Gold nanoparticles enlighten the future of cancer theranostics

Jianfeng Guo,1 Kamil Rahme,2–4 Yan He,1 Lin-Lin Li,5 Justin D Holmes,3,4 Caitriona M O’Driscoll6 1School of Pharmaceutical Sciences, Jilin University, Changchun, China; 2Department of Sciences, Faculty of Natural and Applied Science, Notre Dame University (Louaize), Zouk Mosbeh,...

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Autores principales: Guo J, Rahme K, He Y, Li L, Holmes JD, O'Driscoll CM
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Lenguaje:EN
Publicado: Dove Medical Press 2017
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spelling oai:doaj.org-article:84718713ac72419c8a1debe84701a7752021-12-02T06:32:33ZGold nanoparticles enlighten the future of cancer theranostics1178-2013https://doaj.org/article/84718713ac72419c8a1debe84701a7752017-08-01T00:00:00Zhttps://www.dovepress.com/gold-nanoparticles-enlighten-the-future-of-cancer-theranostics-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Jianfeng Guo,1 Kamil Rahme,2–4 Yan He,1 Lin-Lin Li,5 Justin D Holmes,3,4 Caitriona M O’Driscoll6 1School of Pharmaceutical Sciences, Jilin University, Changchun, China; 2Department of Sciences, Faculty of Natural and Applied Science, Notre Dame University (Louaize), Zouk Mosbeh, Lebanon; 3Department of Chemistry, Tyndall National Institute, University College Cork, Cork, 4AMBER@CRANN, Trinity College Dublin, Dublin, Ireland; 5The First Hospital of Jilin University, Changchun, China; 6Pharmacodelivery Group, School of Pharmacy, University College Cork, Cork, Ireland Abstract: Development of multifunctional nanomaterials, one of the most interesting and advanced research areas in the field of nanotechnology, is anticipated to revolutionize cancer diagnosis and treatment. Gold nanoparticles (AuNPs) are now being widely utilized in bioimaging and phototherapy due to their tunable and highly sensitive optical and electronic properties (the surface plasmon resonance). As a new concept, termed “theranostics,” multifunctional AuNPs may contain diagnostic and therapeutic functions that can be integrated into one system, thereby simultaneously facilitating diagnosis and therapy and monitoring therapeutic responses. In this review, the important properties of AuNPs relevant to diagnostic and phototherapeutic applications such as structure, shape, optics, and surface chemistry are described. Barriers for translational development of theranostic AuNPs and recent advances in the application of AuNPs for cancer diagnosis, photothermal, and photodynamic therapy are discussed. Keywords: multifunctional gold nanoparticles, cancer bioimaging, cancer photothermal and photodynamic therapyGuo JRahme KHe YLi LHolmes JDO'Driscoll CMDove Medical PressarticleMultifunctional gold nanoparticlescancer bioimagingcancer photothermal and photodynamic therapy.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 6131-6152 (2017)
institution DOAJ
collection DOAJ
language EN
topic Multifunctional gold nanoparticles
cancer bioimaging
cancer photothermal and photodynamic therapy.
Medicine (General)
R5-920
spellingShingle Multifunctional gold nanoparticles
cancer bioimaging
cancer photothermal and photodynamic therapy.
Medicine (General)
R5-920
Guo J
Rahme K
He Y
Li L
Holmes JD
O'Driscoll CM
Gold nanoparticles enlighten the future of cancer theranostics
description Jianfeng Guo,1 Kamil Rahme,2–4 Yan He,1 Lin-Lin Li,5 Justin D Holmes,3,4 Caitriona M O’Driscoll6 1School of Pharmaceutical Sciences, Jilin University, Changchun, China; 2Department of Sciences, Faculty of Natural and Applied Science, Notre Dame University (Louaize), Zouk Mosbeh, Lebanon; 3Department of Chemistry, Tyndall National Institute, University College Cork, Cork, 4AMBER@CRANN, Trinity College Dublin, Dublin, Ireland; 5The First Hospital of Jilin University, Changchun, China; 6Pharmacodelivery Group, School of Pharmacy, University College Cork, Cork, Ireland Abstract: Development of multifunctional nanomaterials, one of the most interesting and advanced research areas in the field of nanotechnology, is anticipated to revolutionize cancer diagnosis and treatment. Gold nanoparticles (AuNPs) are now being widely utilized in bioimaging and phototherapy due to their tunable and highly sensitive optical and electronic properties (the surface plasmon resonance). As a new concept, termed “theranostics,” multifunctional AuNPs may contain diagnostic and therapeutic functions that can be integrated into one system, thereby simultaneously facilitating diagnosis and therapy and monitoring therapeutic responses. In this review, the important properties of AuNPs relevant to diagnostic and phototherapeutic applications such as structure, shape, optics, and surface chemistry are described. Barriers for translational development of theranostic AuNPs and recent advances in the application of AuNPs for cancer diagnosis, photothermal, and photodynamic therapy are discussed. Keywords: multifunctional gold nanoparticles, cancer bioimaging, cancer photothermal and photodynamic therapy
format article
author Guo J
Rahme K
He Y
Li L
Holmes JD
O'Driscoll CM
author_facet Guo J
Rahme K
He Y
Li L
Holmes JD
O'Driscoll CM
author_sort Guo J
title Gold nanoparticles enlighten the future of cancer theranostics
title_short Gold nanoparticles enlighten the future of cancer theranostics
title_full Gold nanoparticles enlighten the future of cancer theranostics
title_fullStr Gold nanoparticles enlighten the future of cancer theranostics
title_full_unstemmed Gold nanoparticles enlighten the future of cancer theranostics
title_sort gold nanoparticles enlighten the future of cancer theranostics
publisher Dove Medical Press
publishDate 2017
url https://doaj.org/article/84718713ac72419c8a1debe84701a775
work_keys_str_mv AT guoj goldnanoparticlesenlightenthefutureofcancertheranostics
AT rahmek goldnanoparticlesenlightenthefutureofcancertheranostics
AT hey goldnanoparticlesenlightenthefutureofcancertheranostics
AT lil goldnanoparticlesenlightenthefutureofcancertheranostics
AT holmesjd goldnanoparticlesenlightenthefutureofcancertheranostics
AT odriscollcm goldnanoparticlesenlightenthefutureofcancertheranostics
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