Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance

Polycomb repressive complex 2 (PRC2) mediates gene silencing through chromatin reorganization by methylation of histone H3 lysine 27 (H3K27). Here, the authors present crystal structures of the inhibitor-bound wild-type and a mutant form of PRC2.

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Autores principales:	Alexei Brooun, Ketan S. Gajiwala, Ya-Li Deng, Wei Liu, Ben Bolaños, Patrick Bingham, You-Ai He, Wade Diehl, Nicole Grable, Pei-Pei Kung, Scott Sutton, Karen A. Maegley, Xiu Yu, Al E. Stewart
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/845df6d19e6c440e8657bbebe46e34a8
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spelling	oai:doaj.org-article:845df6d19e6c440e8657bbebe46e34a82021-12-02T16:49:26ZPolycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance10.1038/ncomms113842041-1723https://doaj.org/article/845df6d19e6c440e8657bbebe46e34a82016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11384https://doaj.org/toc/2041-1723Polycomb repressive complex 2 (PRC2) mediates gene silencing through chromatin reorganization by methylation of histone H3 lysine 27 (H3K27). Here, the authors present crystal structures of the inhibitor-bound wild-type and a mutant form of PRC2.Alexei BroounKetan S. GajiwalaYa-Li DengWei LiuBen BolañosPatrick BinghamYou-Ai HeWade DiehlNicole GrablePei-Pei KungScott SuttonKaren A. MaegleyXiu YuAl E. StewartNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexei Brooun Ketan S. Gajiwala Ya-Li Deng Wei Liu Ben Bolaños Patrick Bingham You-Ai He Wade Diehl Nicole Grable Pei-Pei Kung Scott Sutton Karen A. Maegley Xiu Yu Al E. Stewart Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance
description	Polycomb repressive complex 2 (PRC2) mediates gene silencing through chromatin reorganization by methylation of histone H3 lysine 27 (H3K27). Here, the authors present crystal structures of the inhibitor-bound wild-type and a mutant form of PRC2.
format	article
author	Alexei Brooun Ketan S. Gajiwala Ya-Li Deng Wei Liu Ben Bolaños Patrick Bingham You-Ai He Wade Diehl Nicole Grable Pei-Pei Kung Scott Sutton Karen A. Maegley Xiu Yu Al E. Stewart
author_facet	Alexei Brooun Ketan S. Gajiwala Ya-Li Deng Wei Liu Ben Bolaños Patrick Bingham You-Ai He Wade Diehl Nicole Grable Pei-Pei Kung Scott Sutton Karen A. Maegley Xiu Yu Al E. Stewart
author_sort	Alexei Brooun
title	Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance
title_short	Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance
title_full	Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance
title_fullStr	Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance
title_full_unstemmed	Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance
title_sort	polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/845df6d19e6c440e8657bbebe46e34a8
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Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance

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