising the Mediterranean subpopulation as Vulnerable on the Red List of Threatened Species. This study aimed to investigate for the first time the ecotoxicological status of Cuvier's beaked whale in the NW Mediterranean Sea. The study sampled around the 20% of the individuals belonging to the Ligurian subpopulation, collecting skin biopsies from free-ranging specimens. The levels of polychlorinated biphenyl (PCBs), polybrominated diphenyl ethers (PBDEs) and induction of cytochrome's P450 (CYP1A1 and CYP2B isoforms) were evaluated. Results highlighted that the pattern of concentration for the target contaminants was PCBs > PBDEs and the accumulation values were linked to age and sex, with adult males showing significantly higher levels than juvenile. Concerns raised by the fact that 80% of the individuals had PCB levels above the toxicity threshold for negative physiological effects in marine mammals. Therefore, these findings shed light on this silent and serious threat never assessed in the Mediterranean Cuvier’s beaked whale population, indicating that anthropogenic pressures, including chemical pollution, may represent menaces for the conservation of this species in the Mediterranean Sea.
format	article
author	Matteo Baini Cristina Panti Maria Cristina Fossi Paola Tepsich Begoña Jiménez Frazer Coomber Alice Bartalini Juan Muñoz-Arnanz Aurelie Moulins Massimiliano Rosso
author_facet	Matteo Baini Cristina Panti Maria Cristina Fossi Paola Tepsich Begoña Jiménez Frazer Coomber Alice Bartalini Juan Muñoz-Arnanz Aurelie Moulins Massimiliano Rosso
author_sort	Matteo Baini
title	First assessment of POPs and cytochrome P450 expression in Cuvier’s beaked whales (Ziphius cavirostris) skin biopsies from the Mediterranean Sea
title_short	First assessment of POPs and cytochrome P450 expression in Cuvier’s beaked whales (Ziphius cavirostris) skin biopsies from the Mediterranean Sea
title_full	First assessment of POPs and cytochrome P450 expression in Cuvier’s beaked whales (Ziphius cavirostris) skin biopsies from the Mediterranean Sea
title_fullStr	First assessment of POPs and cytochrome P450 expression in Cuvier’s beaked whales (Ziphius cavirostris) skin biopsies from the Mediterranean Sea
title_full_unstemmed	First assessment of POPs and cytochrome P450 expression in Cuvier’s beaked whales (Ziphius cavirostris) skin biopsies from the Mediterranean Sea
title_sort	first assessment of pops and cytochrome p450 expression in cuvier’s beaked whales (ziphius cavirostris) skin biopsies from the mediterranean sea
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/845d2691644541489fca3120c2dc99cd
work_keys_str_mv	AT matteobaini firstassessmentofpopsandcytochromep450expressionincuviersbeakedwhalesziphiuscavirostrisskinbiopsiesfromthemediterraneansea AT cristinapanti firstassessmentofpopsandcytochromep450expressionincuviersbeakedwhalesziphiuscavirostrisskinbiopsiesfromthemediterraneansea AT mariacristinafossi firstassessmentofpopsandcytochromep450expressionincuviersbeakedwhalesziphiuscavirostrisskinbiopsiesfromthemediterraneansea AT paolatepsich firstassessmentofpopsandcytochromep450expressionincuviersbeakedwhalesziphiuscavirostrisskinbiopsiesfromthemediterraneansea AT begonajimenez firstassessmentofpopsandcytochromep450expressionincuviersbeakedwhalesziphiuscavirostrisskinbiopsiesfromthemediterraneansea AT frazercoomber firstassessmentofpopsandcytochromep450expressionincuviersbeakedwhalesziphiuscavirostrisskinbiopsiesfromthemediterraneansea AT alicebartalini firstassessmentofpopsandcytochromep450expressionincuviersbeakedwhalesziphiuscavirostrisskinbiopsiesfromthemediterraneansea AT juanmunozarnanz firstassessmentofpopsandcytochromep450expressionincuviersbeakedwhalesziphiuscavirostrisskinbiopsiesfromthemediterraneansea AT aureliemoulins firstassessmentofpopsandcytochromep450expressionincuviersbeakedwhalesziphiuscavirostrisskinbiopsiesfromthemediterraneansea AT massimilianorosso firstassessmentofpopsandcytochromep450expressionincuviersbeakedwhalesziphiuscavirostrisskinbiopsiesfromthemediterraneansea
_version_	1718394818774695936

First assessment of POPs and cytochrome P450 expression in Cuvier’s beaked whales (Ziphius cavirostris) skin biopsies from the Mediterranean Sea

Ejemplares similares