Use of pharmacotherapy for alcohol use disorder in Manitoba, Canada: A whole-population cohort study.

<h4>Objective</h4>Update the evidence on use of pharmacotherapy for alcohol use disorder in a Canadian population.<h4>Methods</h4>Using whole-population administrative data from Manitoba, Canada, we identified all residents age 12+ who were first diagnosed with alcohol use di...

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Autores principales:	Geoffrey Konrad, Christine Leong, James M Bolton, Heather J Prior, Michael T Paillé, Josh Nepon, Deepa Singal, Okechukwu Ekuma, Jennifer E Enns, Nathan C Nickel
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/84736410744842feb6121c618bc88fc1
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spelling	oai:doaj.org-article:84736410744842feb6121c618bc88fc12021-12-02T20:14:50ZUse of pharmacotherapy for alcohol use disorder in Manitoba, Canada: A whole-population cohort study.1932-620310.1371/journal.pone.0257025https://doaj.org/article/84736410744842feb6121c618bc88fc12021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257025https://doaj.org/toc/1932-6203<h4>Objective</h4>Update the evidence on use of pharmacotherapy for alcohol use disorder in a Canadian population.<h4>Methods</h4>Using whole-population administrative data from Manitoba, Canada, we identified all residents age 12+ who were first diagnosed with alcohol use disorder between April 1, 1996 and March 31, 2015, and compared characteristics of those who filled a prescription for naltrexone, acamprosate or disulfiram at least once during that period to those who did not fill a prescription for an alcohol use disorder medication.<h4>Results</h4>Only 1.3% of individuals with alcohol use disorder received pharmacotherapy (62.3% of prescriptions were for naltrexone, 39.4% for acamprosate, 7.5% for disulfiram). Most prescriptions came from family physicians in urban alcohol use disorder (53.6%) and psychiatrists (22.3%). Individuals were more likely to fill a prescription for alcohol use disorder medication if they lived in an urban vs rural environment (OR 2.25; 95% CI 1.83-2.77) or had a mood/anxiety disorder diagnosis vs no diagnosis (OR 2.40, 95% CI 1.98-2.90) in the five years before being diagnosed with alcohol use disorder.<h4>Conclusion</h4>Despite established evidence for the effectiveness of pharmacotherapy for alcohol use disorder, these medications continue to be profoundly underutilized in Canada.Geoffrey KonradChristine LeongJames M BoltonHeather J PriorMichael T PailléJosh NeponDeepa SingalOkechukwu EkumaJennifer E EnnsNathan C NickelPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257025 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Geoffrey Konrad Christine Leong James M Bolton Heather J Prior Michael T Paillé Josh Nepon Deepa Singal Okechukwu Ekuma Jennifer E Enns Nathan C Nickel Use of pharmacotherapy for alcohol use disorder in Manitoba, Canada: A whole-population cohort study.
description	<h4>Objective</h4>Update the evidence on use of pharmacotherapy for alcohol use disorder in a Canadian population.<h4>Methods</h4>Using whole-population administrative data from Manitoba, Canada, we identified all residents age 12+ who were first diagnosed with alcohol use disorder between April 1, 1996 and March 31, 2015, and compared characteristics of those who filled a prescription for naltrexone, acamprosate or disulfiram at least once during that period to those who did not fill a prescription for an alcohol use disorder medication.<h4>Results</h4>Only 1.3% of individuals with alcohol use disorder received pharmacotherapy (62.3% of prescriptions were for naltrexone, 39.4% for acamprosate, 7.5% for disulfiram). Most prescriptions came from family physicians in urban alcohol use disorder (53.6%) and psychiatrists (22.3%). Individuals were more likely to fill a prescription for alcohol use disorder medication if they lived in an urban vs rural environment (OR 2.25; 95% CI 1.83-2.77) or had a mood/anxiety disorder diagnosis vs no diagnosis (OR 2.40, 95% CI 1.98-2.90) in the five years before being diagnosed with alcohol use disorder.<h4>Conclusion</h4>Despite established evidence for the effectiveness of pharmacotherapy for alcohol use disorder, these medications continue to be profoundly underutilized in Canada.
format	article
author	Geoffrey Konrad Christine Leong James M Bolton Heather J Prior Michael T Paillé Josh Nepon Deepa Singal Okechukwu Ekuma Jennifer E Enns Nathan C Nickel
author_facet	Geoffrey Konrad Christine Leong James M Bolton Heather J Prior Michael T Paillé Josh Nepon Deepa Singal Okechukwu Ekuma Jennifer E Enns Nathan C Nickel
author_sort	Geoffrey Konrad
title	Use of pharmacotherapy for alcohol use disorder in Manitoba, Canada: A whole-population cohort study.
title_short	Use of pharmacotherapy for alcohol use disorder in Manitoba, Canada: A whole-population cohort study.
title_full	Use of pharmacotherapy for alcohol use disorder in Manitoba, Canada: A whole-population cohort study.
title_fullStr	Use of pharmacotherapy for alcohol use disorder in Manitoba, Canada: A whole-population cohort study.
title_full_unstemmed	Use of pharmacotherapy for alcohol use disorder in Manitoba, Canada: A whole-population cohort study.
title_sort	use of pharmacotherapy for alcohol use disorder in manitoba, canada: a whole-population cohort study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/84736410744842feb6121c618bc88fc1
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Use of pharmacotherapy for alcohol use disorder in Manitoba, Canada: A whole-population cohort study.

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