Modular barcode beads for microfluidic single cell genomics

Abstract Barcode beads allow efficient nucleic acid tagging in single cell genomics. Current barcode designs, however, are fabricated with a particular application in mind. Repurposing to novel targets, or altering to add additional targets as information is obtained is possible but the result is su...

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Detalles Bibliográficos
Autores principales:	Cyrille L. Delley, Adam R. Abate
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/846c400e3a97429d89adbedb88153f6c
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id	oai:doaj.org-article:846c400e3a97429d89adbedb88153f6c
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spelling	oai:doaj.org-article:846c400e3a97429d89adbedb88153f6c2021-12-02T15:00:40ZModular barcode beads for microfluidic single cell genomics10.1038/s41598-021-90255-x2045-2322https://doaj.org/article/846c400e3a97429d89adbedb88153f6c2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90255-xhttps://doaj.org/toc/2045-2322Abstract Barcode beads allow efficient nucleic acid tagging in single cell genomics. Current barcode designs, however, are fabricated with a particular application in mind. Repurposing to novel targets, or altering to add additional targets as information is obtained is possible but the result is suboptimal. Here, we describe a modular framework that simplifies generation of multifunctional beads and allows their easy extension to new targets.Cyrille L. DelleyAdam R. AbateNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cyrille L. Delley Adam R. Abate Modular barcode beads for microfluidic single cell genomics
description	Abstract Barcode beads allow efficient nucleic acid tagging in single cell genomics. Current barcode designs, however, are fabricated with a particular application in mind. Repurposing to novel targets, or altering to add additional targets as information is obtained is possible but the result is suboptimal. Here, we describe a modular framework that simplifies generation of multifunctional beads and allows their easy extension to new targets.
format	article
author	Cyrille L. Delley Adam R. Abate
author_facet	Cyrille L. Delley Adam R. Abate
author_sort	Cyrille L. Delley
title	Modular barcode beads for microfluidic single cell genomics
title_short	Modular barcode beads for microfluidic single cell genomics
title_full	Modular barcode beads for microfluidic single cell genomics
title_fullStr	Modular barcode beads for microfluidic single cell genomics
title_full_unstemmed	Modular barcode beads for microfluidic single cell genomics
title_sort	modular barcode beads for microfluidic single cell genomics
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/846c400e3a97429d89adbedb88153f6c
work_keys_str_mv	AT cyrilleldelley modularbarcodebeadsformicrofluidicsinglecellgenomics AT adamrabate modularbarcodebeadsformicrofluidicsinglecellgenomics
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Modular barcode beads for microfluidic single cell genomics

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