<named-content content-type="genus-species">Cryptococcus gattii</named-content> in the Age of Whole-Genome Sequencing

ABSTRACT Cryptococcus gattii, the sister species of Cryptococcus neoformans, is an emerging pathogen which gained importance in connection with the ongoing cryptococcosis outbreak on Vancouver Island. Many molecular studies have divided this species into for major lineages: VGI, VGII, VGIII, and VGI...

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Autor principal:	Wieland Meyer
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2015
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/8463ac438a4d41a2907b79d7e5bdeada
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spelling	oai:doaj.org-article:8463ac438a4d41a2907b79d7e5bdeada2021-11-15T15:41:24Z<named-content content-type="genus-species">Cryptococcus gattii</named-content> in the Age of Whole-Genome Sequencing10.1128/mBio.01761-152150-7511https://doaj.org/article/8463ac438a4d41a2907b79d7e5bdeada2015-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01761-15https://doaj.org/toc/2150-7511ABSTRACT Cryptococcus gattii, the sister species of Cryptococcus neoformans, is an emerging pathogen which gained importance in connection with the ongoing cryptococcosis outbreak on Vancouver Island. Many molecular studies have divided this species into for major lineages: VGI, VGII, VGIII, and VGIV. This commentary summarizes the whole-genome sequencing (WGS) studies that have been carried out with this species, re-emphasizing the phylogenetic relationships, showing chromosomal rearrangements between those four groups, and identifying VGII as ancestral population within C. gattii. In addition, WGS specific to VGII, containing the Vancouver Island outbreak genotypes and those from the Pacific Northwest region of the United States, has placed the origin of this lineage within South America and identified specific genes responsible for either brain or lung infection. It also showed, that many genotypes are spread across a number of different continents, as has been previously shown by multilocus sequence typing (MLST). In addition, it showed that recombination occurs more frequently between mitochondrial than nuclear genomes.Wieland MeyerAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 6, Iss 6 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Wieland Meyer <named-content content-type="genus-species">Cryptococcus gattii</named-content> in the Age of Whole-Genome Sequencing
description	ABSTRACT Cryptococcus gattii, the sister species of Cryptococcus neoformans, is an emerging pathogen which gained importance in connection with the ongoing cryptococcosis outbreak on Vancouver Island. Many molecular studies have divided this species into for major lineages: VGI, VGII, VGIII, and VGIV. This commentary summarizes the whole-genome sequencing (WGS) studies that have been carried out with this species, re-emphasizing the phylogenetic relationships, showing chromosomal rearrangements between those four groups, and identifying VGII as ancestral population within C. gattii. In addition, WGS specific to VGII, containing the Vancouver Island outbreak genotypes and those from the Pacific Northwest region of the United States, has placed the origin of this lineage within South America and identified specific genes responsible for either brain or lung infection. It also showed, that many genotypes are spread across a number of different continents, as has been previously shown by multilocus sequence typing (MLST). In addition, it showed that recombination occurs more frequently between mitochondrial than nuclear genomes.
format	article
author	Wieland Meyer
author_facet	Wieland Meyer
author_sort	Wieland Meyer
title	<named-content content-type="genus-species">Cryptococcus gattii</named-content> in the Age of Whole-Genome Sequencing
title_short	<named-content content-type="genus-species">Cryptococcus gattii</named-content> in the Age of Whole-Genome Sequencing
title_full	<named-content content-type="genus-species">Cryptococcus gattii</named-content> in the Age of Whole-Genome Sequencing
title_fullStr	<named-content content-type="genus-species">Cryptococcus gattii</named-content> in the Age of Whole-Genome Sequencing
title_full_unstemmed	<named-content content-type="genus-species">Cryptococcus gattii</named-content> in the Age of Whole-Genome Sequencing
title_sort	<named-content content-type="genus-species">cryptococcus gattii</named-content> in the age of whole-genome sequencing
publisher	American Society for Microbiology
publishDate	2015
url	https://doaj.org/article/8463ac438a4d41a2907b79d7e5bdeada
work_keys_str_mv	AT wielandmeyer namedcontentcontenttypegenusspeciescryptococcusgattiinamedcontentintheageofwholegenomesequencing
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<named-content content-type="genus-species">Cryptococcus gattii</named-content> in the Age of Whole-Genome Sequencing

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