Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes

Oocyte meiosis must achieve spindle bipolarization without predefined spatial cues. Yoshida et al. demonstrate that spindle bipolarization during meiosis I in mouse oocytes requires kinetochores to prevent chromosome segregation errors, a phenomenon that does not occur in error-prone human oocytes.

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Autores principales: Shuhei Yoshida, Sui Nishiyama, Lisa Lister, Shu Hashimoto, Tappei Mishina, Aurélien Courtois, Hirohisa Kyogoku, Takaya Abe, Aki Shiraishi, Meenakshi Choudhary, Yoshiharu Nakaoka, Mary Herbert, Tomoya S. Kitajima
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/846a65e485104228b1fc63d20e3f1d9c
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spelling oai:doaj.org-article:846a65e485104228b1fc63d20e3f1d9c2021-12-02T14:47:36ZPrc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes10.1038/s41467-020-16488-y2041-1723https://doaj.org/article/846a65e485104228b1fc63d20e3f1d9c2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16488-yhttps://doaj.org/toc/2041-1723Oocyte meiosis must achieve spindle bipolarization without predefined spatial cues. Yoshida et al. demonstrate that spindle bipolarization during meiosis I in mouse oocytes requires kinetochores to prevent chromosome segregation errors, a phenomenon that does not occur in error-prone human oocytes.Shuhei YoshidaSui NishiyamaLisa ListerShu HashimotoTappei MishinaAurélien CourtoisHirohisa KyogokuTakaya AbeAki ShiraishiMeenakshi ChoudharyYoshiharu NakaokaMary HerbertTomoya S. KitajimaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Shuhei Yoshida
Sui Nishiyama
Lisa Lister
Shu Hashimoto
Tappei Mishina
Aurélien Courtois
Hirohisa Kyogoku
Takaya Abe
Aki Shiraishi
Meenakshi Choudhary
Yoshiharu Nakaoka
Mary Herbert
Tomoya S. Kitajima
Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes
description Oocyte meiosis must achieve spindle bipolarization without predefined spatial cues. Yoshida et al. demonstrate that spindle bipolarization during meiosis I in mouse oocytes requires kinetochores to prevent chromosome segregation errors, a phenomenon that does not occur in error-prone human oocytes.
format article
author Shuhei Yoshida
Sui Nishiyama
Lisa Lister
Shu Hashimoto
Tappei Mishina
Aurélien Courtois
Hirohisa Kyogoku
Takaya Abe
Aki Shiraishi
Meenakshi Choudhary
Yoshiharu Nakaoka
Mary Herbert
Tomoya S. Kitajima
author_facet Shuhei Yoshida
Sui Nishiyama
Lisa Lister
Shu Hashimoto
Tappei Mishina
Aurélien Courtois
Hirohisa Kyogoku
Takaya Abe
Aki Shiraishi
Meenakshi Choudhary
Yoshiharu Nakaoka
Mary Herbert
Tomoya S. Kitajima
author_sort Shuhei Yoshida
title Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes
title_short Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes
title_full Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes
title_fullStr Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes
title_full_unstemmed Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes
title_sort prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis i in mouse oocytes
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/846a65e485104228b1fc63d20e3f1d9c
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