C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers

Nuclear import receptors (NIRs) regulate self-association of RNA-binding proteins as phase modifiers, while C9orf72-derived arginine-rich polydipeptides lead to aberrant phase transitions. Here the authors show in molecular basis how arginine-rich poly-dipeptides impede the ability of NIRs, particul...

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Autores principales:	Hitoki Nanaura, Honoka Kawamukai, Ayano Fujiwara, Takeru Uehara, Yuichiro Aiba, Mari Nakanishi, Tomo Shiota, Masaki Hibino, Pattama Wiriyasermkul, Sotaro Kikuchi, Riko Nagata, Masaya Matsubayashi, Yoichi Shinkai, Tatsuya Niwa, Taro Mannen, Naritaka Morikawa, Naohiko Iguchi, Takao Kiriyama, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Takashi Oda, Noriyuki Kodera, Sachiko Toma-Fukai, Mamoru Sato, Hideki Taguchi, Shushi Nagamori, Osami Shoji, Koichiro Ishimori, Hiroyoshi Matsumura, Kazuma Sugie, Tomohide Saio, Takuya Yoshizawa, Eiichiro Mori
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/84769c6bce8f47bf9553e2e7438eb8a6
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id	oai:doaj.org-article:84769c6bce8f47bf9553e2e7438eb8a6
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spelling	oai:doaj.org-article:84769c6bce8f47bf9553e2e7438eb8a62021-12-02T17:19:40ZC9orf72-derived arginine-rich poly-dipeptides impede phase modifiers10.1038/s41467-021-25560-02041-1723https://doaj.org/article/84769c6bce8f47bf9553e2e7438eb8a62021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25560-0https://doaj.org/toc/2041-1723Nuclear import receptors (NIRs) regulate self-association of RNA-binding proteins as phase modifiers, while C9orf72-derived arginine-rich polydipeptides lead to aberrant phase transitions. Here the authors show in molecular basis how arginine-rich poly-dipeptides impede the ability of NIRs, particularly Kapβ2.Hitoki NanauraHonoka KawamukaiAyano FujiwaraTakeru UeharaYuichiro AibaMari NakanishiTomo ShiotaMasaki HibinoPattama WiriyasermkulSotaro KikuchiRiko NagataMasaya MatsubayashiYoichi ShinkaiTatsuya NiwaTaro MannenNaritaka MorikawaNaohiko IguchiTakao KiriyamaKen MorishimaRintaro InoueMasaaki SugiyamaTakashi OdaNoriyuki KoderaSachiko Toma-FukaiMamoru SatoHideki TaguchiShushi NagamoriOsami ShojiKoichiro IshimoriHiroyoshi MatsumuraKazuma SugieTomohide SaioTakuya YoshizawaEiichiro MoriNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hitoki Nanaura Honoka Kawamukai Ayano Fujiwara Takeru Uehara Yuichiro Aiba Mari Nakanishi Tomo Shiota Masaki Hibino Pattama Wiriyasermkul Sotaro Kikuchi Riko Nagata Masaya Matsubayashi Yoichi Shinkai Tatsuya Niwa Taro Mannen Naritaka Morikawa Naohiko Iguchi Takao Kiriyama Ken Morishima Rintaro Inoue Masaaki Sugiyama Takashi Oda Noriyuki Kodera Sachiko Toma-Fukai Mamoru Sato Hideki Taguchi Shushi Nagamori Osami Shoji Koichiro Ishimori Hiroyoshi Matsumura Kazuma Sugie Tomohide Saio Takuya Yoshizawa Eiichiro Mori C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers
description	Nuclear import receptors (NIRs) regulate self-association of RNA-binding proteins as phase modifiers, while C9orf72-derived arginine-rich polydipeptides lead to aberrant phase transitions. Here the authors show in molecular basis how arginine-rich poly-dipeptides impede the ability of NIRs, particularly Kapβ2.
format	article
author	Hitoki Nanaura Honoka Kawamukai Ayano Fujiwara Takeru Uehara Yuichiro Aiba Mari Nakanishi Tomo Shiota Masaki Hibino Pattama Wiriyasermkul Sotaro Kikuchi Riko Nagata Masaya Matsubayashi Yoichi Shinkai Tatsuya Niwa Taro Mannen Naritaka Morikawa Naohiko Iguchi Takao Kiriyama Ken Morishima Rintaro Inoue Masaaki Sugiyama Takashi Oda Noriyuki Kodera Sachiko Toma-Fukai Mamoru Sato Hideki Taguchi Shushi Nagamori Osami Shoji Koichiro Ishimori Hiroyoshi Matsumura Kazuma Sugie Tomohide Saio Takuya Yoshizawa Eiichiro Mori
author_facet	Hitoki Nanaura Honoka Kawamukai Ayano Fujiwara Takeru Uehara Yuichiro Aiba Mari Nakanishi Tomo Shiota Masaki Hibino Pattama Wiriyasermkul Sotaro Kikuchi Riko Nagata Masaya Matsubayashi Yoichi Shinkai Tatsuya Niwa Taro Mannen Naritaka Morikawa Naohiko Iguchi Takao Kiriyama Ken Morishima Rintaro Inoue Masaaki Sugiyama Takashi Oda Noriyuki Kodera Sachiko Toma-Fukai Mamoru Sato Hideki Taguchi Shushi Nagamori Osami Shoji Koichiro Ishimori Hiroyoshi Matsumura Kazuma Sugie Tomohide Saio Takuya Yoshizawa Eiichiro Mori
author_sort	Hitoki Nanaura
title	C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers
title_short	C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers
title_full	C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers
title_fullStr	C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers
title_full_unstemmed	C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers
title_sort	c9orf72-derived arginine-rich poly-dipeptides impede phase modifiers
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/84769c6bce8f47bf9553e2e7438eb8a6
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C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers

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