Functional in vivo characterization of sox10 enhancers in neural crest and melanoma development

By performing ATAC-Seq on zebrafish melanoma tumours, Cunningham et al identify putative sox10 enhancers with embryonic activity in zebrafish. They identify a region upstream of sox10, termed peak5, that is needed for full expression of embryonic sox10 and for adult stripe patterning demonstrating a...

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Autores principales: Rebecca L. Cunningham, Eva T. Kramer, Sophia K. DeGeorgia, Paula M. Godoy, Anna P. Zarov, Shayana Seneviratne, Vadim Grigura, Charles K. Kaufman
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/847afc3cf583438186c5a7ab690ba4a3
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spelling oai:doaj.org-article:847afc3cf583438186c5a7ab690ba4a32021-12-02T17:30:53ZFunctional in vivo characterization of sox10 enhancers in neural crest and melanoma development10.1038/s42003-021-02211-02399-3642https://doaj.org/article/847afc3cf583438186c5a7ab690ba4a32021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02211-0https://doaj.org/toc/2399-3642By performing ATAC-Seq on zebrafish melanoma tumours, Cunningham et al identify putative sox10 enhancers with embryonic activity in zebrafish. They identify a region upstream of sox10, termed peak5, that is needed for full expression of embryonic sox10 and for adult stripe patterning demonstrating an enhancer function for peak5 and provide insights into neural crest development and melanoma initiation.Rebecca L. CunninghamEva T. KramerSophia K. DeGeorgiaPaula M. GodoyAnna P. ZarovShayana SeneviratneVadim GriguraCharles K. KaufmanNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Rebecca L. Cunningham
Eva T. Kramer
Sophia K. DeGeorgia
Paula M. Godoy
Anna P. Zarov
Shayana Seneviratne
Vadim Grigura
Charles K. Kaufman
Functional in vivo characterization of sox10 enhancers in neural crest and melanoma development
description By performing ATAC-Seq on zebrafish melanoma tumours, Cunningham et al identify putative sox10 enhancers with embryonic activity in zebrafish. They identify a region upstream of sox10, termed peak5, that is needed for full expression of embryonic sox10 and for adult stripe patterning demonstrating an enhancer function for peak5 and provide insights into neural crest development and melanoma initiation.
format article
author Rebecca L. Cunningham
Eva T. Kramer
Sophia K. DeGeorgia
Paula M. Godoy
Anna P. Zarov
Shayana Seneviratne
Vadim Grigura
Charles K. Kaufman
author_facet Rebecca L. Cunningham
Eva T. Kramer
Sophia K. DeGeorgia
Paula M. Godoy
Anna P. Zarov
Shayana Seneviratne
Vadim Grigura
Charles K. Kaufman
author_sort Rebecca L. Cunningham
title Functional in vivo characterization of sox10 enhancers in neural crest and melanoma development
title_short Functional in vivo characterization of sox10 enhancers in neural crest and melanoma development
title_full Functional in vivo characterization of sox10 enhancers in neural crest and melanoma development
title_fullStr Functional in vivo characterization of sox10 enhancers in neural crest and melanoma development
title_full_unstemmed Functional in vivo characterization of sox10 enhancers in neural crest and melanoma development
title_sort functional in vivo characterization of sox10 enhancers in neural crest and melanoma development
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/847afc3cf583438186c5a7ab690ba4a3
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AT charleskkaufman functionalinvivocharacterizationofsox10enhancersinneuralcrestandmelanomadevelopment
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