Neutrophil accumulation within tissues: A damage x healing dichotomy

The abundance of neutrophils in human circulation, their fast mobilization from blood to tissues, along with their alleged short life-span led to the image of neutrophils as a homogeneous cell type designed to fight infections and die in the process. Additionally, their granule content and capacity...

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Autores principales:	Karen Marques Oliveira-Costa, Gustavo B. Menezes, Heitor A. Paula Neto
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Neutrophil Sterile injury Liver necrosis Resolution of inflammation Tissue repair Immunology Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/846c66d099194fb9a10d70f4ea45f188
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spelling	oai:doaj.org-article:846c66d099194fb9a10d70f4ea45f1882021-11-14T04:30:36ZNeutrophil accumulation within tissues: A damage x healing dichotomy0753-332210.1016/j.biopha.2021.112422https://doaj.org/article/846c66d099194fb9a10d70f4ea45f1882022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221012087https://doaj.org/toc/0753-3322The abundance of neutrophils in human circulation, their fast mobilization from blood to tissues, along with their alleged short life-span led to the image of neutrophils as a homogeneous cell type designed to fight infections and die in the process. Additionally, their granule content and capacity to produce molecules with considerable cytotoxic potential, lead to the general belief that neutrophil activation inexorably results in side effect of extensive tissue injury. Neutrophil activation in fact causes tissue injury as an adverse effect, but it seems that this is restricted to particular pathological situations and more of an “exception to the rule”. Here we review evidences arising especially from intravital microscopy studies that demonstrate neutrophils as cells endowed with sophisticated mechanisms and able to engage in complex interactions as to minimize damage and optimize their effector functions. Moreover, neutrophil infiltration may even contribute to tissue healing and repair which may altogether demand a reexamination of current anti-inflammatory therapies that have neutrophil migration and activation as a target.Karen Marques Oliveira-CostaGustavo B. MenezesHeitor A. Paula NetoElsevierarticleNeutrophilSterile injuryLiver necrosisResolution of inflammationTissue repairImmunologyTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112422- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neutrophil Sterile injury Liver necrosis Resolution of inflammation Tissue repair Immunology Therapeutics. Pharmacology RM1-950
spellingShingle	Neutrophil Sterile injury Liver necrosis Resolution of inflammation Tissue repair Immunology Therapeutics. Pharmacology RM1-950 Karen Marques Oliveira-Costa Gustavo B. Menezes Heitor A. Paula Neto Neutrophil accumulation within tissues: A damage x healing dichotomy
description	The abundance of neutrophils in human circulation, their fast mobilization from blood to tissues, along with their alleged short life-span led to the image of neutrophils as a homogeneous cell type designed to fight infections and die in the process. Additionally, their granule content and capacity to produce molecules with considerable cytotoxic potential, lead to the general belief that neutrophil activation inexorably results in side effect of extensive tissue injury. Neutrophil activation in fact causes tissue injury as an adverse effect, but it seems that this is restricted to particular pathological situations and more of an “exception to the rule”. Here we review evidences arising especially from intravital microscopy studies that demonstrate neutrophils as cells endowed with sophisticated mechanisms and able to engage in complex interactions as to minimize damage and optimize their effector functions. Moreover, neutrophil infiltration may even contribute to tissue healing and repair which may altogether demand a reexamination of current anti-inflammatory therapies that have neutrophil migration and activation as a target.
format	article
author	Karen Marques Oliveira-Costa Gustavo B. Menezes Heitor A. Paula Neto
author_facet	Karen Marques Oliveira-Costa Gustavo B. Menezes Heitor A. Paula Neto
author_sort	Karen Marques Oliveira-Costa
title	Neutrophil accumulation within tissues: A damage x healing dichotomy
title_short	Neutrophil accumulation within tissues: A damage x healing dichotomy
title_full	Neutrophil accumulation within tissues: A damage x healing dichotomy
title_fullStr	Neutrophil accumulation within tissues: A damage x healing dichotomy
title_full_unstemmed	Neutrophil accumulation within tissues: A damage x healing dichotomy
title_sort	neutrophil accumulation within tissues: a damage x healing dichotomy
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/846c66d099194fb9a10d70f4ea45f188
work_keys_str_mv	AT karenmarquesoliveiracosta neutrophilaccumulationwithintissuesadamagexhealingdichotomy AT gustavobmenezes neutrophilaccumulationwithintissuesadamagexhealingdichotomy AT heitorapaulaneto neutrophilaccumulationwithintissuesadamagexhealingdichotomy
_version_	1718429966904852480

Neutrophil accumulation within tissues: A damage x healing dichotomy

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