Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan

Pluripotent stem cells are thought to require a highly active proteostatic machinery. Here, the authors show that CCT8, a subunit of the proteostatic chaperonin complex, is increased in pluripotent stem cells, and that overexpression of CCT8 in worms increases cellular proteostasis and organismal lo...

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Autores principales:	Alireza Noormohammadi, Amirabbas Khodakarami, Ricardo Gutierrez-Garcia, Hyun Ju Lee, Seda Koyuncu, Tim König, Christina Schindler, Isabel Saez, Azra Fatima, Christoph Dieterich, David Vilchez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/84731adf22554679bbacd32bdb3db949
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spelling	oai:doaj.org-article:84731adf22554679bbacd32bdb3db9492021-12-02T15:35:41ZSomatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan10.1038/ncomms136492041-1723https://doaj.org/article/84731adf22554679bbacd32bdb3db9492016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13649https://doaj.org/toc/2041-1723Pluripotent stem cells are thought to require a highly active proteostatic machinery. Here, the authors show that CCT8, a subunit of the proteostatic chaperonin complex, is increased in pluripotent stem cells, and that overexpression of CCT8 in worms increases cellular proteostasis and organismal longevity.Alireza NoormohammadiAmirabbas KhodakaramiRicardo Gutierrez-GarciaHyun Ju LeeSeda KoyuncuTim KönigChristina SchindlerIsabel SaezAzra FatimaChristoph DieterichDavid VilchezNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alireza Noormohammadi Amirabbas Khodakarami Ricardo Gutierrez-Garcia Hyun Ju Lee Seda Koyuncu Tim König Christina Schindler Isabel Saez Azra Fatima Christoph Dieterich David Vilchez Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan
description	Pluripotent stem cells are thought to require a highly active proteostatic machinery. Here, the authors show that CCT8, a subunit of the proteostatic chaperonin complex, is increased in pluripotent stem cells, and that overexpression of CCT8 in worms increases cellular proteostasis and organismal longevity.
format	article
author	Alireza Noormohammadi Amirabbas Khodakarami Ricardo Gutierrez-Garcia Hyun Ju Lee Seda Koyuncu Tim König Christina Schindler Isabel Saez Azra Fatima Christoph Dieterich David Vilchez
author_facet	Alireza Noormohammadi Amirabbas Khodakarami Ricardo Gutierrez-Garcia Hyun Ju Lee Seda Koyuncu Tim König Christina Schindler Isabel Saez Azra Fatima Christoph Dieterich David Vilchez
author_sort	Alireza Noormohammadi
title	Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan
title_short	Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan
title_full	Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan
title_fullStr	Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan
title_full_unstemmed	Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan
title_sort	somatic increase of cct8 mimics proteostasis of human pluripotent stem cells and extends c. elegans lifespan
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/84731adf22554679bbacd32bdb3db949
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Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan

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