Study of perinatal transmission of SARS-CoV-2 in a Mexican public hospital

Objectives: COVID-19 is a viral transmissible disease and there is limited evidence on vertical transmission and prevalence of SARS-CoV-2 during pregnancy, birth, and the postnatal period. This descriptive cross-sectional study aimed to evaluate the possible perinatal transmission of SARS-CoV-2 in m...

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Autores principales:	Adriana Ramírez-Rosas, Tizziani Benitez-Guerrero, Karina Corona-Cervantes, Juan Manuel Vélez-Ixta, Norma Gabriela Zavala-Torres, Jazmin Cuenca-Leija, Sarahi Martínez-Pichardo, María Esther Landero-Montes-de-Oca, Fernando Guadalupe Bastida-González, Paola Berenice Zárate-Segura, Jaime García-Mena
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Perinatal transmission COVID-19 Human milk SARS-CoV-2 RT-qPCR RT-ddPCR Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/846b3bc4ddd44be49855b2354a60421c
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spelling	oai:doaj.org-article:846b3bc4ddd44be49855b2354a60421c2021-11-12T04:27:16ZStudy of perinatal transmission of SARS-CoV-2 in a Mexican public hospital1201-971210.1016/j.ijid.2021.10.006https://doaj.org/article/846b3bc4ddd44be49855b2354a60421c2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1201971221007906https://doaj.org/toc/1201-9712Objectives: COVID-19 is a viral transmissible disease and there is limited evidence on vertical transmission and prevalence of SARS-CoV-2 during pregnancy, birth, and the postnatal period. This descriptive cross-sectional study aimed to evaluate the possible perinatal transmission of SARS-CoV-2 in mothers and neonates in a Mexican population. Methods: A total of 133 nasopharyngeal swab samples from mothers, 131 swab samples from neonates, and 140 colostrum samples were obtained, and the presence of SARS-CoV-2 was determined by qPCR. Results: One in eight asymptomatic 38–39 weeks’ pregnant women were positive for the presence of SARS-CoV-2 in nasopharyngeal swabs taken just before delivery; and one in 12 nasopharyngeal swabs collected from neonates immediately after delivery without breast feeding were also positive. It was also determined that one in 47 colostrum/milk samples were positive for the test. In addition, there was no association between positive results and any collected metadata of mothers or newborns. Conclusions: Asymptomatic women carried the SARS-CoV-2 virus during delivery, with perinatal transmission of SARS-CoV-2 to newborns. Since neonates were sampled immediately after birth, the detection of positive cases might be due to infection by the virus in utero.Adriana Ramírez-RosasTizziani Benitez-GuerreroKarina Corona-CervantesJuan Manuel Vélez-IxtaNorma Gabriela Zavala-TorresJazmin Cuenca-LeijaSarahi Martínez-PichardoMaría Esther Landero-Montes-de-OcaFernando Guadalupe Bastida-GonzálezPaola Berenice Zárate-SeguraJaime García-MenaElsevierarticlePerinatal transmissionCOVID-19Human milkSARS-CoV-2RT-qPCRRT-ddPCRInfectious and parasitic diseasesRC109-216ENInternational Journal of Infectious Diseases, Vol 113, Iss , Pp 225-232 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Perinatal transmission COVID-19 Human milk SARS-CoV-2 RT-qPCR RT-ddPCR Infectious and parasitic diseases RC109-216
spellingShingle	Perinatal transmission COVID-19 Human milk SARS-CoV-2 RT-qPCR RT-ddPCR Infectious and parasitic diseases RC109-216 Adriana Ramírez-Rosas Tizziani Benitez-Guerrero Karina Corona-Cervantes Juan Manuel Vélez-Ixta Norma Gabriela Zavala-Torres Jazmin Cuenca-Leija Sarahi Martínez-Pichardo María Esther Landero-Montes-de-Oca Fernando Guadalupe Bastida-González Paola Berenice Zárate-Segura Jaime García-Mena Study of perinatal transmission of SARS-CoV-2 in a Mexican public hospital
description	Objectives: COVID-19 is a viral transmissible disease and there is limited evidence on vertical transmission and prevalence of SARS-CoV-2 during pregnancy, birth, and the postnatal period. This descriptive cross-sectional study aimed to evaluate the possible perinatal transmission of SARS-CoV-2 in mothers and neonates in a Mexican population. Methods: A total of 133 nasopharyngeal swab samples from mothers, 131 swab samples from neonates, and 140 colostrum samples were obtained, and the presence of SARS-CoV-2 was determined by qPCR. Results: One in eight asymptomatic 38–39 weeks’ pregnant women were positive for the presence of SARS-CoV-2 in nasopharyngeal swabs taken just before delivery; and one in 12 nasopharyngeal swabs collected from neonates immediately after delivery without breast feeding were also positive. It was also determined that one in 47 colostrum/milk samples were positive for the test. In addition, there was no association between positive results and any collected metadata of mothers or newborns. Conclusions: Asymptomatic women carried the SARS-CoV-2 virus during delivery, with perinatal transmission of SARS-CoV-2 to newborns. Since neonates were sampled immediately after birth, the detection of positive cases might be due to infection by the virus in utero.
format	article
author	Adriana Ramírez-Rosas Tizziani Benitez-Guerrero Karina Corona-Cervantes Juan Manuel Vélez-Ixta Norma Gabriela Zavala-Torres Jazmin Cuenca-Leija Sarahi Martínez-Pichardo María Esther Landero-Montes-de-Oca Fernando Guadalupe Bastida-González Paola Berenice Zárate-Segura Jaime García-Mena
author_facet	Adriana Ramírez-Rosas Tizziani Benitez-Guerrero Karina Corona-Cervantes Juan Manuel Vélez-Ixta Norma Gabriela Zavala-Torres Jazmin Cuenca-Leija Sarahi Martínez-Pichardo María Esther Landero-Montes-de-Oca Fernando Guadalupe Bastida-González Paola Berenice Zárate-Segura Jaime García-Mena
author_sort	Adriana Ramírez-Rosas
title	Study of perinatal transmission of SARS-CoV-2 in a Mexican public hospital
title_short	Study of perinatal transmission of SARS-CoV-2 in a Mexican public hospital
title_full	Study of perinatal transmission of SARS-CoV-2 in a Mexican public hospital
title_fullStr	Study of perinatal transmission of SARS-CoV-2 in a Mexican public hospital
title_full_unstemmed	Study of perinatal transmission of SARS-CoV-2 in a Mexican public hospital
title_sort	study of perinatal transmission of sars-cov-2 in a mexican public hospital
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/846b3bc4ddd44be49855b2354a60421c
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Study of perinatal transmission of SARS-CoV-2 in a Mexican public hospital

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