Functional in vivo characterization of sox10 enhancers in neural crest and melanoma development
By performing ATAC-Seq on zebrafish melanoma tumours, Cunningham et al identify putative sox10 enhancers with embryonic activity in zebrafish. They identify a region upstream of sox10, termed peak5, that is needed for full expression of embryonic sox10 and for adult stripe patterning demonstrating a...
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Nature Portfolio
2021
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oai:doaj.org-article:847afc3cf583438186c5a7ab690ba4a32021-12-02T17:30:53ZFunctional in vivo characterization of sox10 enhancers in neural crest and melanoma development10.1038/s42003-021-02211-02399-3642https://doaj.org/article/847afc3cf583438186c5a7ab690ba4a32021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02211-0https://doaj.org/toc/2399-3642By performing ATAC-Seq on zebrafish melanoma tumours, Cunningham et al identify putative sox10 enhancers with embryonic activity in zebrafish. They identify a region upstream of sox10, termed peak5, that is needed for full expression of embryonic sox10 and for adult stripe patterning demonstrating an enhancer function for peak5 and provide insights into neural crest development and melanoma initiation.Rebecca L. CunninghamEva T. KramerSophia K. DeGeorgiaPaula M. GodoyAnna P. ZarovShayana SeneviratneVadim GriguraCharles K. KaufmanNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021) |
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DOAJ |
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Biology (General) QH301-705.5 |
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Biology (General) QH301-705.5 Rebecca L. Cunningham Eva T. Kramer Sophia K. DeGeorgia Paula M. Godoy Anna P. Zarov Shayana Seneviratne Vadim Grigura Charles K. Kaufman Functional in vivo characterization of sox10 enhancers in neural crest and melanoma development |
description |
By performing ATAC-Seq on zebrafish melanoma tumours, Cunningham et al identify putative sox10 enhancers with embryonic activity in zebrafish. They identify a region upstream of sox10, termed peak5, that is needed for full expression of embryonic sox10 and for adult stripe patterning demonstrating an enhancer function for peak5 and provide insights into neural crest development and melanoma initiation. |
format |
article |
author |
Rebecca L. Cunningham Eva T. Kramer Sophia K. DeGeorgia Paula M. Godoy Anna P. Zarov Shayana Seneviratne Vadim Grigura Charles K. Kaufman |
author_facet |
Rebecca L. Cunningham Eva T. Kramer Sophia K. DeGeorgia Paula M. Godoy Anna P. Zarov Shayana Seneviratne Vadim Grigura Charles K. Kaufman |
author_sort |
Rebecca L. Cunningham |
title |
Functional in vivo characterization of sox10 enhancers in neural crest and melanoma development |
title_short |
Functional in vivo characterization of sox10 enhancers in neural crest and melanoma development |
title_full |
Functional in vivo characterization of sox10 enhancers in neural crest and melanoma development |
title_fullStr |
Functional in vivo characterization of sox10 enhancers in neural crest and melanoma development |
title_full_unstemmed |
Functional in vivo characterization of sox10 enhancers in neural crest and melanoma development |
title_sort |
functional in vivo characterization of sox10 enhancers in neural crest and melanoma development |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/847afc3cf583438186c5a7ab690ba4a3 |
work_keys_str_mv |
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