ASC filament formation serves as a signal amplification mechanism for inflammasomes

Inflammasomes regulate IL-1β family maturation and pyroptosis. Here the authors show that ASC oligomerization and the formation of ASC specks are needed for IL-1β processing, but are not required for pyroptosis, indicating distinct inflammasome regulatory pathways.

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Bibliographic Details
Main Authors:	Mathias S. Dick, Lorenzo Sborgi, Sebastian Rühl, Sebastian Hiller, Petr Broz
Format:	article
Language:	EN
Published:	Nature Portfolio 2016
Subjects:	Science Q
Online Access:	https://doaj.org/article/846a5b7a13d34863b94bbdb0151a87c3
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id	oai:doaj.org-article:846a5b7a13d34863b94bbdb0151a87c3
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spelling	oai:doaj.org-article:846a5b7a13d34863b94bbdb0151a87c32021-12-02T15:34:51ZASC filament formation serves as a signal amplification mechanism for inflammasomes10.1038/ncomms119292041-1723https://doaj.org/article/846a5b7a13d34863b94bbdb0151a87c32016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11929https://doaj.org/toc/2041-1723Inflammasomes regulate IL-1β family maturation and pyroptosis. Here the authors show that ASC oligomerization and the formation of ASC specks are needed for IL-1β processing, but are not required for pyroptosis, indicating distinct inflammasome regulatory pathways.Mathias S. DickLorenzo SborgiSebastian RühlSebastian HillerPetr BrozNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mathias S. Dick Lorenzo Sborgi Sebastian Rühl Sebastian Hiller Petr Broz ASC filament formation serves as a signal amplification mechanism for inflammasomes
description	Inflammasomes regulate IL-1β family maturation and pyroptosis. Here the authors show that ASC oligomerization and the formation of ASC specks are needed for IL-1β processing, but are not required for pyroptosis, indicating distinct inflammasome regulatory pathways.
format	article
author	Mathias S. Dick Lorenzo Sborgi Sebastian Rühl Sebastian Hiller Petr Broz
author_facet	Mathias S. Dick Lorenzo Sborgi Sebastian Rühl Sebastian Hiller Petr Broz
author_sort	Mathias S. Dick
title	ASC filament formation serves as a signal amplification mechanism for inflammasomes
title_short	ASC filament formation serves as a signal amplification mechanism for inflammasomes
title_full	ASC filament formation serves as a signal amplification mechanism for inflammasomes
title_fullStr	ASC filament formation serves as a signal amplification mechanism for inflammasomes
title_full_unstemmed	ASC filament formation serves as a signal amplification mechanism for inflammasomes
title_sort	asc filament formation serves as a signal amplification mechanism for inflammasomes
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/846a5b7a13d34863b94bbdb0151a87c3
work_keys_str_mv	AT mathiassdick ascfilamentformationservesasasignalamplificationmechanismforinflammasomes AT lorenzosborgi ascfilamentformationservesasasignalamplificationmechanismforinflammasomes AT sebastianruhl ascfilamentformationservesasasignalamplificationmechanismforinflammasomes AT sebastianhiller ascfilamentformationservesasasignalamplificationmechanismforinflammasomes AT petrbroz ascfilamentformationservesasasignalamplificationmechanismforinflammasomes
_version_	1718386729950380032

ASC filament formation serves as a signal amplification mechanism for inflammasomes

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