The effectiveness of a nonalcoholic disinfectant containing metal ions, with broad antimicrobial activity

Abstract Disinfectants have different efficacies depending on their use and the target microorganism. This study aimed to evaluate the efficacy and safety of our new nonalcoholic disinfectant, which consists mainly of metal ions. According to the 17th revised Japanese Pharmacopoeia and ASTM internat...

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Autores principales:	Tokuhiro Matsubara, Shuichi Maki, Yukiko Toshimori
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/846a8992e43d4a51838946ae43e335b1
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spelling	oai:doaj.org-article:846a8992e43d4a51838946ae43e335b12021-12-02T14:12:07ZThe effectiveness of a nonalcoholic disinfectant containing metal ions, with broad antimicrobial activity10.1038/s41598-020-80443-62045-2322https://doaj.org/article/846a8992e43d4a51838946ae43e335b12021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80443-6https://doaj.org/toc/2045-2322Abstract Disinfectants have different efficacies depending on their use and the target microorganism. This study aimed to evaluate the efficacy and safety of our new nonalcoholic disinfectant, which consists mainly of metal ions. According to the 17th revised Japanese Pharmacopoeia and ASTM international E1052 method, the bactericidal and virucidal efficacy of this new disinfectant against 13 microorganisms was evaluated by the in vitro quantitative suspension test. Additionally, the disinfectant cytotoxicity against multiple cell lines was examined. Then, a safety test using a human open patch test was performed with 26 healthy volunteers. This disinfectant showed strong bactericidal and virucidal activities: all microorganisms except enterovirus were inactivated very quickly. The infectivity of 12 microbial strains was eliminated within 5 min of disinfectant exposure. Additionally, this disinfectant showed little acute cytotoxicity in vitro. All volunteers were negative in the human open patch test. Our new disinfectant has a broad spectrum of microbial targets, is safe for human skin, and demonstrates no cytotoxicity. This disinfectant could prevent common microbial infections.Tokuhiro MatsubaraShuichi MakiYukiko ToshimoriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tokuhiro Matsubara Shuichi Maki Yukiko Toshimori The effectiveness of a nonalcoholic disinfectant containing metal ions, with broad antimicrobial activity
description	Abstract Disinfectants have different efficacies depending on their use and the target microorganism. This study aimed to evaluate the efficacy and safety of our new nonalcoholic disinfectant, which consists mainly of metal ions. According to the 17th revised Japanese Pharmacopoeia and ASTM international E1052 method, the bactericidal and virucidal efficacy of this new disinfectant against 13 microorganisms was evaluated by the in vitro quantitative suspension test. Additionally, the disinfectant cytotoxicity against multiple cell lines was examined. Then, a safety test using a human open patch test was performed with 26 healthy volunteers. This disinfectant showed strong bactericidal and virucidal activities: all microorganisms except enterovirus were inactivated very quickly. The infectivity of 12 microbial strains was eliminated within 5 min of disinfectant exposure. Additionally, this disinfectant showed little acute cytotoxicity in vitro. All volunteers were negative in the human open patch test. Our new disinfectant has a broad spectrum of microbial targets, is safe for human skin, and demonstrates no cytotoxicity. This disinfectant could prevent common microbial infections.
format	article
author	Tokuhiro Matsubara Shuichi Maki Yukiko Toshimori
author_facet	Tokuhiro Matsubara Shuichi Maki Yukiko Toshimori
author_sort	Tokuhiro Matsubara
title	The effectiveness of a nonalcoholic disinfectant containing metal ions, with broad antimicrobial activity
title_short	The effectiveness of a nonalcoholic disinfectant containing metal ions, with broad antimicrobial activity
title_full	The effectiveness of a nonalcoholic disinfectant containing metal ions, with broad antimicrobial activity
title_fullStr	The effectiveness of a nonalcoholic disinfectant containing metal ions, with broad antimicrobial activity
title_full_unstemmed	The effectiveness of a nonalcoholic disinfectant containing metal ions, with broad antimicrobial activity
title_sort	effectiveness of a nonalcoholic disinfectant containing metal ions, with broad antimicrobial activity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/846a8992e43d4a51838946ae43e335b1
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The effectiveness of a nonalcoholic disinfectant containing metal ions, with broad antimicrobial activity

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