Active Site Gate Dynamics Modulate the Catalytic Activity of the Ubiquitination Enzyme E2-25K

Active Site Gate Dynamics Modulate the Catalytic Activity of the Ubiquitination Enzyme E2-25K

Abstract The ubiquitin proteasome system (UPS) signals for degradation of proteins through attachment of K48-linked polyubiquitin chains, or alterations in protein-protein recognition through attachment of K63-linked chains. Target proteins are ubiquitinated in three sequential chemical steps by a t...

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Autores principales: Manoj K. Rout, Brian L. Lee, Aiyang Lin, Wei Xiao, Leo Spyracopoulos
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/847413dcf7314bdbbe3d72508e66203f
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