Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance

Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance

Polycomb repressive complex 2 (PRC2) mediates gene silencing through chromatin reorganization by methylation of histone H3 lysine 27 (H3K27). Here, the authors present crystal structures of the inhibitor-bound wild-type and a mutant form of PRC2.

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Detalles Bibliográficos
Autores principales: Alexei Brooun, Ketan S. Gajiwala, Ya-Li Deng, Wei Liu, Ben Bolaños, Patrick Bingham, You-Ai He, Wade Diehl, Nicole Grable, Pei-Pei Kung, Scott Sutton, Karen A. Maegley, Xiu Yu, Al E. Stewart
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
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Acceso en línea:https://doaj.org/article/845df6d19e6c440e8657bbebe46e34a8
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Sumario:Polycomb repressive complex 2 (PRC2) mediates gene silencing through chromatin reorganization by methylation of histone H3 lysine 27 (H3K27). Here, the authors present crystal structures of the inhibitor-bound wild-type and a mutant form of PRC2.

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