Novel grid combined with peripheral distortion correction for ultra-widefield image grading of age-related macular degeneration

Patrick Oellers,1,* Inês Laíns,1,2,* Steven Mach,1 Shady Garas,1 Ivana K Kim,1 Demetrios G Vavvas,1 Joan W Miller,1 Deeba Husain,1 John B Miller1 1Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA; 2Faculty of Medici...

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Autores principales:	Oellers P, Laíns I, Mach S, Garas S, Kim IK, Vavvas DG, Miller JW, Husain D, Miller JB
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Ultra-widefield autofluorescence macular degeneration grid periphery drusen retinal pigment epithelium changes Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/847478450169430d89838ea0a4e005c0
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spelling	oai:doaj.org-article:847478450169430d89838ea0a4e005c02021-12-02T04:04:18ZNovel grid combined with peripheral distortion correction for ultra-widefield image grading of age-related macular degeneration1177-5483https://doaj.org/article/847478450169430d89838ea0a4e005c02017-11-01T00:00:00Zhttps://www.dovepress.com/novel-grid-combined-with-peripheral-distortion-correction-for-ultra-wi-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Patrick Oellers,1,* Inês Laíns,1,2,* Steven Mach,1 Shady Garas,1 Ivana K Kim,1 Demetrios G Vavvas,1 Joan W Miller,1 Deeba Husain,1 John B Miller1 1Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA; 2Faculty of Medicine, University of Coimbra, Coimbra, Portugal *These authors contributed equally to this work Purpose: Eyes with age-related macular degeneration (AMD) often harbor pathological changes in the retinal periphery and perimacular region. These extramacular changes have not been well classified, but may be phenotypically and functionally relevant. The purpose of this study was to demonstrate a novel grid to systematically study peripheral retinal abnormalities in AMD using geometric distortion-corrected ultra-widefield (UWF) imaging.Methods: This is a cross-sectional observational case series. Consecutive patients with AMD without any other coexisting vitreoretinal disease and control patients over age 50 without AMD or any other vitreoretinal disease were imaged using Optos 200 Tx. Captured 200° UWF images were corrected for peripheral geometric distortion using Optos transformation software. A newly developed grid to study perimacular and peripheral abnormalities in AMD was then projected onto the images.Results: Peripheral and perimacular changes such as drusen, retinal pigment epithelium changes and atrophy were found in patients with AMD. The presented grid in conjunction with geometric distortion-corrected UWF images allowed for systematic study of these peripheral changes in AMD.Conclusion: We present a novel grid to study peripheral and posterior pole changes in AMD. The grid is unique in that it adds a perimacular zone, which may be important in characterizing certain phenotypes in AMD. Our UWF images were corrected for geometric peripheral distortion to accurately reflect the anatomical dimensions of the retina. This grid offers a reliable and reproducible foundation for the exploration of peripheral retinal pathology associated with AMD. Keywords: ultra-widefield, autofluorescence, macular degeneration, grid, periphery, drusen, retinal pigment epithelium changesOellers PLaíns IMach SGaras SKim IKVavvas DGMiller JWHusain DMiller JBDove Medical PressarticleUltra-widefieldautofluorescencemacular degenerationgridperipherydrusenretinal pigment epithelium changesOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 1967-1974 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ultra-widefield autofluorescence macular degeneration grid periphery drusen retinal pigment epithelium changes Ophthalmology RE1-994
spellingShingle	Ultra-widefield autofluorescence macular degeneration grid periphery drusen retinal pigment epithelium changes Ophthalmology RE1-994 Oellers P Laíns I Mach S Garas S Kim IK Vavvas DG Miller JW Husain D Miller JB Novel grid combined with peripheral distortion correction for ultra-widefield image grading of age-related macular degeneration
description	Patrick Oellers,1,* Inês Laíns,1,2,* Steven Mach,1 Shady Garas,1 Ivana K Kim,1 Demetrios G Vavvas,1 Joan W Miller,1 Deeba Husain,1 John B Miller1 1Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA; 2Faculty of Medicine, University of Coimbra, Coimbra, Portugal *These authors contributed equally to this work Purpose: Eyes with age-related macular degeneration (AMD) often harbor pathological changes in the retinal periphery and perimacular region. These extramacular changes have not been well classified, but may be phenotypically and functionally relevant. The purpose of this study was to demonstrate a novel grid to systematically study peripheral retinal abnormalities in AMD using geometric distortion-corrected ultra-widefield (UWF) imaging.Methods: This is a cross-sectional observational case series. Consecutive patients with AMD without any other coexisting vitreoretinal disease and control patients over age 50 without AMD or any other vitreoretinal disease were imaged using Optos 200 Tx. Captured 200° UWF images were corrected for peripheral geometric distortion using Optos transformation software. A newly developed grid to study perimacular and peripheral abnormalities in AMD was then projected onto the images.Results: Peripheral and perimacular changes such as drusen, retinal pigment epithelium changes and atrophy were found in patients with AMD. The presented grid in conjunction with geometric distortion-corrected UWF images allowed for systematic study of these peripheral changes in AMD.Conclusion: We present a novel grid to study peripheral and posterior pole changes in AMD. The grid is unique in that it adds a perimacular zone, which may be important in characterizing certain phenotypes in AMD. Our UWF images were corrected for geometric peripheral distortion to accurately reflect the anatomical dimensions of the retina. This grid offers a reliable and reproducible foundation for the exploration of peripheral retinal pathology associated with AMD. Keywords: ultra-widefield, autofluorescence, macular degeneration, grid, periphery, drusen, retinal pigment epithelium changes
format	article
author	Oellers P Laíns I Mach S Garas S Kim IK Vavvas DG Miller JW Husain D Miller JB
author_facet	Oellers P Laíns I Mach S Garas S Kim IK Vavvas DG Miller JW Husain D Miller JB
author_sort	Oellers P
title	Novel grid combined with peripheral distortion correction for ultra-widefield image grading of age-related macular degeneration
title_short	Novel grid combined with peripheral distortion correction for ultra-widefield image grading of age-related macular degeneration
title_full	Novel grid combined with peripheral distortion correction for ultra-widefield image grading of age-related macular degeneration
title_fullStr	Novel grid combined with peripheral distortion correction for ultra-widefield image grading of age-related macular degeneration
title_full_unstemmed	Novel grid combined with peripheral distortion correction for ultra-widefield image grading of age-related macular degeneration
title_sort	novel grid combined with peripheral distortion correction for ultra-widefield image grading of age-related macular degeneration
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/847478450169430d89838ea0a4e005c0
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Novel grid combined with peripheral distortion correction for ultra-widefield image grading of age-related macular degeneration

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