Prolonged corrected QT interval in hospitalized patients with coronavirus disease 2019 in Dubai, United Arab Emirates: a single-center, retrospective study

Objective To evaluate the association of a prolonged corrected QT (QTc) interval in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and its association with in-patient mortality. Methods A cohort of 745 patients were recruited from a single center between 1 March 2020 and 31 M...

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Autores principales:	Sameera Mohamed Ali, Anas Musa, Khalifa Omar Muhammed, Sumbul Javed, Mohamed Al Raqabani, Basem Adnan Baradie, Marian Sobhi Gargousa, Oghowan AbdelRahman Osman, Salah AlDeen Roqia, Jeyaseelan Lakshmanan, Haitham Al Hashemi, Fahad Omar Baslaib
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/846ddcff5f5a483d93def202d6573510
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spelling	oai:doaj.org-article:846ddcff5f5a483d93def202d65735102021-12-02T08:04:24ZProlonged corrected QT interval in hospitalized patients with coronavirus disease 2019 in Dubai, United Arab Emirates: a single-center, retrospective study1473-230010.1177/03000605211056834https://doaj.org/article/846ddcff5f5a483d93def202d65735102021-11-01T00:00:00Zhttps://doi.org/10.1177/03000605211056834https://doaj.org/toc/1473-2300Objective To evaluate the association of a prolonged corrected QT (QTc) interval in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and its association with in-patient mortality. Methods A cohort of 745 patients were recruited from a single center between 1 March 2020 and 31 May 2020. We analyzed the factors associated with a prolonged QTc and mortality. Results A prolonged QTc interval >450 ms was found in 27% of patients admitted with SARS-CoV-2 infection. These patients were predominantly older, on a ventilator, and had hypertension, diabetes mellitus, or ischemic heart disease. They also had high troponin and D-dimer concentrations. A prolonged QTc interval had a significant association with the requirement of ventilator support and was associated with an increased odds of mortality. Patients who died were older than 55 years, and had high troponin, D-dimer, creatinine, procalcitonin, and ferritin concentrations, a high white blood cell count, and abnormal potassium concentrations (hypo- or hyperkalemia). Conclusions A prolonged QTc interval is common in patients with SARS-CoV-2 infection and it is associated with worse outcomes. Older individuals and those with comorbidities should have an electrocardiogram performed, which is noninvasive and easily available, on admission to hospital to identify high-risk patients.Sameera Mohamed AliAnas MusaKhalifa Omar MuhammedSumbul JavedMohamed Al RaqabaniBasem Adnan BaradieMarian Sobhi GargousaOghowan AbdelRahman OsmanSalah AlDeen RoqiaJeyaseelan LakshmananHaitham Al HashemiFahad Omar BaslaibSAGE PublishingarticleMedicine (General)R5-920ENJournal of International Medical Research, Vol 49 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Sameera Mohamed Ali Anas Musa Khalifa Omar Muhammed Sumbul Javed Mohamed Al Raqabani Basem Adnan Baradie Marian Sobhi Gargousa Oghowan AbdelRahman Osman Salah AlDeen Roqia Jeyaseelan Lakshmanan Haitham Al Hashemi Fahad Omar Baslaib Prolonged corrected QT interval in hospitalized patients with coronavirus disease 2019 in Dubai, United Arab Emirates: a single-center, retrospective study
description	Objective To evaluate the association of a prolonged corrected QT (QTc) interval in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and its association with in-patient mortality. Methods A cohort of 745 patients were recruited from a single center between 1 March 2020 and 31 May 2020. We analyzed the factors associated with a prolonged QTc and mortality. Results A prolonged QTc interval >450 ms was found in 27% of patients admitted with SARS-CoV-2 infection. These patients were predominantly older, on a ventilator, and had hypertension, diabetes mellitus, or ischemic heart disease. They also had high troponin and D-dimer concentrations. A prolonged QTc interval had a significant association with the requirement of ventilator support and was associated with an increased odds of mortality. Patients who died were older than 55 years, and had high troponin, D-dimer, creatinine, procalcitonin, and ferritin concentrations, a high white blood cell count, and abnormal potassium concentrations (hypo- or hyperkalemia). Conclusions A prolonged QTc interval is common in patients with SARS-CoV-2 infection and it is associated with worse outcomes. Older individuals and those with comorbidities should have an electrocardiogram performed, which is noninvasive and easily available, on admission to hospital to identify high-risk patients.
format	article
author	Sameera Mohamed Ali Anas Musa Khalifa Omar Muhammed Sumbul Javed Mohamed Al Raqabani Basem Adnan Baradie Marian Sobhi Gargousa Oghowan AbdelRahman Osman Salah AlDeen Roqia Jeyaseelan Lakshmanan Haitham Al Hashemi Fahad Omar Baslaib
author_facet	Sameera Mohamed Ali Anas Musa Khalifa Omar Muhammed Sumbul Javed Mohamed Al Raqabani Basem Adnan Baradie Marian Sobhi Gargousa Oghowan AbdelRahman Osman Salah AlDeen Roqia Jeyaseelan Lakshmanan Haitham Al Hashemi Fahad Omar Baslaib
author_sort	Sameera Mohamed Ali
title	Prolonged corrected QT interval in hospitalized patients with coronavirus disease 2019 in Dubai, United Arab Emirates: a single-center, retrospective study
title_short	Prolonged corrected QT interval in hospitalized patients with coronavirus disease 2019 in Dubai, United Arab Emirates: a single-center, retrospective study
title_full	Prolonged corrected QT interval in hospitalized patients with coronavirus disease 2019 in Dubai, United Arab Emirates: a single-center, retrospective study
title_fullStr	Prolonged corrected QT interval in hospitalized patients with coronavirus disease 2019 in Dubai, United Arab Emirates: a single-center, retrospective study
title_full_unstemmed	Prolonged corrected QT interval in hospitalized patients with coronavirus disease 2019 in Dubai, United Arab Emirates: a single-center, retrospective study
title_sort	prolonged corrected qt interval in hospitalized patients with coronavirus disease 2019 in dubai, united arab emirates: a single-center, retrospective study
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/846ddcff5f5a483d93def202d6573510
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Prolonged corrected QT interval in hospitalized patients with coronavirus disease 2019 in Dubai, United Arab Emirates: a single-center, retrospective study

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