Embryonic–maternal cross-talk via exosomes: potential implications
Islam M Saadeldin,1 Hyun Ju Oh,2 Byeong Chun Lee2,3 1Department of Physiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt; 2Department of Theriogenology and Biotechnology, College of Veterinary Medicine and the Research Institute for Veterinary Science, Seoul National Univers...
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Dove Medical Press
2015
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oai:doaj.org-article:847eb98af4364446808a7f0062feb1f12021-12-02T06:22:00ZEmbryonic–maternal cross-talk via exosomes: potential implications1178-6957https://doaj.org/article/847eb98af4364446808a7f0062feb1f12015-07-01T00:00:00Zhttp://www.dovepress.com/embryonicndashmaternal-cross-talk-via-exosomes-potential-implications-peer-reviewed-article-SCCAAhttps://doaj.org/toc/1178-6957Islam M Saadeldin,1 Hyun Ju Oh,2 Byeong Chun Lee2,3 1Department of Physiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt; 2Department of Theriogenology and Biotechnology, College of Veterinary Medicine and the Research Institute for Veterinary Science, Seoul National University, Seoul, Republic of Korea; 3Institute of Green Bio Science and Technology, Seoul National University, Pyeong Chang, Kangwon do, Republic of KoreaAbstract: A myriad of locally produced factors into the microenvironment of the reproductive tract is regulated, not one-way but rather, through embryonic–maternal cross-talk. In this minireview, we focused on the exosomes, which are cell-derived vesicles of 30–100 nm in diameter, as a communicating language facilitating this dialog. These nanovesicles are secreted from preimplantation embryos, oviduct epithelium, and endometrium as well as from the placenta, and contain proteins, messenger RNA (mRNA), microRNA, and DNA cargoes, and have pleiotropic effects on both embryonic and maternal environments. A better understanding of the molecular mechanisms mediating this cross-talk will lead to the development of new regulating agents, with novel diagnostic, biological, and therapeutic potential for either supporting or hindering the normal reproductive functions. Keywords: embryo, endometrium, placenta, mRNA, miRNASaadeldin IMOh HJLee BCDove Medical PressarticleCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2015, Iss default, Pp 103-107 (2015) |
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Cytology QH573-671 |
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Cytology QH573-671 Saadeldin IM Oh HJ Lee BC Embryonic–maternal cross-talk via exosomes: potential implications |
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Islam M Saadeldin,1 Hyun Ju Oh,2 Byeong Chun Lee2,3 1Department of Physiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt; 2Department of Theriogenology and Biotechnology, College of Veterinary Medicine and the Research Institute for Veterinary Science, Seoul National University, Seoul, Republic of Korea; 3Institute of Green Bio Science and Technology, Seoul National University, Pyeong Chang, Kangwon do, Republic of KoreaAbstract: A myriad of locally produced factors into the microenvironment of the reproductive tract is regulated, not one-way but rather, through embryonic–maternal cross-talk. In this minireview, we focused on the exosomes, which are cell-derived vesicles of 30–100 nm in diameter, as a communicating language facilitating this dialog. These nanovesicles are secreted from preimplantation embryos, oviduct epithelium, and endometrium as well as from the placenta, and contain proteins, messenger RNA (mRNA), microRNA, and DNA cargoes, and have pleiotropic effects on both embryonic and maternal environments. A better understanding of the molecular mechanisms mediating this cross-talk will lead to the development of new regulating agents, with novel diagnostic, biological, and therapeutic potential for either supporting or hindering the normal reproductive functions. Keywords: embryo, endometrium, placenta, mRNA, miRNA |
| format |
article |
| author |
Saadeldin IM Oh HJ Lee BC |
| author_facet |
Saadeldin IM Oh HJ Lee BC |
| author_sort |
Saadeldin IM |
| title |
Embryonic–maternal cross-talk via exosomes: potential implications |
| title_short |
Embryonic–maternal cross-talk via exosomes: potential implications |
| title_full |
Embryonic–maternal cross-talk via exosomes: potential implications |
| title_fullStr |
Embryonic–maternal cross-talk via exosomes: potential implications |
| title_full_unstemmed |
Embryonic–maternal cross-talk via exosomes: potential implications |
| title_sort |
embryonic–maternal cross-talk via exosomes: potential implications |
| publisher |
Dove Medical Press |
| publishDate |
2015 |
| url |
https://doaj.org/article/847eb98af4364446808a7f0062feb1f1 |
| work_keys_str_mv |
AT saadeldinim embryonicndashmaternalcrosstalkviaexosomespotentialimplications AT ohhj embryonicndashmaternalcrosstalkviaexosomespotentialimplications AT leebc embryonicndashmaternalcrosstalkviaexosomespotentialimplications |
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1718399944604254208 |