The risk of fibromyalgia in patients with iron deficiency anemia: a nationwide population-based cohort study

Abstract Since iron is essential for neurotransmitter synthesis, decreased iron stores might lead to reduced production of biogenic amines which phenomenon was shown in Fibromyalgia (FM) patients. The aims are to investigate the association of iron deficiency anemia (IDA) and FM and to find the effe...

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Autores principales:	Wei-Cheng Yao, Hsuan-Ju Chen, Kam-Hang Leong, Kai-Lan Chang, Yu-Ting Tina Wang, Li-Chin Wu, Po-Ya Tung, Chien-Feng Kuo, Che-Chen Lin, Shin-Yi Tsai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8483eb692df144a3b899f0ee291aebbd
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spelling	oai:doaj.org-article:8483eb692df144a3b899f0ee291aebbd2021-12-02T16:49:46ZThe risk of fibromyalgia in patients with iron deficiency anemia: a nationwide population-based cohort study10.1038/s41598-021-89842-92045-2322https://doaj.org/article/8483eb692df144a3b899f0ee291aebbd2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89842-9https://doaj.org/toc/2045-2322Abstract Since iron is essential for neurotransmitter synthesis, decreased iron stores might lead to reduced production of biogenic amines which phenomenon was shown in Fibromyalgia (FM) patients. The aims are to investigate the association of iron deficiency anemia (IDA) and FM and to find the effects of different interventions. We conducted a study using the Taiwan National Health Insurance Research Database. The IDA cohort consisted of 13,381 patients with newly diagnosed IDA between 2000 and 2008. Each patient with IDA was frequency-matched with one people without IDA, by sex, age and index year. The Cox proportional hazards regression analysis was conducted to estimate the association between IDA and FM risk. The event was the occurrence of FM. The overall incidence density rate of FM in the IDA cohort was higher than in the non-IDA cohort with a multivariable Cox proportional hazards model measured adjusted hazard ratio [HR], 1.19; 95% confidence interval [CI], 1.13–1.25). When using non-IDA group as reference, we compared with different therapies for IDA. The adjusted HRs of FM were 1.38 (95% CI = 1.30–1.47), 1.10 (95% CI = 1.03–1.16), 1.18 (95% CI = 0.98–1.43) and 0.73 (95% CI = 0.58–0.90) for IDA patient without therapy, iron supplement alone, blood transfusion alone and both iron supplement and blood transfusion respectively. Our results suggest IDA is associated with an increased risk of FM. All patients should have iron supplementation both to correct anemia and replenish body stores.Wei-Cheng YaoHsuan-Ju ChenKam-Hang LeongKai-Lan ChangYu-Ting Tina WangLi-Chin WuPo-Ya TungChien-Feng KuoChe-Chen LinShin-Yi TsaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wei-Cheng Yao Hsuan-Ju Chen Kam-Hang Leong Kai-Lan Chang Yu-Ting Tina Wang Li-Chin Wu Po-Ya Tung Chien-Feng Kuo Che-Chen Lin Shin-Yi Tsai The risk of fibromyalgia in patients with iron deficiency anemia: a nationwide population-based cohort study
description	Abstract Since iron is essential for neurotransmitter synthesis, decreased iron stores might lead to reduced production of biogenic amines which phenomenon was shown in Fibromyalgia (FM) patients. The aims are to investigate the association of iron deficiency anemia (IDA) and FM and to find the effects of different interventions. We conducted a study using the Taiwan National Health Insurance Research Database. The IDA cohort consisted of 13,381 patients with newly diagnosed IDA between 2000 and 2008. Each patient with IDA was frequency-matched with one people without IDA, by sex, age and index year. The Cox proportional hazards regression analysis was conducted to estimate the association between IDA and FM risk. The event was the occurrence of FM. The overall incidence density rate of FM in the IDA cohort was higher than in the non-IDA cohort with a multivariable Cox proportional hazards model measured adjusted hazard ratio [HR], 1.19; 95% confidence interval [CI], 1.13–1.25). When using non-IDA group as reference, we compared with different therapies for IDA. The adjusted HRs of FM were 1.38 (95% CI = 1.30–1.47), 1.10 (95% CI = 1.03–1.16), 1.18 (95% CI = 0.98–1.43) and 0.73 (95% CI = 0.58–0.90) for IDA patient without therapy, iron supplement alone, blood transfusion alone and both iron supplement and blood transfusion respectively. Our results suggest IDA is associated with an increased risk of FM. All patients should have iron supplementation both to correct anemia and replenish body stores.
format	article
author	Wei-Cheng Yao Hsuan-Ju Chen Kam-Hang Leong Kai-Lan Chang Yu-Ting Tina Wang Li-Chin Wu Po-Ya Tung Chien-Feng Kuo Che-Chen Lin Shin-Yi Tsai
author_facet	Wei-Cheng Yao Hsuan-Ju Chen Kam-Hang Leong Kai-Lan Chang Yu-Ting Tina Wang Li-Chin Wu Po-Ya Tung Chien-Feng Kuo Che-Chen Lin Shin-Yi Tsai
author_sort	Wei-Cheng Yao
title	The risk of fibromyalgia in patients with iron deficiency anemia: a nationwide population-based cohort study
title_short	The risk of fibromyalgia in patients with iron deficiency anemia: a nationwide population-based cohort study
title_full	The risk of fibromyalgia in patients with iron deficiency anemia: a nationwide population-based cohort study
title_fullStr	The risk of fibromyalgia in patients with iron deficiency anemia: a nationwide population-based cohort study
title_full_unstemmed	The risk of fibromyalgia in patients with iron deficiency anemia: a nationwide population-based cohort study
title_sort	risk of fibromyalgia in patients with iron deficiency anemia: a nationwide population-based cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8483eb692df144a3b899f0ee291aebbd
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The risk of fibromyalgia in patients with iron deficiency anemia: a nationwide population-based cohort study

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