Investigation of insulin resistance in narcoleptic patients: dependent or independent of body mass index?

Alice Engel1,2, Jana Helfrich1, Nina Manderscheid1, Petra B Musholt3, Thomas Forst3, Andreas Pf&uuml;tzner3, Norbert Dahmen1,21Department of Psychiatry, University of Mainz, Germany; 2Fachklinik Katzenelnbogen, Katzenelnbogen, Germany; 3IKFE, Institute for Clinical Research and Development,...

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Autores principales:	Engel A, Helfrich J, Manderscheid N, Musholt PB, Forst T, Pf&uuml;tzner A, Dahmen N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/8480e57449e14beea1e1698bd3ea4f7b
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spelling	oai:doaj.org-article:8480e57449e14beea1e1698bd3ea4f7b2021-12-02T00:30:08ZInvestigation of insulin resistance in narcoleptic patients: dependent or independent of body mass index?1176-63281178-2021https://doaj.org/article/8480e57449e14beea1e1698bd3ea4f7b2011-06-01T00:00:00Zhttp://www.dovepress.com/investigation-of-insulin-resistance-in-narcoleptic-patients-dependent--a7622https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Alice Engel1,2, Jana Helfrich1, Nina Manderscheid1, Petra B Musholt3, Thomas Forst3, Andreas Pf&uuml;tzner3, Norbert Dahmen1,21Department of Psychiatry, University of Mainz, Germany; 2Fachklinik Katzenelnbogen, Katzenelnbogen, Germany; 3IKFE, Institute for Clinical Research and Development, Mainz, GermanyBackground: Narcolepsy is a severe sleep-wake cycle disorder resulting in most cases from a lack of orexin, the energy balance-regulating hormone. Narcoleptic patients have been reported to suffer from an excess morbidity of Type 2 diabetes, even after correction for their often elevated body mass index.Methods: To explore whether narcolepsy is specifically associated with a propensity to develop insulin resistance, we measured fasting glucose, insulin, and intact proinsulin levels in 43 narcoleptic patients and 47 controls matched for body mass index and age. The proinsulin-to-insulin ratio was calculated. Insulin resistance was determined using the homeostatic model assessment method.Results: Narcoleptic patients did not show elevated insulin resistance parameters.Conclusion: In contrast with earlier reports, we found no evidence that narcolepsy specifically elevates the risk of insulin resistance (and consequently of type 2 diabetes) independently of body mass index.Keywords: fasting glucose, insulin, intact proinsulin, narcolepsy, obesityEngel AHelfrich JManderscheid NMusholt PBForst TPf&uuml;tzner ADahmen NDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2011, Iss Issue 1, Pp 351-356 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Engel A Helfrich J Manderscheid N Musholt PB Forst T Pf&uuml;tzner A Dahmen N Investigation of insulin resistance in narcoleptic patients: dependent or independent of body mass index?
description	Alice Engel1,2, Jana Helfrich1, Nina Manderscheid1, Petra B Musholt3, Thomas Forst3, Andreas Pf&uuml;tzner3, Norbert Dahmen1,21Department of Psychiatry, University of Mainz, Germany; 2Fachklinik Katzenelnbogen, Katzenelnbogen, Germany; 3IKFE, Institute for Clinical Research and Development, Mainz, GermanyBackground: Narcolepsy is a severe sleep-wake cycle disorder resulting in most cases from a lack of orexin, the energy balance-regulating hormone. Narcoleptic patients have been reported to suffer from an excess morbidity of Type 2 diabetes, even after correction for their often elevated body mass index.Methods: To explore whether narcolepsy is specifically associated with a propensity to develop insulin resistance, we measured fasting glucose, insulin, and intact proinsulin levels in 43 narcoleptic patients and 47 controls matched for body mass index and age. The proinsulin-to-insulin ratio was calculated. Insulin resistance was determined using the homeostatic model assessment method.Results: Narcoleptic patients did not show elevated insulin resistance parameters.Conclusion: In contrast with earlier reports, we found no evidence that narcolepsy specifically elevates the risk of insulin resistance (and consequently of type 2 diabetes) independently of body mass index.Keywords: fasting glucose, insulin, intact proinsulin, narcolepsy, obesity
format	article
author	Engel A Helfrich J Manderscheid N Musholt PB Forst T Pf&uuml;tzner A Dahmen N
author_facet	Engel A Helfrich J Manderscheid N Musholt PB Forst T Pf&uuml;tzner A Dahmen N
author_sort	Engel A
title	Investigation of insulin resistance in narcoleptic patients: dependent or independent of body mass index?
title_short	Investigation of insulin resistance in narcoleptic patients: dependent or independent of body mass index?
title_full	Investigation of insulin resistance in narcoleptic patients: dependent or independent of body mass index?
title_fullStr	Investigation of insulin resistance in narcoleptic patients: dependent or independent of body mass index?
title_full_unstemmed	Investigation of insulin resistance in narcoleptic patients: dependent or independent of body mass index?
title_sort	investigation of insulin resistance in narcoleptic patients: dependent or independent of body mass index?
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/8480e57449e14beea1e1698bd3ea4f7b
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Investigation of insulin resistance in narcoleptic patients: dependent or independent of body mass index?

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