Distinct mutational signatures characterize concurrent loss of polymerase proofreading and mismatch repair

Polymerase proofreading and the mismatch repair pathway maintain the fidelity of DNA replication. Here the authors show that tumors with concurrent loss of function of both pathways lead to mutation signatures that are not simply a sum of the signatures found in tumors involving single alteration.

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Autores principales:	N. J. Haradhvala, J. Kim, Y. E. Maruvka, P. Polak, D. Rosebrock, D. Livitz, J. M. Hess, I. Leshchiner, A. Kamburov, K. W. Mouw, M. S. Lawrence, G. Getz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/847499a0dbe4432598403e0c9420f9f4
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spelling	oai:doaj.org-article:847499a0dbe4432598403e0c9420f9f42021-12-02T16:49:49ZDistinct mutational signatures characterize concurrent loss of polymerase proofreading and mismatch repair10.1038/s41467-018-04002-42041-1723https://doaj.org/article/847499a0dbe4432598403e0c9420f9f42018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04002-4https://doaj.org/toc/2041-1723Polymerase proofreading and the mismatch repair pathway maintain the fidelity of DNA replication. Here the authors show that tumors with concurrent loss of function of both pathways lead to mutation signatures that are not simply a sum of the signatures found in tumors involving single alteration.N. J. HaradhvalaJ. KimY. E. MaruvkaP. PolakD. RosebrockD. LivitzJ. M. HessI. LeshchinerA. KamburovK. W. MouwM. S. LawrenceG. GetzNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q N. J. Haradhvala J. Kim Y. E. Maruvka P. Polak D. Rosebrock D. Livitz J. M. Hess I. Leshchiner A. Kamburov K. W. Mouw M. S. Lawrence G. Getz Distinct mutational signatures characterize concurrent loss of polymerase proofreading and mismatch repair
description	Polymerase proofreading and the mismatch repair pathway maintain the fidelity of DNA replication. Here the authors show that tumors with concurrent loss of function of both pathways lead to mutation signatures that are not simply a sum of the signatures found in tumors involving single alteration.
format	article
author	N. J. Haradhvala J. Kim Y. E. Maruvka P. Polak D. Rosebrock D. Livitz J. M. Hess I. Leshchiner A. Kamburov K. W. Mouw M. S. Lawrence G. Getz
author_facet	N. J. Haradhvala J. Kim Y. E. Maruvka P. Polak D. Rosebrock D. Livitz J. M. Hess I. Leshchiner A. Kamburov K. W. Mouw M. S. Lawrence G. Getz
author_sort	N. J. Haradhvala
title	Distinct mutational signatures characterize concurrent loss of polymerase proofreading and mismatch repair
title_short	Distinct mutational signatures characterize concurrent loss of polymerase proofreading and mismatch repair
title_full	Distinct mutational signatures characterize concurrent loss of polymerase proofreading and mismatch repair
title_fullStr	Distinct mutational signatures characterize concurrent loss of polymerase proofreading and mismatch repair
title_full_unstemmed	Distinct mutational signatures characterize concurrent loss of polymerase proofreading and mismatch repair
title_sort	distinct mutational signatures characterize concurrent loss of polymerase proofreading and mismatch repair
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/847499a0dbe4432598403e0c9420f9f4
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Distinct mutational signatures characterize concurrent loss of polymerase proofreading and mismatch repair

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