Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy

Spinal and bulbar muscular atrophy is a neuromuscular disease caused by an expanded CAG repeat in the androgen receptor gene. Here the authors show that Src kinase signaling is activated in a mouse model of the disease, and that Src inhibition improves pathology and behavioral symptoms in mice.

Guardado en:

Detalles Bibliográficos
Autores principales:	Madoka Iida, Kentaro Sahashi, Naohide Kondo, Hideaki Nakatsuji, Genki Tohnai, Yutaka Tsutsumi, Seiya Noda, Ayuka Murakami, Kazunari Onodera, Yohei Okada, Masahiro Nakatochi, Yuka Tsukagoshi Okabe, Shinobu Shimizu, Masaaki Mizuno, Hiroaki Adachi, Hideyuki Okano, Gen Sobue, Masahisa Katsuno
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/847b1385413f4d0583de48824f421c0e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:847b1385413f4d0583de48824f421c0e
record_format	dspace
spelling	oai:doaj.org-article:847b1385413f4d0583de48824f421c0e2021-12-02T15:35:29ZSrc inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy10.1038/s41467-019-12282-72041-1723https://doaj.org/article/847b1385413f4d0583de48824f421c0e2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12282-7https://doaj.org/toc/2041-1723Spinal and bulbar muscular atrophy is a neuromuscular disease caused by an expanded CAG repeat in the androgen receptor gene. Here the authors show that Src kinase signaling is activated in a mouse model of the disease, and that Src inhibition improves pathology and behavioral symptoms in mice.Madoka IidaKentaro SahashiNaohide KondoHideaki NakatsujiGenki TohnaiYutaka TsutsumiSeiya NodaAyuka MurakamiKazunari OnoderaYohei OkadaMasahiro NakatochiYuka Tsukagoshi OkabeShinobu ShimizuMasaaki MizunoHiroaki AdachiHideyuki OkanoGen SobueMasahisa KatsunoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Madoka Iida Kentaro Sahashi Naohide Kondo Hideaki Nakatsuji Genki Tohnai Yutaka Tsutsumi Seiya Noda Ayuka Murakami Kazunari Onodera Yohei Okada Masahiro Nakatochi Yuka Tsukagoshi Okabe Shinobu Shimizu Masaaki Mizuno Hiroaki Adachi Hideyuki Okano Gen Sobue Masahisa Katsuno Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy
description	Spinal and bulbar muscular atrophy is a neuromuscular disease caused by an expanded CAG repeat in the androgen receptor gene. Here the authors show that Src kinase signaling is activated in a mouse model of the disease, and that Src inhibition improves pathology and behavioral symptoms in mice.
format	article
author	Madoka Iida Kentaro Sahashi Naohide Kondo Hideaki Nakatsuji Genki Tohnai Yutaka Tsutsumi Seiya Noda Ayuka Murakami Kazunari Onodera Yohei Okada Masahiro Nakatochi Yuka Tsukagoshi Okabe Shinobu Shimizu Masaaki Mizuno Hiroaki Adachi Hideyuki Okano Gen Sobue Masahisa Katsuno
author_facet	Madoka Iida Kentaro Sahashi Naohide Kondo Hideaki Nakatsuji Genki Tohnai Yutaka Tsutsumi Seiya Noda Ayuka Murakami Kazunari Onodera Yohei Okada Masahiro Nakatochi Yuka Tsukagoshi Okabe Shinobu Shimizu Masaaki Mizuno Hiroaki Adachi Hideyuki Okano Gen Sobue Masahisa Katsuno
author_sort	Madoka Iida
title	Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy
title_short	Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy
title_full	Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy
title_fullStr	Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy
title_full_unstemmed	Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy
title_sort	src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/847b1385413f4d0583de48824f421c0e
work_keys_str_mv	AT madokaiida srcinhibitionattenuatespolyglutaminemediatedneuromusculardegenerationinspinalandbulbarmuscularatrophy AT kentarosahashi srcinhibitionattenuatespolyglutaminemediatedneuromusculardegenerationinspinalandbulbarmuscularatrophy AT naohidekondo srcinhibitionattenuatespolyglutaminemediatedneuromusculardegenerationinspinalandbulbarmuscularatrophy AT hideakinakatsuji srcinhibitionattenuatespolyglutaminemediatedneuromusculardegenerationinspinalandbulbarmuscularatrophy AT genkitohnai srcinhibitionattenuatespolyglutaminemediatedneuromusculardegenerationinspinalandbulbarmuscularatrophy AT yutakatsutsumi srcinhibitionattenuatespolyglutaminemediatedneuromusculardegenerationinspinalandbulbarmuscularatrophy AT seiyanoda srcinhibitionattenuatespolyglutaminemediatedneuromusculardegenerationinspinalandbulbarmuscularatrophy AT ayukamurakami srcinhibitionattenuatespolyglutaminemediatedneuromusculardegenerationinspinalandbulbarmuscularatrophy AT kazunarionodera srcinhibitionattenuatespolyglutaminemediatedneuromusculardegenerationinspinalandbulbarmuscularatrophy AT yoheiokada srcinhibitionattenuatespolyglutaminemediatedneuromusculardegenerationinspinalandbulbarmuscularatrophy AT masahironakatochi srcinhibitionattenuatespolyglutaminemediatedneuromusculardegenerationinspinalandbulbarmuscularatrophy AT yukatsukagoshiokabe srcinhibitionattenuatespolyglutaminemediatedneuromusculardegenerationinspinalandbulbarmuscularatrophy AT shinobushimizu srcinhibitionattenuatespolyglutaminemediatedneuromusculardegenerationinspinalandbulbarmuscularatrophy AT masaakimizuno srcinhibitionattenuatespolyglutaminemediatedneuromusculardegenerationinspinalandbulbarmuscularatrophy AT hiroakiadachi srcinhibitionattenuatespolyglutaminemediatedneuromusculardegenerationinspinalandbulbarmuscularatrophy AT hideyukiokano srcinhibitionattenuatespolyglutaminemediatedneuromusculardegenerationinspinalandbulbarmuscularatrophy AT gensobue srcinhibitionattenuatespolyglutaminemediatedneuromusculardegenerationinspinalandbulbarmuscularatrophy AT masahisakatsuno srcinhibitionattenuatespolyglutaminemediatedneuromusculardegenerationinspinalandbulbarmuscularatrophy
_version_	1718386543858548736

Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy

Ejemplares similares